scholarly journals Β-blockers: the lack of taskimplementation or the unwillingness of doctors in the russian federation to optimize the treatment?

2014 ◽  
Vol 11 (1) ◽  
pp. 56-63
Author(s):  
I V Fomin ◽  
D S Polyakov
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Russian Federation ◽  
Representative Sample ◽  
Clinical Manifestations ◽  
The Russian Federation ◽  
Β Blockers ◽  
Artery Disease ◽  
Almost All

The purpose of the study. The achievedheart rate of 50-60 beats per minute in patients after acute myocardial infarction, and up to50-70 beats per minute for patients with stable angina is considered effective. Assuming that in Russia low doses of β-blockers are often used, thequestion was raised: «How common tachycardia can bein patients with coronary heart disease (CHD) and chronic heart failure (CHF), and whether there are strategic approaches to achieving the targets in heart rate in these patients in real clinical practice and are β-blockers often used in patients for whom this group of drugs is the basic one?»Materials and Methods. Work carried out in the framework of the Russian epidemiological study of a representative sample of the European partof the Russian Federation. All patients with CHF and coronary artery disease were divided into two subgroups: heart rate reducers not receiving medicines and receiving at least one heart rate reducing drug (a β-blocker, calcium channel 1 and 3rd type (AK) blockers, glycosides).Results and discussion. In a representative sample of the program in healthy individuals (without clinical manifestations of coronary arterydisease) tachycardia was diagnosed in 7,1% of cases. Almost all respondents without CHD (87,3%) had normal heart rate from 61 to 80 beats per minute. Number of respondents without CHD with heart rate of 70 to 79 bpm. per min. (54,1%) turned out to be significantly less than that of patients with rhythm in any form of coronary artery disease (p

scholarly journals Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia

2011 ◽  
Vol 65 (3-4) ◽  
pp. 94-101
Author(s):  
Inga Balode ◽  
Sanda Jēgere ◽  
Iveta Mintāle ◽  
Inga Narbute ◽  
Gustavs Latkovskis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Angiotensin Receptor Blockers ◽  
Stable Coronary Artery Disease ◽  
Pulse Palpation ◽  
Co Morbidity ◽  
Β Blockers ◽  
Artery Disease

Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia The aim of the study was to characterise coronary artery disease (CAD) outpatients in Latvia by risk factors (RF) including heart rate (HR), physical examination data, clinical data and treatment. Twelve practitioners had each examined and questioned 6 to 12 patients with established CAD (n = 120). The most frequent cardiovascular (CV) RF and co-morbidity were dyslipidemia (94.2%) and hypertension (78.3%), respectively. Prevalence of increased resting HR (≥70 bpm) was 35.9% and 33.6%, when measured by pulse palpation and electrocardiography, respectively. Regarding other RFs, prevalence of treated but insufficiently controlled blood pressure 140/90 mmHg, total cholesterol 1 > 5 mmol/l and triglycerides > 1.7 mmol/l was 25.8%, 30.1% and 33.3%, respectively. Aspirin, statins and angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers were used in 96.7%, 94.2% and 85.0% of cases, respectively. Beta blockers were used in 81.7% of cases. Average daily doses of most frequently used β blockers (metoprolol and bisoprolol) were 32% and 53% from target doses, respectively. In three cases β blockers were combined with ivabradin. Our results suggest that practitioners follow guidelines and consider CV prevention by treating CAD patients. Our data identified, however, unused potential for better control of increased HR by higher doses and combinations of HR-reducing agents.

scholarly journals Differential Effect of β-Blockers for Heart Rate Control in Coronary Artery Disease

2011 ◽  
Vol 34 (12) ◽  
pp. 748-754 ◽  
Author(s):  
Alberto Cordero ◽  
Vicente Bertomeu-González ◽  
Pilar Mazón ◽  
José Moreno-Arribas ◽  
Lorenzo Fácila ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Rate Control ◽  
Differential Effect ◽  
Heart Rate Control ◽  
Β Blockers ◽  
Artery Disease

scholarly journals The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension different degrees

