The effect of PRK on corneal epithelium thickness and pachmetry in treatment of myopia.

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Furkaan Majied Hamied ◽  
Deyaa Neama Kadhim ◽  
Sohaib A Mahmood
Keyword(s):  
Refractive Error ◽  
Anterior Segment ◽  
Thickness Change ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Refractive Outcomes ◽  
Epithelium Thickness ◽  
Profile Changes ◽  
Corneal Epithelial Thickness ◽  
Myopic Astigmatism

In order to facilitate the corneal stromal ablation in photorefractive keratectomy the epithelium is removed so corneal repair associated with changes in epithelium and stroma. To study the corneal epithelial thickness and pachymetry profile changes after photorefractive keratec­tomy (PRK) for myopia. Retrospective analysis of the postoperative corneal epithelial thickness and pachymetry profile changes in 22 eyes of 12 patients treated with PRK for myopia or myopic astigmatism. Corneal and epithelial thickness maps within the central 6 mm were obtained by anterior segment spectral-domain optical coherence tomography (SD-OCT) preop­eratively and at 3 months postoperatively. Correlations between pachymetry,epithelial thickness changes and the amount of correction,were analyzed.Compared to preoperative values,the central 2 mm and the paracentral 2 to 5 mm zone epithelium was 1 ± 2.85 and 1 ± 3.11 μm thicker,respec­tively,at 3 months postoperatively (P <.05). The spheri­cal equivalent (SE) changed from-2.80 ± 2.028 diop­ters (D) preoperatively to -0.40 ± 0.42 D at 3 months postoperatively. Females show greater postoperative epithelial thickening, 2.6 ± 3.77 μm,than males,0.34 ± 1.98 μm. There was a trend toward greater epithelial thickening with a larger amount of programmed SE correction, and thinner preoperative epithelium. No correlation between epithelial thickness change and postoperative change in refraction was detected.Negative correlation between between age, refractive error,with the pre and post-operative pachymetry. In general female pachymetry reading is higher than it in male.The corneal epithelial thickness in­creased after PRK up to 3 months postoperatively. It was affected by the amount of myopia treated, gender, and preoperative epithelial thickness. The refractive outcomes did not affected by the postoperative epithelial thickening. Negative correlation between between age, refractive error, with the pre and post-operative pachymetry. In general female pachymetry reading is higher than it in male.

Graft epithelial mapping following penetrating keratoplasty using anterior segment optical coherence tomography

2021 ◽  
Vol 2 (1) ◽  
pp. 20-24
Author(s):  
Shaimaa A Arfeen ◽  
◽  
Noha M Khalil ◽  
Ghada A Nassar ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Graft Rejection ◽  
Allograft Rejection ◽  
Penetrating Keratoplasty ◽  
Thickness Distribution ◽  
Anterior Segment ◽  
Study Group ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

AIM: To evaluate the changes in corneal epithelial thickness in corneal grafts following penetrating keratoplasty (PK) using anterior segment optical coherence tomography (AS-OCT), and to determine the role of epithelial thickness mapping in the early detection of graft rejection. METHODS: This prospective comparative observational study included 20 patients (20 eyes) who underwent PK as study group and 16 patients (16 eyes) as control group. Corneal epithelial thickness mapping using AS-OCT was performed at 2wk, 1 and 3mo postoperatively. The parameters of epithelial thickness and distribution at the 3mo were compared to 16 patients (16 eyes) with allograft rejection following PK. RESULTS: There was significant decline in the superior, inferior, maximum, and minimum epithelial thickness values of the study group at 1mo compared to 2wk (P=0.0004, 0.0001, 0.0001, 0.04 respectively) with no significant differences at 3mo compared to 1mo (P=0.4, 0.1, 0.8) respectively. Percentage of reduction in epithelial thickness was significantly higher than that of stromal thickness at 1mo compared to 2wk (P=0.04). The epithelial thickness maps showed a similar pattern of epithelial thickness distribution in the study group and in the rejection group showing considerable corneal edema. However, the allograft rejection group showed irregular pattern of epithelial thickness distribution in patients showing relatively higher central corneal thickness (CCT) as measured by pachymetry map. CONCLUSION: Quantitative assessment of graft epithelial remodeling following PK shows early changes that contribute to significant corneal graft thickness changes. Changes in corneal epithelial thickness and pattern of distribution could be used as an indicator for corneal graft rejection.

