scholarly journals Concise Chemoenzymatic Synthesis of Fasamycin A

2021 ◽  
Author(s):  
Jian Li ◽  
Hans Renata
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Product ◽  
Enterococcus Faecalis ◽  
Late Stage ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Chemoenzymatic Synthesis ◽  
Vancomycin Resistant Enterococcus ◽  
Chlorine Substituent ◽  
Dieckmann Condensation ◽  
Vancomycin Resistant

<div>We report the development of a chemoenzymatic approach towards fasamycin A, a halogenated naphthacenoid that exhibits activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. The synthesis was accomplished in a convergent manner: two fragments were combined together via Michael−Dieckmann condensation to afford a dimethylnaphthacenone system. Finally, an enzymatic halogenation was employed to introduce the requisite chlorine substituent of the natural product at a late stage.</div><div><br></div>

scholarly journals Concise Chemoenzymatic Synthesis of Fasamycin A

2021 ◽  
Author(s):  
Jian Li ◽  
Hans Renata
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Product ◽  
Enterococcus Faecalis ◽  
Late Stage ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Chemoenzymatic Synthesis ◽  
Vancomycin Resistant Enterococcus ◽  
Chlorine Substituent ◽  
Dieckmann Condensation ◽  
Vancomycin Resistant

<div>We report the development of a chemoenzymatic approach towards fasamycin A, a halogenated naphthacenoid that exhibits activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. The synthesis was accomplished in a convergent manner: two fragments were combined together via Michael−Dieckmann condensation to afford a dimethylnaphthacenone system. Finally, an enzymatic halogenation was employed to introduce the requisite chlorine substituent of the natural product at a late stage.</div><div><br></div>

scholarly journals Red Cabbage Methanol Extract inhibits the growth of Vancomycin-resistant Enterococcus faecalis during Kirby-Bauer Disk Diffusion Susceptibility Test

2015 ◽  
Vol 4 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Priju Varghese
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Enterococcus Faecalis ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methanol Extract ◽  
Micrococcus Luteus ◽  
Vancomycin Resistant Enterococcus ◽  
Zone Of Inhibition ◽  
Red Cabbage ◽  
Vancomycin Resistant

This study was designed to establish whether the red cabbage methanol extract can inhibit the growth of various strains of bacteria which include Micrococcus luteus, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Vancomycin-resistant Enterococcus faecalis (VRE), Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The red cabbage methanol extract discs were resisted by all the strains of bacteria except for VRE and Enterococcus faecalis. While the antibiotic streptomycin was resisted by VRE, the red cabbage methanol extract caused a remarkable zone of inhibition.

An optimized co-formulation minimized quaternary ammonium compounds adsorption onto raw cotton disposable disinfecting wipes and maintained efficacy against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, and Pseudomonas aeruginosa

2017 ◽  
Vol 88 (20) ◽  
pp. 2329-2338 ◽  
Author(s):  
DJ Hinchliffe ◽  
BD Condon ◽  
CA Madison ◽  
M Reynolds ◽  
RJ Hron
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Enterococcus Faecalis ◽  
Quaternary Ammonium ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Ionic Interactions ◽  
Vancomycin Resistant Enterococcus ◽  
Infectious Agents ◽  
Vancomycin Resistant ◽  
Ammonium Compounds

The transmission of infectious agents can occur through secondary routes by contact with contaminated inanimate objects in clinical and food service settings. Effective disinfection of exposed surfaces can aid in reducing secondary transmission of infectious agents. Quaternary ammonium compounds (quats) are biocides widely used as active ingredients in disinfecting solutions and are effective against a wide range of microorganisms, including those with antibiotic resistance. Cellulosic fibers such as cotton are desirable as disposable substrates for the application of disinfecting solutions, since they have good absorbency and cleaning properties and are sustainable and biodegradable. However, cotton fibers deplete quats from solution through strong ionic interactions at the solid–liquid interface, thereby reducing the amount of quat deposited onto a surface for effective disinfection. In this study, we used response surface methodology to model the depletion of the quat, alkyldimethylbenzylammonium chloride (ADBAC), onto cotton wipe substrates in the presence of chemical compounds that interfered or competed with the ionic interactions between the quat and the cotton fiber surface. Preliminary efficacy testing successfully demonstrated that an optimized disinfecting ADBAC co-formulation applied with a raw cotton disposable wipe maintained efficacy against representative gram negative ( Pseudomonas aeruginosa) and gram positive ( Staphylococcus aureus) bacteria compared to a control disinfecting solution containing only ADBAC. Our optimized disinfecting ADBAC co-formulation remained efficacious against Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecalis, demonstrating for the first time that quat adsorption onto cotton substrates can be minimized and efficacy maintained with inexpensive added chemistries.

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