scholarly journals Therapeutic Effect Analysis of Sodium Aescinate Tablets on Knee Osteoarthritis Combined with Synovitis

2021 ◽  
Vol 5 (6) ◽  
pp. 1-6
Author(s):  
Xueqin Zeng ◽  
Baohui Wang ◽  
Liang Li ◽  
Tao Lei ◽  
Huajian Liu ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Therapeutic Effect ◽  
Knee Pain ◽  
Clinical Efficacy ◽  
Intervention Group ◽  
Control Group ◽  
Clinical Effects ◽  
Joint Function ◽  
Routine Treatment ◽  
The Difference

Objective: To observe therapeutic effect of sodium aescinate Tablets on knee osteoarthritis complicated with synovitis. Methods: 86 patients with knee osteoarthritis combined with synovitis treated in the Honghui Hospital Affiliated to Xi’an Jiaotong University from January 2018 to December 2019 were randomly divided into control group and intervention group, with 43 cases in each group. The control group was given routine treatment, and the intervention group was given sodium aescinate Tablets orally on the basis of routine treatment, twice a day, 2 tablets each time. The curative effect was evaluated after 2 weeks of treatment. The knee pain and joint function of the two groups were evaluated by Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC), and the clinical effects of the two groups were compared. Results: Before treatment, there was no significant difference in general information, VAS and WOMAC scores between the two groups (P > 0.05). After treatment, the VAS and WOMAC scores of the two groups were both lower than those before treatment, and the difference was statistically significant (P < 0.05). The vas and WOMAC scores of the intervention group were lower than those of the control group (VAS, 1.87 ± 0.79 vs 3.38 ± 0.81. In this study, sodium aescinate tablets were applied to the treatment of KOA combined with synovitis. The results showed that the intervention group was better than the control group in alleviating knee pain, improving joint function and improving clinical efficacy, and the difference was statistically significant. The total effective rate of the intervention group was higher than that of the control group (100% vs 86.05%), and the difference was statistically significant (P < 0.05). Conclusion: Sodium aescinate tablet in the treatment of knee osteoarthritis combined with synovitis can effectively alleviate knee pain, improve joint function and improve clinical efficacy.

scholarly journals Therapeutic Effect of Common Goldenrop Decoction Combined With Ramuli Cinnamomi Decoction in the Treatment of Patients with Insomnia during the Period of the Day from 11 PM to 3 AM

2020 ◽  
Vol 3 (1) ◽  
pp. 18
Author(s):  
Na Duan ◽  
Zhizhi Dong ◽  
Xiyou Qi
Keyword(s):  
Sleep Quality ◽  
Therapeutic Effect ◽  
Clinical Efficacy ◽  
Intervention Group ◽  
Effective Rate ◽  
Control Group ◽  
Short Term ◽  
The Difference

Objective: To observe the clinical efficacy of common goldenrop decoction combined with ramuli cinnamomi decoction in the treatment of patients with insomnia during the period of the day from 11 PM to 3 AM. Methods: 80 patients with insomnia during the period of the day from 11 PM to 3 AM were randomly divided into control group and intervention group. The control group was treated with 1 mg of estazolam tablets at 9 PM every night; while the intervention group was given common goldenrop decoction combined with ramuli cinnamomi decoction based on the estazolam tablets. After 2 weeks of treatment and after 2 weeks of withdrawal, the improvement in sleep was observed. Results: After 2 weeks of treatment, the efficacy of the intervention group (97.5%) was significantly higher than that of the control group (75.0%). The difference was statistically significant. After 2 weeks of withdrawal, the intervention group still had an effective rate of 87.5%, which was significantly higher than that of the control group (55.0%). Conclusion: common goldenrop decoction combined with ramuli cinnamomi decoction can improve the short-term and long-term sleep quality of patients with insomnia during the period of the day from 11 PM to 3 AM.