2022 ◽  
Vol 28 (5) ◽  
pp. 24-38
Author(s):  
M. І. Lutay ◽  
І. P. Golikova
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Fixed Combination ◽  
Clinical Manifestations ◽  
Current Therapy ◽  
Artery Disease ◽  
Adherence To Therapy ◽  
Antianginal Efficacy

The aim – to evaluate the hypotensive and antianginal efficacy of a fixed double combination (bisoprolol, perindopril) in patients with coronary artery disease (CAD) and concomitant hypertension.Materials and methods. The study involved 170 cardiologists from various regions of Ukraine. Each researcher selected 15 consecutive outpatients with coronary heart disease who came for a regular visit. Inclusion criteria: age over 18 years old, blood pressure (BP) above 140/90 mm Hg, heart rate (HR) above 60 bpm, bisoprolol as part of antihypertensive therapy in the last ≥ 3 months. The study included two visits. At each visit, the patient’s objective status was assessed; an individual questionnaire with office systolic and diastolic blood pressure, heart rate, ECG data, clinical manifestations of CAD, risk factors, lifestyle features, concomitant diseases, current therapy was filled out. Medication adherence was also evaluated, the therapy was corrected if necessary and the presence of side effects and adverse events was registered. We analyzed the levels of BP and HR at the beginning and at the end of the study, the percentage of achievement of the recommended levels of these indicators, the antianginal efficacy of treatment and adherence to therapy in patients with CAD and different degrees of hypertension after 4 weeks of treatment.Results and discussion. 2785 patient questionnaires were provided by doctors, 1747 patients were included in substudy. The mean age of the patients was 60.9±10.2 years old, men – 57.1 %, women – 42.9 %. The diagnosis of coronary artery disease was based on: chest pain – 554 (31.7 %), a history of documented myocardial infarction – 935 (53.5 %), coronary ventriculography – 536 (30.7 %), revascularization (CABG/stenting) – 344 (19.8 %) patients. The use of a fixed combination of previously taken drugs (perindopril, bisoprolol) for 4 weeks allows to reduce heart rate and blood pressure effectively (HR ≤ 70 bpm reached 84.9 % of patients, BP ≤ 140/90 mm Hg – 86.9 %), to reduce the number of angina attacks (from 4.48, 4.5 and 4.7 per week at the beginning of the study to 2.4; 2.9 and 2.3 per week in patients with 1, 2 and 3 degrees of hypertension, respectively) and the need for nitroglycerin from from 4.5; 4.9 and 5.9 tab per week up to 2.4; 2.9 and 2.3 tab per week. The most significant absolute decrease of BP and HR was in patients with a more severe degree of hypertension (decrease systolic BP was – 40.8 mm Hg, diastolic BP – 21.4 mm Hg, HR – 21.8 bpm).Conclusions. The study demonstrated that the use of the fixed combination of bisoprolol and perindopril in patients with coronary artery disease and concomitant hypertension (different degrees) helps to improve treatment efficacy, to achieve recommended levels of blood pressure and heart rate, also has a significant antianginal effect (reliable decrease of the number of angina attacks and the need to take nitroglycerin) and increases adherence to therapy.

scholarly journals 2020 Clinical practice guidelines for Stable coronary artery disease

2020 ◽  
Vol 25 (11) ◽  
pp. 4076
Author(s):  
. Russian Society of Cardiology (RSC)
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Practice ◽  
Coronary Artery ◽  
Russian Federation ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Stable Coronary Artery Disease ◽  
Ministry Of Health ◽  
The Russian Federation ◽  
Artery Disease

Approved by the Research and Practical Council of the Ministry of Health of the Russian Federation.

scholarly journals Heart rate and use of β-blockers in Mexican stable outpatients with coronary artery disease

2015 ◽  
Vol 85 (4) ◽  
pp. 270-277
Author(s):  
Marco Antonio Alcocer-Gamba ◽  
Carlos Martínez-Sánchez ◽  
Juan Verdejo-Paris ◽  
Roberto Ferrari ◽  
Kim Fox ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Β Blockers ◽  
Artery Disease

scholarly journals MORTALITY FROM CIRCULATORY SYSTEM DISEASES IN THE KEMEROVO REGION AND THE RUSSIAN FEDERATION IN 2000–2016