Effects of topical antiglaucomatous medications on central corneal epithelial thickness by anterior segment optical coherence tomography

2020 ◽  
Vol 30 (6) ◽  
pp. 1519-1524
Author(s):  
Emine Doğan ◽  
Burçin Köklü Çakır ◽  
Nilgün Özkan Aksoy ◽  
Erkan Celik ◽  
Ünal Erkorkmaz
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Tear Film ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Duration Of Therapy ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Purpose: To evaluate the effect of topical antiglaucomatous medications on central corneal epithelial thickness measured by anterior segment optical coherence tomography. Materials and methods: A total of 153 eyes of 153 patients using topical antiglaucomatous medications and 110 eyes of 110 control subjects were enrolled. Glaucoma type, duration of therapy, the number of drugs, and drops/day were noted in the patient group. Patients and control subjects underwent ocular examinations including Schirmer test, slit lamp examination for tear film break-up time, and anterior segment optical coherence tomography for central corneal thickness and central corneal epithelial thickness. Central corneal epithelial thickness and other data were evaluated separately with regard to glaucoma type, duration of therapy, the number of drops, and drugs in the patient group. Results: The mean ages of the patients and controls were 60.1 ± 10.8 and 58.7 ± 11.2 years, respectively. The groups were similar with regard to mean age and gender (p = 0.058, p = 0.734, respectively). The median (interquartile range) central corneal thickness was 536 (54) µm in patients and 552 (53) µm in controls (p = 0.011). The median (interquartile range) central corneal epithelial thickness of patients and controls were 56 (4) µm and 60 (8) µm, respectively (p < 0.001). The median (interquartile range) tear film break-up time and Schirmer were 12 (6) s and 10 (8) mm in patients and 16 (2) s and 18 (4) mm in controls, respectively (p < 0.001, p < 0.001). In patient group, there was no significant difference in the median central corneal thickness, central corneal epithelial thickness, and tear film break-up time in terms of glaucoma type, duration of therapy, the number of drugs, and the number of daily drops. Only the median Schirmer test was found to be statistically lower in terms of number of daily eye drops (p = 0.039). Conclusion: Using topical antiglaucomatous medications seems to affect the central corneal epithelial thickness in glaucoma patients. Central corneal epithelial thickness was thinner in glaucoma patients than controls. Anterior segment optical coherence tomography might be helpful to evaluate the effect of antiglaucomatous medications on central corneal epithelial thickness during treatment.

scholarly journals Assessment of Corneal Epithelial Thickness in Chronic Contact Lens Users Using Anterior Segment Optical Coherence Tomography

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A A M E A Rezk ◽  
A Assaf ◽  
M Gamil ◽  
T Badran
Keyword(s):  
Contact Lens ◽  
Corneal Epithelium ◽  
Refractive Surgery ◽  
Anterior Segment ◽  
Control Group ◽  
Soft Contact ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Soft Contact Lens ◽  
Corneal Epithelial Thickness

Abstract Introduction The corneal epithelium is stratified epithelium that is continuously renewed and provides the frontline of defence against invading ocular pathogens and a smooth refractive surface essential for vision. In the absence of a contact lens, pre-existing ocular trauma or disease, the epithelium maintains an inaccessible defence against attacks from pathogenic microorganisms, affording a high level of resistance against microbial invasion. Aim The aim of this study is to determine the effect of chronic use of contact lens on corneal epithelium thickness using anterior segment optical coherence topography as a non- invasive diagnostic accurate measure. Patients and Methods 30 eyes of control subjects who don’t wear contact lens along their life aged between 15-45 years ,where compared with similar age group of 30 eyes of chronic contact lens users; who wear contact lens every day not less than 8 hours per day for along time interval between 6 months up to 5 years. Results The average corneal epithelial thickness in the central, paracentral and midperipheral zones was 47.767 ± 5.550 µm, 46.267 ± 5.644 µm, 44.300 ± 4.858 µm, respectively, in chronic soft contact lens users; and 49.800 ± 3.316 µm, 49.200 ± 3.367 µm, 45.733 ± 2.333 µm ,in control group who had never worn contact lens. There were insignificant thinning of corneal epithelium of soft contact group compared to control group regarding the average corneal epithelial thickness in those 3 zones. In all the 8 sectors of corneal epithelium of paracentral zone and midperipheral zones there is insignificant thinning between the two groups except for the inferior temporal sector in the paracentral zone and mid peripheral zone, which shows significant thinning in soft contact lens group compared to control group. The corneal epithelial thickness in the inferior temporal sector of paracentral and mid peripheral zones was 46.333 ± 5.677 µm, 44.933 ± 4.813 µm, respectively, in chronic soft contact lens users compared to 48.767 ± 3.266 µm, 46.900 ± 2.510 µm in control group (p = 0.046, p = 0.052, respectively). Conclusion AS-OCT helps us to evaluate the corneal epithelium of contact lens users, which could be very useful in corneal refractive surgeries in patients depending on contact lens in their lives as a comfortable refractive aid, It is necessary to do AS-OCT hand on hand with pentacam in patients underwhelming refractive surgery to give a proper assessment to their corneal epithelium before determining which type of refractive surgery suits them.