Serial Mud Packs Induce Anti-inflammatory Effects in Knee Osteoarthritis – A Randomized, Prospective Clinical Study

2020 ◽  
Author(s):  
Philipp Klemm ◽  
Gabriel Dischereit ◽  
Uwe Lange ◽  
Shaban Fetaj ◽  
Markus Ehnert
Keyword(s):  
Physical Therapy ◽  
Knee Osteoarthritis ◽  
Intervention Group ◽  
Secondary Outcome ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Clinical Effects ◽  
Outcome Parameters ◽  
Womac Index ◽  
Anti Inflammatory

Abstract Background Mud bath and pack have been used to treat musculoskeletal disorders since ancient times. However, the actual mechanisms of action of mud therapy on the inflammatory processes are complex and still not clarified. Methods Therefore, the clinical effects of serial mud packs in patients with knee osteoarthritis were investigated on the molecular level. A total of 52 patients were recruited from an in-patient rheumatology clinic. The participants were randomized in 2 groups: the intervention group (IG, n=26) underwent 9 mud packs in 21 days and a standardized multimodal physical therapy in an in-patient setting, whereas the control group (CG, n=26) only received the multimodal physical therapy. Primary outcome parameters were changes in the serum levels of interleukin(IL)-1ß and IL-10. Secondary outcome parameters were changes of the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Western Ontario and Mc Master Universities Arthritis (WOMAC) index and pain (visual analog scale - VAS). Results The IG presented after the serial mud packs significantly decreased pro-inflammatory IL-1ß levels and significantly increased anti-inflammatory IL-10 levels, whereas the CG showed no changes of the 2 cytokines. CRP and ESR remained within in the normal range in both groups without significant changes. Furthermore, the IG presented a significant decrease of the WOMAC index and pain (VAS). Conclusions The results suggest an additive anti-inflammatory effect of serial mud packs within a multimodal physical therapy concept in patients with knee osteoarthritis and could explain the beneficial clinical effects.

scholarly journals Efficacy and safety of celecoxib combined with JOINS in the treatment of degenerative knee osteoarthritis: study protocol of a randomized controlled trial

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110240
Author(s):  
Man Soo Kim ◽  
In Jun Koh ◽  
Yong Gyu Sung ◽  
Dong Chul Park ◽  
Sung Cheol Yang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Therapeutic Effect ◽  
Combination Treatment ◽  
Short Form ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Double Blind ◽  
Knee Oa ◽  
Anti Inflammatory

Background: The aim of this study will be to investigate the therapeutic effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) along with symptomatic slow-acting drugs for the treatment of osteoarthritis (SYSADOA), JOINS tablets, for degenerative knee osteoarthritis (OA) treatment and to determine the analgesic and anti-inflammatory effects of the combination therapy. In addition, we will investigate whether JOINS treatment alone after NSAID and JOINS combination treatment is effective in relieving and maintaining knee OA symptoms. Methods: This study will be a prospective, randomized, double-blind endpoint study design. All patients will be randomly assigned to either intervention (celecoxib+JOINS) or control (celecoxib+placebo) groups. In Part 1, the intervention group will be administered celecoxib once a day and JOINS three times a day for a total of 12 weeks. In the control group, celecoxib will be administered once a day and JOINS placebo three times a day for a total of 12 weeks. In Part 2, JOINS alone and JOINS placebo alone will be administered for an additional 24 weeks in both groups, respectively. The primary endpoint will be the amount of change during the 12 weeks as assessed using the Western Ontario and McMaster Universities Osteoarthritis Index total score compared with baseline. The secondary endpoint will be the amount of change at 1, 4, 12, 24, and 36 weeks from the baseline for pain visual analog scale, Brief Pain Inventory, Short Form Health Survey-36 and biomarkers. Results: The trial was registered with Clinical-Trials.gov (NCT04718649). The clinical trial was also registered on Clinical Research Information Service (CRIS) with the trial registration number KCT0005742. Conclusions: The combination treatment of the most commonly used SYSADOA drug, JOINS, and selective COX-2 inhibitor celecoxib as the representative NSAID for knee OA treatment, can be compared with celecoxib alone treatment to determine the safety or therapeutic effect.

scholarly journals The Effect of Nuhonni-Tulaar Rheumatic Exercise on Pain Reduction of Knee Osteoarthritis Patients

