scholarly journals NEUROMUSCULAR ADAPTIONS FOLLOWING A DAILY STRENGTHENING EXERCISE IN INDIVIDUALS WITH ROTATOR CUFF RELATED SHOULDER PAIN: A PILOT CASE-CONTROL STUDY

2019 ◽  
Vol 14 (1) ◽  
pp. 74-87
Author(s):  
Amee L. Seitz ◽  
Lisa A. Podlecki ◽  
Emily R. Melton ◽  
Tim L. Uhl
Keyword(s):  
Rotator Cuff ◽  
Shoulder Pain ◽  
Case Control Study ◽  
Case Control ◽  
Strengthening Exercise ◽  
Control Study

Distinct Gene Expression Profile in Patients With Poor Postoperative Outcomes After Rotator Cuff Repair: A Case-Control Study

2021 ◽  
pp. 036354652110232
Author(s):  
Jessica M. Eager ◽  
William J. Warrender ◽  
Carly B. Deusenbery ◽  
Grant Jamgochian ◽  
Arjun Singh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rotator Cuff ◽  
Surgical Outcomes ◽  
Rotator Cuff Repair ◽  
Case Control Study ◽  
Case Control ◽  
Gene Sets ◽  
Poor Outcomes ◽  
Cuff Repair ◽  
Control Study

Background: Impaired healing after rotator cuff repair is a major concern, with retear rates as high as 94%. A method to predict whether patients are likely to experience poor surgical outcomes would change clinical practice. While various patient factors, such as age and tear size, have been linked to poor functional outcomes, it is currently very challenging to predict outcomes before surgery. Purpose: To evaluate gene expression differences in tissue collected during surgery between patients who ultimately went on to have good outcomes and those who experienced a retear, in an effort to determine if surgical outcomes can be predicted. Study Design: Case-control study; Level of evidence, 3. Methods: Rotator cuff tissue was collected at the time of surgery from 140 patients. Patients were tracked for a minimum of 6 months to identify those with good or poor outcomes, using clinical functional scores and follow-up magnetic resonance imaging to confirm failure to heal or retear. Gene expression differences between 8 patients with poor outcomes and 28 patients with good outcomes were assessed using a multiplex gene expression analysis via NanoString and a custom-curated panel of 145 genes related to various stages of rotator cuff healing. Results: Although significant differences in the expression of individual genes were not observed, gene set enrichment analysis highlighted major differences in gene sets. Patients who had poor healing outcomes showed greater expression of gene sets related to extracellular matrix production ( P < .0001) and cellular biosynthetic pathways ( P < .001), while patients who had good healing outcomes showed greater expression of genes associated with the proinflammatory (M1) macrophage phenotype ( P < .05). Conclusion: These results suggest that a more proinflammatory, fibrotic environment before repair may play a role in poor healing outcome. With validation in a larger cohort, these results may ultimately lead to diagnostic methods to preoperatively predict those at risk for poor surgical outcomes.

scholarly journals Genetics of rotator cuff tears: no association of col5a1 gene in a case-control study

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Katia Margiotti ◽  
Stefano Petrillo ◽  
Giacomo Rizzello ◽  
Caterina Fusilli ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Case Control Study ◽  
Case Control ◽  
Rotator Cuff Tears ◽  
Control Study

scholarly journals Performance After Rotator Cuff Tear and Operative Treatment: A Case-Control Study of Major League Baseball Pitchers

2011 ◽  
Vol 46 (3) ◽  
pp. 296-302 ◽  
Author(s):  
Surena Namdari ◽  
Keith Baldwin ◽  
Albert Ahn ◽  
G. Russell Huffman ◽  
Brian J. Sennett
Keyword(s):  
Rotator Cuff ◽  
Operative Treatment ◽  
Case Control Study ◽  
Major League Baseball ◽  
Case Control ◽  
Rotator Cuff Tears ◽  
Performance Variables ◽  
Major League ◽  
Rotator Cuff Surgery ◽  
Control Study

Context: Little is known about pitching performance or lack of it among Major League Baseball (MLB) pitchers who undergo operative treatment of rotator cuff tears. Objective: To assess pitching performance outcomes in MLB players who needed operative treatment of rotator cuff tears and to compare performance in these athletes with that in a control group of MLB players. Design: Case-control study. Setting: Publicly available player profiles, press releases, and team injury reports. Patients or Other Participants: Thirty-three MLB pitchers with documented surgery to treat rotator cuff tears and 117 control pitchers who did not have documented rotator cuff tears were identified. Main Outcome Measure(s): Major League Baseball pitching attrition and performance variables. Results: Players who underwent rotator cuff surgery were no more likely not to play than control players. Performance variables of players who underwent surgery improved after surgery but never returned to baseline preoperative status. Players who needed rotator cuff surgery typically were more experienced and had better earned run averages than control players. Conclusions: Pitchers who had symptomatic rotator cuff tears that necessitated operative treatment tended to decline gradually in performance leading up to their operations and to improve gradually over the next 3 seasons. In contrast to what we expected, they did not have a greater attrition rate than their control counterparts; however, their performances did not return to preoperative levels over the course of the study.

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