Evaluation of α-Tricalcium Phosphate Cement Obtained at Different Temperatures

2012 ◽  
Vol 727-728 ◽  
pp. 1187-1192 ◽  
Author(s):  
Rafaela Silveira Vieira ◽  
Wilbur Trajano Guerin Coelho ◽  
Mônica Beatriz Thürmer ◽  
Juliana Machado Fernandes ◽  
Luis Alberto Santos
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Calcium Pyrophosphate ◽  
In Vitro Test ◽  
Calcium Phosphate Cements ◽  
Similar Chemical ◽  
Different Temperatures ◽  
Vitro Test

The calcium phosphate cements (CPCs) based on α-tricalcium phosphate (α-TCP) are highly attractive for use in medicine and odontology, since they have similar chemical and phase composition of mineral phase of bones (calcium deficient hydroxyapatite (CDHA)). However, one of the biggest difficulties for use of this type of cement is its low mechanical strength due to the presence of undesirable phases, such as β-tricalcium phosphate. The route for obtaining α-TCP is at high temperature by solid state reaction, mixing calcium carbonate and calcium pyrophosphate. The aim of this work was to obtain calcium phosphate cements with improved strength, by studying the obtaining of α-TCP at temperatures of 1300, 1400 and 1500°C. The samples were analyzed by crystalline phases, pH, setting time, particle size, in vitro test (Simulated Body Fluid), porosity, density and compressive strength. The results show that the synthesis temperatures influence strongly the phases of powders obtained and the mechanical properties of cement, being unnecessary quenching for obtaining pure α-TCP.

Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphate/poly-dl-lactide-co-glycolide biocomposites and different phosphate materials

2006 ◽  
Vol 69 (12) ◽  
pp. 976-982 ◽  
Author(s):  
Nenad Ignjatović ◽  
Petar Ninkov ◽  
Vesna Kojić ◽  
Miloš Bokurov ◽  
Vladimir Srdić ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
In Vitro Test ◽  
Vitro Test

scholarly journals A novel ceramic material with medical application

2008 ◽  
Vol 2 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Joanna Podporska ◽  
Marta Błażewicz ◽  
Barbara Trybalska ◽  
Łukasz Zych
Keyword(s):  
Body Fluid ◽  
Crystallization Process ◽  
Sol Gel ◽  
Medical Application ◽  
In Vitro Test ◽  
Glass Crystallization ◽  
Complex Shapes ◽  
Different Temperatures ◽  
Vitro Test

Until now the basic methods used in manufacturing of wollastonite have been chemical (melting together with glass crystallization process, chemical coprecipitation) and sol - gel methods. A new and promising way of wollastonite fabrication is controlled pyrolysis of polysiloxane precursors with inorganic fillers. Heat treatment of such mixtures leads to the formation of wollastonite-containing ceramics already at about 1000?C. This is a relatively inexpensive and efficient method which enables to obtain complex shapes of the samples. The aim of this work was to obtain sintered, wollastonite-containing bioceramics and determine its bioactive features. Samples were sintered at three different temperatures: 1000, 1100 and 1200?C. Then the bioactivity of the wollastonite-containing ceramics was investigated by the ?in vitro? test in simulated body fluid. On the basis of the achieved results, it can be assumed that the obtained material possesses bioactive features.

scholarly journals Organic/Inorganic bioactive materials Part III: in vitro bioactivity of gelatin/silicocarnotite hybrids

2009 ◽  
Vol 7 (4) ◽  
pp. 721-730 ◽  
Author(s):  
Lachezar Radev ◽  
Maria Fernandes ◽  
Isabel Salvado ◽  
Daniela Kovacheva
Keyword(s):  
Calcium Phosphate ◽  
Hybrid Materials ◽  
Calcium Phosphates ◽  
Ceramic Powder ◽  
Structure Evolution ◽  
In Vitro Test ◽  
In Vitro Bioactivity ◽  
Bioactive Materials ◽  
Vitro Test

