scholarly journals MODIFICATION OF CALCIUM PHOSPHATE FOAM CERAMICS WITH BIOAPATITE IN SBF SOLUTION

2021 ◽  
pp. 870-880
Author(s):  
Валентина Константиновна Крутько ◽  
Любовь Юрьевна Маслова ◽  
Ольга Николаевна Мусская ◽  
Татьяна Викторовна Сафронова ◽  
Анатолий Иосифович Кулак
Keyword(s):  
Calcium Phosphate ◽  
Polyurethane Foam ◽  
Tricalcium Phosphate ◽  
Calcium Pyrophosphate ◽  
Static Strength ◽  
Sbf Solution

Получена многофазная кальцийфосфатная пенокерамика, представленная Д -трикальцийфосфатом (65 %) и Д -пирофосфатом кальция (25 %), включающая гидроксиапатит ( 5 %) и а -трикальцийфосфат ( 5 %), пористостью 60 - 64 % со сквозной архитектурой пенополиуретана. Нанесение слоя гидроксиапатита приводило к увеличению содержания гидроксиапатита до 25 %, а -трикальцийфосфата до 40 %, и повышению статической прочности до 0,03 МПа при снижении пористости до 49 %. Нанесение второго слоя гидроксиапатита способствовало повышению содержания гидроксиапатита до 40 %, статическая прочность достигала 0,05 МПа при пористости 40%. Формирование биоапатита в виде слоя «пеносфер» размером от 2 до 10 мкм происходило в процессе модифицирования всех видов пенокерамики в растворе SBF в течение 21 - 28 суток. Модифицированная кальцийфосфатная пенокерамика, обогащенная а -трикальцийфосфатом и гидроксиапатитом, характеризовалась максимальной статической прочностью 0,08 МПа при пористости 38%. The multiphase calcium phosphate foam ceramics, represented by р -tricalcium phosphate (65 %) and р -calcium pyrophosphate (25 %), including hydroxyapatite (5 %) and а -tricalcium phosphate (5%), with 60 - 64% porosity and a through architecture of polyurethane foam was obtained. The application of a layer of hydroxyapatite led to an increase in the content of hydroxyapatite to 25 %, а -tricalcium phosphate to 40%, and an increase in static strength to 0,03 MPa with a decrease in porosity to 49%. The application of the second layer of hydroxyapatite promoted an increase in the content of hydroxyapatite to 40%, the static strength reached 0,05 MPa at a porosity 40 %. The bioapatite formation in the shape of «foam spheres» with a size from 2 to 10 pm occurred in the process of modifying all types of foam ceramics in a SBF solution during 21 - 28 days. The modified calcium phosphate foam ceramics enriched with а -tricalcium phosphate and hydroxyapatite, was characterized by the maximum static strength 0,08 MPa at a porosity 38 %.

Bimodal Porous Bi-Phasic Calcium Phosphate Ceramics and Its Dissolution in SBF Solution

2007 ◽  
Vol 330-332 ◽  
pp. 91-94 ◽  
Author(s):  
Y. Zhang ◽  
Yoshiyuki Yokogawa ◽  
Tetsuya Kameyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Reaction Rate ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramics ◽  
Fine Powders ◽  
Beta Tricalcium Phosphate ◽  
Sbf Solution ◽  
New Phase

Biphasic calcium phosphate (BCP) ceramics, a mixture of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP), of varying HAp/β-TCP ratios were prepared from fine powders. Porous BCP ceramic materials with HAp/β-TCP weight rations of 20/80, 40/60, and 80/20 were prepared. In this study, the bioactivity is reduced at a larger HAp content rate, which is likely related to the high driving pore for the formation of a new phase, and the reaction rate was proportional to the β-TCP. The porous BCP ceramics having a bigger porosity rate can easily under up dissolution. The powder having a larger β-TCP content rate can easily generate a new phase. The dissolution results confirmed that the biodegradation of calcium phosphate ceramics could be controlled by simply adjusting the amount of HAp or β-TCP in the ceramics and porosity rate.