scholarly journals Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mario Nubile ◽  
Niccolò Salgari ◽  
Jodhbir S. Mehta ◽  
Roberta Calienno ◽  
Emanuele Erroi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Observational Study ◽  
Femtosecond Laser ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Corneal Epithelial ◽  
Cadaveric Donor ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

AbstractThe purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.

scholarly journals Corneal Epithelial Remodeling after LASIK Measured by Fourier-Domain Optical Coherence Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Maolong Tang ◽  
Yan Li ◽  
David Huang
Keyword(s):  
Mathematical Model ◽  
Fourier Domain ◽  
Spherical Equivalent ◽  
Thickness Change ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Before And After ◽  
Epithelial Remodeling ◽  
Corneal Epithelial Thickness ◽  
Fourier Domain Oct

Purpose. To quantify corneal epithelial thickness changes after myopic LASIK by OCT.Methods.Epithelial thickness before and after myopic LASIK were measured by a Fourier-domain OCT system. Average central (within 1 mm diameter) and paracentral epithelial thickness (5~6 mm diameter) before and after LASIK were compared. Correlation between central epithelial thickness change and laser spherical equivalent setting was evaluated. An epithelial smoothing constant was estimated based on a mathematical model published previously.Results.Nineteen eyes from 11 subjects were included in the study. Eyes had myopic LASIK ranging from −1.69 D to −6.75 D spherical equivalent. The average central epithelial thickness was 52.6 ± 4.1 μm before LASIK and 56.2 ± 4.3 μm 3 months after LASIK (p=0.002). The average paracentral epithelial thickness was 51.6 ± 6.6 μm before LASIK and 54.8 ± 4.3 μm 3 months after LASIK (p=0.007). The change in average central epithelial thickness was correlated with laser spherical equivalent (R2= 0.40,p=0.028). The epithelial smoothing constant was estimated to be 0.46 mm.Conclusions. Corneal epithelial thickens centrally and paracentrally after myopic LASIK. The extent of epithelial remodeling correlated with the amount of LASIK correction and could be predicted by a mathematical model.

scholarly journals Evaluation of Central Corneal Epithelial Thickness With Anterior Segment OCT in Patients With Type 2 Diabetes Mellitus

2022 ◽  
Author(s):  
elif yusufoglu ◽  
sabiha güngör kobat ◽  
sinem keser
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hba1c Level ◽  
Anterior Segment ◽  
Diabetic Patients ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Abstract Aim: The aim of this study was to evaluate the central corneal thickness (CCT) and central corneal epithelial thickness (CCET) in patients with Type 2 diabetes mellitus (DM), and the effect of the duration of diabetes, the degree of diabetic retinopathy (DR), and HbA1c level. Method: CCT and CCET values ​​of 72 patients diagnosed with type 2 DM and 72 healthy individuals were measured by anterior segment optical coherence tomography (AS-OCT). The eye tear function was evaluated with the Tear Break-up Time test (TBUT) and the Schirmer test. From the results of fundus examination, the diabetic patients were grouped as those without DR, with non-proliferative DR, and with proliferative DR. The disease duration and the HbA1c levels were recorded. Results: In the diabetic patients, the mean CCT was determined to be thicker (p=0.025), the CCET was thinner (p=0.003), and the TBUT and Schirmer values were lower (p<0.001, p<0.001, respectively). The duration of diabetes and the HbA1c level were not found to have any statistically significant effect on these parameters (p>0.05). The presence of retinopathy had no significant effect on CCT, TBUT and Schirmer values. The CCET was determined to be thinner in patients with retinopathy (p<0.001). Conclusion: As the corneal epithelial thickness is reduced in patients with advanced diabetic retinopathy, corneal epithelial pathologies can be seen more often. Therefore, early and effective treatment can be started taking into consideration the complications which may develop associated with the corneal epithelium following surgical procedures, especially those applied to the cornea.

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