AbstractIn this work we present our experimental results on synthesis, structure evolution and in vitro bioactivity assessment of new gelatin/silicocarnotite hybrid materials. The hybrids were obtained by diluting gelatin (G) and silicocarnotite (S) ceramic powder with G:S ratios of 75:25 and 25:75 wt.% in hot (40°C) water. The hybrids were characterized using XRD, FTIR, SEM/EDS and XPS. FTIR depicts that the “red shift” of amide I and COO− could be attributed to the fact that the gelatin prefers to chelate Ca2+ from S. The growth of calcium phosphates on the surface of the hybrids synthesized and then immersed in 1.5 SBF for 3 days was studied by using of FTIR, XRD and SEM/EDS. According to FTIR results, after an immersion of 3 days, A and B-type CO3HA can be observed on the surface. XRD results indicate the presence of hydroxyapatite with well defined crystallinity. SEM/EDS of the precipitated layers show the presence of CO3HA and amorphous calcium phosphate on the surface of samples with different G/S content when immersed in 1.5 SBF. XPS of the G/S hybrid with 25:75 wt.% proved the presence of Ca-deficient hydroxyapatite after an in vitro test for 3 days.

scholarly journals Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres

2020 ◽  
Vol 21 (11) ◽  
pp. 3745
Author(s):  
Michiyo Honda ◽  
Yusuke Kawanobe ◽  
Kohei Nagata ◽  
Ken Ishii ◽  
Morio Matsumoto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bacterial Adhesion ◽  
Inflammatory Responses ◽  
Spray Pyrolysis Technique ◽  
Biological Properties ◽  
Histological Evaluation ◽  
Bone Apposition ◽  
Calcium Phosphate Cements

Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Silver-containing tricalcium phosphate (Ag-TCP) microspheres consisting of α/β-TCP phases were synthesized by an ultrasonic spray-pyrolysis technique. The powders prepared were mixed with the setting liquid to fabricate the CPCs. The resulting cements consisting of β-TCP and hydroxyapatite had a porous structure and wash-out resistance. Additionally, silver and calcium ions could be released into the culture medium from Ag-TCP cements for a long time accompanied by the dissolution of TCP. These data showed the bioresorbability of the Ag-TCP cement. In vitro antibacterial evaluation demonstrated that both released and immobilized silver suppressed the growth of bacteria and prevented bacterial adhesion to the surface of CPCs. Furthermore, histological evaluation by implantation of Ag-TCP cements into rabbit tibiae exhibited abundant bone apposition on the cement without inflammatory responses. These results showed that Ag-TCP cement has a good antibacterial property and good biocompatibility. The present Ag-TCP cements are promising for bone tissue engineering and may be used as antibacterial biomaterials.

scholarly journals PREPARATION AND IN VITRO TEST OF APATITE FILMS ONTO TITANIUM BY SPUTTERING FROM CALCIUM PHOSPHATE POWDER TARGETS

1999 ◽  
Vol 10 (0) ◽  
pp. 370-374
Author(s):  
JUN-ICHI HAMAGAMI ◽  
DAISUKE KOKUBU ◽  
KIYOSHI KANAMURA ◽  
TAKAO UMEGAKI ◽  
KIMIHIRO YAMASHITA
Keyword(s):  
Calcium Phosphate ◽  
In Vitro Test ◽  
Phosphate Powder ◽  
Vitro Test

scholarly journals Calcium Phosphate Cement Modified with Silicon Nitride/Tricalcium Phosphate Microgranules

2020 ◽  
Vol 20 (1) ◽  
pp. 56-75
Author(s):  
Lubomir Medvecky ◽  
Radoslava Stulajterova ◽  
Maria Giretova ◽  
Tibor Sopcak ◽  
Maria Faberova ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Silicon Nitride ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Controlled Drug Release ◽  
Tetracalcium Phosphate ◽  
Composite Cement ◽  
Highly Porous

Abstract Tetracalcium phosphate/monetite biocement was modified with 10 and 30 wt. % addition of highly porous silicon nitride/α-tricalcium phosphate (αTCP) microgranules with various content of αTCP. A composite cement powder mixture was prepared using mechanical homogenization of basic components. The accelerated release of dexamethasone from composite cement was revealed, which indicates their possible utilization for controlled drug release. The wet compressive strength of cements (<17 MPa) was significantly reduced (more than 30%) in comparison with the unmodified cement and both compressive strength and setting time were influenced by the content of αTCP in microgranules. The addition of microgranules caused a 20% decrease in final cement density. Microgranules with a higher fraction of αTCP showed good in vitro SBF bioactivity with precipitation of hydroxyapatite particles. Microstructure analysis of fractured cements demonstrated excellent interconnection between microgranules and cement calcium phosphate matrix, but also showed lower mechanical strength of microgranule cores.