Evaluation of α-Tricalcium Phosphate Cement Obtained at Different Temperatures

2012 ◽  
Vol 727-728 ◽  
pp. 1187-1192 ◽  
Author(s):  
Rafaela Silveira Vieira ◽  
Wilbur Trajano Guerin Coelho ◽  
Mônica Beatriz Thürmer ◽  
Juliana Machado Fernandes ◽  
Luis Alberto Santos
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Calcium Pyrophosphate ◽  
In Vitro Test ◽  
Calcium Phosphate Cements ◽  
Similar Chemical ◽  
Different Temperatures ◽  
Vitro Test

The calcium phosphate cements (CPCs) based on α-tricalcium phosphate (α-TCP) are highly attractive for use in medicine and odontology, since they have similar chemical and phase composition of mineral phase of bones (calcium deficient hydroxyapatite (CDHA)). However, one of the biggest difficulties for use of this type of cement is its low mechanical strength due to the presence of undesirable phases, such as β-tricalcium phosphate. The route for obtaining α-TCP is at high temperature by solid state reaction, mixing calcium carbonate and calcium pyrophosphate. The aim of this work was to obtain calcium phosphate cements with improved strength, by studying the obtaining of α-TCP at temperatures of 1300, 1400 and 1500°C. The samples were analyzed by crystalline phases, pH, setting time, particle size, in vitro test (Simulated Body Fluid), porosity, density and compressive strength. The results show that the synthesis temperatures influence strongly the phases of powders obtained and the mechanical properties of cement, being unnecessary quenching for obtaining pure α-TCP.

scholarly journals The preparation and application of calcium phosphate biomedical composites in filling of weight-bearing bone defects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lijia Cheng ◽  
Tianchang Lin ◽  
Ahmad Taha Khalaf ◽  
Yamei Zhang ◽  
Hongyan He ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Weight Bearing ◽  
Bone Defects ◽  
Type I ◽  
Artificial Bone ◽  
Thermosensitive Hydrogel ◽  
Bone Repairing ◽  
Histological Staining

AbstractNowadays, artificial bone materials have been widely applied in the filling of non-weight bearing bone defects, but scarcely ever in weight-bearing bone defects. This study aims to develop an artificial bone with excellent mechanical properties and good osteogenic capability. Firstly, the collagen-thermosensitive hydrogel-calcium phosphate (CTC) composites were prepared as follows: dissolving thermosensitive hydrogel at 4 °C, then mixing with type I collagen as well as tricalcium phosphate (CaP) powder, and moulding the composites at 37 °C. Next, the CTC composites were subjected to evaluate for their chemical composition, micro morphology, pore size, Shore durometer, porosity and water absorption ability. Following this, the CTC composites were implanted into the muscle of mice while the 70% hydroxyapatite/30% β-tricalcium phosphate (HA/TCP) biomaterials were set as the control group; 8 weeks later, the osteoinductive abilities of biomaterials were detected by histological staining. Finally, the CTC and HA/TCP biomaterials were used to fill the large segments of tibia defects in mice. The bone repairing and load-bearing abilities of materials were evaluated by histological staining, X-ray and micro-CT at week 8. Both the CTC and HA/TCP biomaterials could induce ectopic bone formation in mice; however, the CTC composites tended to produce larger areas of bone and bone marrow tissues than HA/TCP. Simultaneously, bone-repairing experiments showed that HA/TCP biomaterials were easily crushed or pushed out by new bone growth as the material has a poor hardness. In comparison, the CTC composites could be replaced gradually by newly formed bone and repair larger segments of bone defects. The CTC composites trialled in this study have better mechanical properties, osteoinductivity and weight-bearing capacity than HA/TCP. The CTC composites provide an experimental foundation for the synthesis of artificial bone and a new option for orthopedic patients.

