scholarly journals Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

CrystEngComm ◽  
2020 ◽  
Vol 22 (27) ◽  
pp. 4526-4530
Author(s):  
Barbara E. Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Delivery Systems ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
Drug Molecules ◽  
Anti Cancer ◽  
Metal Organic ◽  
Host Metal ◽  
Organic Framework

Low-cost mechanochemistry methods for in situ confinement of “guest” drug molecules into a “host” metal–organic framework to yield nanoscale guest@host drug delivery systems.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Targeted VEGF-triggered release of an anti-cancer drug from aptamer-functionalized metal–organic framework nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 4650-4657 ◽  
Author(s):  
Wei-Hai Chen ◽  
Sohn Yang Sung ◽  
Michael Fadeev ◽  
Alessandro Cecconello ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Cancer Drug ◽  
Triggered Release ◽  
Anti Cancer ◽  
Metal Organic ◽  
Targeted Release ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by the VEGF biomarker, resulting in the targeted release of the drug.

scholarly journals Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

2019 ◽  
Vol 55 (27) ◽  
pp. 3868-3871 ◽  
Author(s):  
Barbara E. Souza ◽  
Svemir Rudić ◽  
Kirill Titov ◽  
Arun S. Babal ◽  
James D. Taylor ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Cancer Drug ◽  
Host Interactions ◽  
Composite Systems ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

Guest–host interactions of mechanochemically synthesized drug@MOF composite systems revealed by inelastic neutron scattering.

In situ growth of metal–organic framework-derived CoTe2 nanoparticles@nitrogen-doped porous carbon polyhedral composites as novel cathodes for rechargeable aluminum-ion batteries

2020 ◽  
Vol 8 (11) ◽  
pp. 5535-5545 ◽  
Author(s):  
Bao Zhang ◽  
Yu Zhang ◽  
Jianling Li ◽  
Jian Liu ◽  
Xiaogeng Huo ◽  
...  
Keyword(s):  
Porous Carbon ◽  
Low Cost ◽  
Metal Organic Framework ◽  
In Situ Growth ◽  
Nitrogen Doped ◽  
Aluminum Ion ◽  
Metal Organic ◽  
High Theoretical Capacity ◽  
Organic Framework

Rechargeable aluminum-ion batteries (AIBs) have attracted widespread attention due to their high theoretical capacity, abundant aluminum resources, high safety and low cost.

A binuclear Co-based metal-organic framework towards efficient oxygen evolution reaction

2021 ◽  
Author(s):  
Ning Liu ◽  
Qiaoqiao Zhang ◽  
Jingqi Guan
Keyword(s):  
Oxygen Evolution ◽  
Oxygen Evolution Reaction ◽  
High Performance ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Research Interest ◽  
Metal Organic ◽  
Organic Framework

Seeking for low-cost and high-performance electrocatalysts for oxygen evolution reaction (OER) has drawn enormous research interest in the last few years. Reported herein is the topotactic construction of a binuclear...

scholarly journals Backbonding contributions to small molecule chemisorption in a metal–organic framework with open copper(i) centers

2021 ◽  
Author(s):  
Gregory M. Su ◽  
Han Wang ◽  
Brandon R. Barnett ◽  
Jeffrey R. Long ◽  
David Prendergast ◽  
...  
Keyword(s):  
Fine Structure ◽  
Small Molecule ◽  
Metal Organic Framework ◽  
X Ray ◽  
Metal Site ◽  
Absorption Fine ◽  
Metal Organic ◽  
X Ray Absorption ◽  
Organic Framework

In situ near edge X-ray absorption fine structure spectroscopy directly probes unoccupied states associated with backbonding interactions between the open metal site in a metal–organic framework and various small molecule guests.

An in situ investigation of the thermal decomposition of metal-organic framework NH2-MIL-125 (Ti)

2021 ◽  
Vol 316 ◽  
pp. 110957
Author(s):  
Mian Zahid Hussain ◽  
Mounib Bahri ◽  
Werner R. Heinz ◽  
Quanli Jia ◽  
Ovidiu Ersen ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Metal Organic Framework ◽  
In Situ Investigation ◽  
Metal Organic ◽  
Organic Framework
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