1970 ◽  
Vol 2 (01) ◽  
pp. 18-23
Author(s):  
Ferius Soewito ◽  
Siti Annisa Nuhonni ◽  
Elida Ilyas ◽  
Muchtaruddin Mansyur ◽  
Angela BM Tulaar
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Visual Analog Scale ◽  
Intervention Group ◽  
Control Group ◽  
Moderate Pain ◽  
Analog Scale ◽  
Mild Pain ◽  
Osteoarthritis Patient ◽  
Before And After

Objectives: Knee osteoarthritis patient has the risk for ambulation disability as a result of knee pain. Nuhonni-Tulaar rheumatic exercise was designed to prevent complications of rheumatic diseasesincluding knee osteoarthritis. The purpose of this study is to investigate the effectivity of Nuhonni-Tulaar rheumatic exercise to reduce pain of knee osteoarthritis patient.Methods: Twenty two subjects did the rheumatic exercise thrice a week in the gymnasium of medicalrehabilitation department Cipto Mangunkusumo hospital. Twenty other subjects, the control group, didthe standard hamstring stretching exercise at home. Each group performed the exercise for 8 weeks.Pain was measured using Visual Analog Scale (VAS) each week and analyzed before and after theintervention.Results: After 8 weeks VAS was reduced 1.5 in the intervention group while in the control group the reduction was 0.9. VAS was then transformed into no pain, mild pain, moderate pain and severepain. VAS was significantly reduced in the intervention group (p=0.002) but not in the control group (p=0.059). VAS changes between the two groups was significantly different (p=0.004).Conclusions: Rheumatic exercise has greater benefit in reducing pain than standard stretching exercise.Warming up, core exercise II and cooling down is safe and comfortable for knee osteoarthritis patientwith grade I-II Kellgren Lawrence radiographic grading.Keywords: Nuhonni-Tulaar Rheumatic exercise, Knee osteoarthritis, Visual Analog Scale

scholarly journals The effect of education based on Leventhal's model on adherence to treatment and control of blood pressure in patients with hypertension

2021 ◽  
Author(s):  
Mohammadreza Rajabloo ◽  
Ali Mohammadpour ◽  
Moosa Sajjadi
Keyword(s):  
Blood Pressure ◽  
Intervention Group ◽  
Control Group ◽  
Adherence To Treatment ◽  
Significance Level ◽  
Routine Treatment ◽  
Quasi Experimental ◽  
Pressure Record ◽  
The Difference ◽  
And Control

Background & Aim: Hypertension is a prevalent and significant health problem; moreover, lack of treatment adherence can cause precarious complications. The present study aims to determine the effect of education based on Leventhal's model on adherence to treatment and control of blood pressure in patients with hypertension. Methods & Materials: This quasi-experimental study was performed on 59 patients with hypertension in Gonabad in 2020. The participants were selected based on convenience sampling; they were randomly assigned to the intervention and control groups. In addition to the routine treatment for hypertension, the patients in the intervention group received a training program based on Leventhal's model in 45-minute sessions and three times a week. In contrast, the patients in the control group received only the routine treatment for hypertension. A demographic and Hill-Bone Adherence Questionnaires were completed for the participants. Moreover, their blood pressure was recorded using the blood pressure record form. The data were analyzed in SPSS v.22 software, at the significance level of p<0.05. Results: The two groups were homogeneous in adherence to treatment (P=0.63) before the intervention; yet, there was a substantial difference between the groups once the intervention was implemented (P<0.001). Besides, the average systolic and diastolic blood pressure was not significantly different between the two groups before the intervention. After the intervention, though, the difference was reported significant (p<0.05). Conclusion: Education based on Leventhal's model caused an improvement in adherence to treatment and reduced blood pressure among patients with hypertension.

scholarly journals Difference in patient-reported outcomes of various patellar component designs in total knee arthroplasty: A randomized clinical study

2021 ◽  
Vol 29 (1) ◽  
pp. 230949902199606
Author(s):  
Takeshi Mochizuki ◽  
Koichiro Yano ◽  
Katsunori Ikari ◽  
Ken Okazaki
Keyword(s):  
Knee Osteoarthritis ◽  
Clinical Effects ◽  
Patellar Component ◽  
American College Of Rheumatology ◽  
Randomized Clinical Study ◽  
Component Design ◽  
Patient Reported ◽  
Total Knee ◽  
The Difference ◽  
And Function