Synthesis of Alpha-Tricalcium Phosphate by Wet Reaction and Evaluation of Mechanical Properties

2012 ◽  
Vol 727-728 ◽  
pp. 1164-1169 ◽  
Author(s):  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Juliana Machado Fernandes ◽  
Wilbur Trajano Guerin Coelho ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Nitrate ◽  
Chemical Precipitation ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calcium Phosphate Cements

Calcium phosphate cements have bioactivity and osteoconductivity and can be molded and replace portions of bone tissue. The aim of this work was to study the obtainment of α-tricalcium phosphate, the main phase of calcium phosphate cement, by wet reaction from calcium nitrate and phosphoric acid. There are no reports about α-tricalcium phosphate obtained by this method. Two routes of chemical precipitation were evaluated and the use of two calcinations temperatures to obtain the phase of cement. The influence of calcination temperature on the mechanical properties of cement was evaluated. Cement samples were characterized by particle size analysis, X-ray diffraction, mechanical strength and scanning electron microscopy. The results demonstrate the strong influence of synthesis route on the crystalline phases of cement and the influence of concentration of reactants on the product of the reaction, as well as, on the mechanical properties of cement.

Processing and in vivo evaluation of multiphasic calcium phosphate cements with dual tricalcium phosphate phases

2012 ◽  
Vol 8 (9) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Matilde Bongio ◽  
Marc Bohner ◽  
Vincent Cuijpers ◽  
Louis A.J.A. Winnubst ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Cements

scholarly journals Production and Characterization of a 316L Stainless Steel/β-TCP Biocomposite Using the Functionally Graded Materials (FGMs) Technique for Dental and Orthopedic Applications

Metals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1923
Author(s):  
Bruna Horta Bastos Kuffner ◽  
Patricia Capellato ◽  
Larissa Mayra Silva Ribeiro ◽  
Daniela Sachs ◽  
Gilbert Silva
Keyword(s):  
Mechanical Properties ◽  
Stainless Steel ◽  
Calcium Phosphate ◽  
Functionally Graded Materials ◽  
Tricalcium Phosphate ◽  
316L Stainless Steel ◽  
Functionally Graded ◽  
Graded Materials ◽  
Beta Tricalcium Phosphate ◽  
Orthopedic Applications

Metallic biomaterials are widely used for implants and dental and orthopedic applications due to their good mechanical properties. Among all these materials, 316L stainless steel has gained special attention, because of its good characteristics as an implantable biomaterial. However, the Young’s modulus of this metal is much higher than that of human bone (~193 GPa compared to 5–30 GPa). Thus, a stress shielding effect can occur, leading the implant to fail. In addition, due to this difference, the bond between implant and surrounding tissue is weak. Already, calcium phosphate ceramics, such as beta-tricalcium phosphate, have shown excellent osteoconductive and osteoinductive properties. However, they present low mechanical strength. For this reason, this study aimed to combine 316L stainless steel with the beta-tricalcium phosphate ceramic (β-TCP), with the objective of improving the steel’s biological performance and the ceramic’s mechanical strength. The 316L stainless steel/β-TCP biocomposites were produced using powder metallurgy and functionally graded materials (FGMs) techniques. Initially, β-TCP was obtained by solid-state reaction using powders of calcium carbonate and calcium phosphate. The forerunner materials were analyzed microstructurally. Pure 316L stainless steel and β-TCP were individually submitted to temperature tests (1000 and 1100 °C) to determine the best condition. Blended compositions used to obtain the FGMs were defined as 20% to 20%. They were homogenized in a high-energy ball mill, uniaxially pressed, sintered and analyzed microstructurally and mechanically. The results indicated that 1100 °C/2 h was the best sintering condition, for both 316L stainless steel and β-TCP. For all individual compositions and the FGM composite, the parameters used for pressing and sintering were appropriate to produce samples with good microstructural and mechanical properties. Wettability and hemocompatibility were also achieved efficiently, with no presence of contaminants. All results indicated that the production of 316L stainless steel/β-TCP FGMs through PM is viable for dental and orthopedic purposes.

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