2019 ◽  
Vol 8 (2) ◽  
pp. 6-11
Author(s):  
S. A. Makarov ◽  
S. A. Maksimov ◽  
E. B. Shapovalova ◽  
D. S. Stryapchev ◽  
G. V. Artamonova
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Russian Federation ◽  
Circulatory System ◽  
Mortality Rates ◽  
Cerebrovascular Diseases ◽  
Circulatory System Diseases ◽  
The Russian Federation ◽  
Artery Disease ◽  
Regional Mortality

Aim. To estimate the trends in mortality from circulatory system diseases, including coronary artery disease and cerebrovascular diseases, in the Kemerovo region in the period from 2000 to 2016 and compare it with the national trends.Methods. Data on national mortality rates, including those among adults of working age (men 16–59 years, women 16–54 years) from circulatory system diseases, coronary artery disease and cerebrovascular diseases in the period from 2000 to 2016 were obtained through the national statistical reports. A linear trend in the regional mortality rate to the national one has been reported.Results. Mortality rate from circulatory system diseases in the period from 2000 to 2016 tends to a decrease in the Kemerovo region and the Russian Federation. The comparative analysis of mortality rates in the Kemerovo region and the Russian Federation reported lower regional mortality rates in the general population. Despite lower mortality rates from coronary artery disease in the general population and working population, there are higher mortality rates from cerebrovascular diseases. Conclusion. The trend in mortality from circulatory system diseases in the Kemerovo region is comparable to that in the Russian Federation. Specific regional features related to the interaction of various factors, including regional healthcare system, have been determined. The trends in mortality from coronary artery disease and cerebrovascular diseases in the period from 2000 to 2016 have been presented.

scholarly journals Medicamentous therapy of stable coronary artery disease sensu the guidelines on myocardial revascularization

2020 ◽  
Author(s):  
Olga Posnenkova ◽  
Ekaterina Genkal ◽  
Yulia Popova ◽  
Anton Kiselev ◽  
Vladimir Gridnev
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Russian Federation ◽  
Stable Coronary Artery Disease ◽  
Myocardial Revascularization ◽  
The Russian Federation ◽  
Artery Disease ◽  
Stable Cad ◽  
Multicenter Registry

Objective: based on the Russian Federation multicenter registry data, to assess the comprehensiveness of medicamentous therapy in patients with stable coronary artery disease (CAD) from the perspective of 2018 European Society of Cardiology (ESC-2018) recommendations for myocardial revascularization and 2017 American Appropriate Use Criteria (AUC-2017) for the expediency of revascularization. Materials and methods. Anamnestic data of 1531 patients with stable CAD (average age: 61.7 ± 9.8 years; 76% men) were studied. The data source was the Russian Federation multicenter registry of patients with arterial hypertension, CAD, and chronic heart failure. We identified the prescription of optimal medical therapy (OMT) sensu ESC-2018, maximal anti-ischemic therapy (MAT) sensu AUC-2017, and compliance of drug therapy with ESC-2018 and AUC-2017 simultaneously. OMT included at least one anti-ischemic medication + antiplatelet agent + statin + short-acting nitrate + blocker of the renin-angiotensin system in the presence of hypertension, diabetes mellitus, or heart failure. MAT included at least two anti-ischemic pharmaceutical drugs. Compliance with these criteria was determined in the groups of patients who underwent, or did not undergo, myocardial revascularization, as well as among those, for whom invasive treatment was indicated as the first priority, as the second priority, or was not indicated at all, according to ESC-2018 and AUC-2017. Results. Among patients who received solely medicamentous therapy (n=924), OMT was prescribed in 18%, while in the revascularization group (n= 07), in 9% of cases (p <0.001). MAT was also prescribed more often in the conservative therapy group (34%) than in the revascularization group (24%): p = 0.001. OMT sensu ESC-2018 and AUC-2017 in the groups with, or without, intervention was prescribed in 3% vs. 7% of cases, respectively (p <0.001). Conclusion. According to the Russian Federation multicenter registry, medicamentous therapy of stable CAD complies with the provisions of European and American clinical guidelines for myocardial revascularization in a small proportion of patients, regardless of the chosen treatment tactics.

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