Characterization of α/β-TCP Based Injectable Calcium Phosphate Cement as a Potential Bone Substitute

2012 ◽  
Vol 529-530 ◽  
pp. 157-160 ◽  
Author(s):  
Kemal Sariibrahimoglu ◽  
Joop G.C. Wolke ◽  
Sander C.G. Leeuwenburgh ◽  
John A. Jansen
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Setting Time ◽  
Surrounding Tissue ◽  
Calcium Phosphate Cements ◽  
Apatite Cement ◽  
Tcp Phase

Calcium phosphate cements (CPCs) can be a suitable scaffold material for bone tissue engineering because of their osteoconductivity and perfect fit with the surrounding tissue when injected in situ. However, the main disadvantage of hydroxyapatite (HA) forming CPC is its slow degradation rate, which hinders complete bone regeneration. A new approach is to use hydraulic apatite cement with mainly α/β-tricalciumphosphate (TCP) instead of α-TCP. After hydrolysis the α/β-TCP transforms in a partially non-absorbable HA and a completely resorbable β-TCP phase. Therefore, α-TCP material was thermally treated at several temperatures and times resulting in different α/β-TCP ratios. In this experiment, we developed and evaluated injectable biphasic calcium phosphate cements (BCPC) in vitro. Biphasic α/β-TCP powder was produced by heating α-TCP ranging from 1000-11250°C. Setting time and compressive strength of the CPCs were analyzed after soaking in PBS for 6 weeks. Results demonstrated that the phase composition can be controlled by the sintering temperature. Heat treatment of α-TCP, resulted in 100%, 75% and 25% of α-to β-TCP transformation, respectively. Incorporation of these sintered BCP powder into the cement formulation increased the setting time of the CPC paste. Compressive strength decreased with increasing β-TCP content. In this study, biphasic CPCs were produced and characterized in vitro. This injectable biphasic CPC presented comparable properties to an apatitic CPC.

scholarly journals Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

2015 ◽  
Vol 25 ◽  
pp. 347-355 ◽  
Author(s):  
Atsuo Ito ◽  
Yu Sogo ◽  
Atsushi Yamazaki ◽  
Mamoru Aizawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Test Methods ◽  
In Vitro Test ◽  
Calcium Phosphate Ceramics ◽  
Interlaboratory Studies ◽  
Vitro Test

Properties of Calcium Phosfate Cement with Addition of Dispersant and Hydrogel

2012 ◽  
Vol 727-728 ◽  
pp. 1170-1174 ◽  
Author(s):  
J.M. Fernandes ◽  
W.T. Coelho ◽  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
In Vitro Test ◽  
Polymeric Additives ◽  
Calcium Phosphate Bone Cement ◽  
Vitro Test ◽  
Good Biocompatibility

The calcium phosphate cements (CPCs) have attracted great interest for use in orthopedics and dentistry as replacements for damaged parts of the skeletal system,showing good biocompatibility and osseointegration. These characteristics allow its use as a bone graft.Several studies in literature have shown that the addition of polymeric additives has a strong influence on the mechanical properties of cement. The low mechanical strength is the main impediment to a broader use of calcium phosphate bone cement (CPCs) as implant material. The aim of this work was evaluate the strength of a CPC based on α-tricalcium phosphate, with polymeric additions. CPC was synthesized and sodium alginate were added (1%, 2% and 3% by weight) and ammonium polyacrylate (3%; dispersant) in aqueous solution. Specimens were molded and evaluated for density, pH, porosity, in vitro test (Simulated Body Fluid),crystalline phases and mechanical strength. The results show the increase of the mechanical properties of cement when added with sodium alginate and dispersant.

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