Purpose: This study investigated the clinical effects of different patellar components without being affected by the femoral component design in total knee arthritis (TKA) for patients with knee osteoarthritis (OA). Methods: In total, 48 patients with OA who met the criteria of the American College of Rheumatology for OA were enrolled and randomly assigned in a 1:1 ratio to two groups according to the usage of patellar component design for TKA (medialized dome type [dome group] or medialized anatomic type [anatomic group]). To evaluate the clinical outcomes for TKA, knee range of motion (ROM), pain intensity of 0–100 mm visual analog scale (pain VAS), and the Japanese Knee Osteoarthritis Measure (JKOM) score were obtained at baseline and year 1. Results: The difference in knee ROM, pain VAS, or total JKOM score at year 1 was not significant between the dome and anatomic groups ( p = 0.398, 0.733 and 0.536, respectively). Moreover, similar results were obtained for changes in knee ROM, pain VAS, or total JKOM scores from baseline. In both groups, the pain VAS and total JKOM scores were significantly improved at year 1. Conclusion: Both dome and anatomic groups in TKA are significantly effective for pain and function using the JKOM score. However, their efficacy did not differ, according to the JKOM score. Results of this study are rare information focusing on the patellar component design and provide one of the insights into the TKA clinical management.

scholarly journals The Effects of Acupuncture on Pregnancy Outcomes of Recurrent Implantation Failure: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Menglin Li ◽  
Yunyun Liu ◽  
Haoran Wang ◽  
Shuzhen Zheng ◽  
Yinhe Deng ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Intervention Group ◽  
Control Group ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
The Difference ◽  
Ivf Et

Objective. To systematically evaluate the efficacy and safety of acupuncture for patients with recurrent implantation failure (RIF) undergoing in vitro fertilization-embryo transfer (IVF-ET) and hopefully provide reliable guidance for clinicians and patients. Methods. Through searching domestic and foreign medical journals, the literature of randomized controlled trials (RCTs) of acupuncture for RIF undergoing IVF-ET was collected. RevMan 5.3 software was used for meta-analysis and Cochrane’s risk of bias assessment tool was used to evaluate the quality of the included studies. Results. Seven documents meeting the criteria were finally included. The results showed that the intervention group contributes more in outcomes including clinical pregnancy rate (RR = 1.90, 95% CI (1.51, 2.40), P < 0.05 ), biochemical pregnancy rate (RR = 1.59, 95% CI (1.27, 1.99), P < 0.05 ), embryo implantation rate (RR = 1.89, 95% CI (1.47, 2.45), P < 0.05 ), and endometrial thickness (MD = 1.11, 95% CI (0.59, 1.63), P < 0.05 ) when compared with the control group, and the difference is statistically significant. In terms of the number of embryo transfers and the type of endometrium, the difference between the acupuncture group and the control group was not statistically significant. Conclusion. Acupuncture therapy on patients with RIF can improve the pregnancy outcome of patients. It is a relatively effective treatment with satisfactory safety and suitable for clinical application. However, as the quality of the included studies is not good enough, the conclusion of this meta-analysis should be treated with caution. More double-blind RCTs equipped with high quality and large samples are expected for the improvement of the level of evidence.

scholarly journals Study on the clinical efficacy and mechanism of octreotide combined with thrombin in patients with liver

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Zhang Xiuqin
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Clinical Efficacy ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Before And After ◽  
Octreotide Treatment ◽  
The Difference ◽  
Treatment Observation

Objective: To observe the clinical efficacy of octreotide and thrombin in the treatment of patients with liver cirrhosis, and to explore the mechanism of octreotide and thrombin. Methods: 53 patients with cirrhosis were randomly divided into control group and observation group from January 2014 to January 2016. The control group of 26 patients, given octreotide treatment. Observation group of 27 cases, given octreotide and thrombin combination therapy. Comparison of two groups of patients with clinical efficacy and changes in liver function before and after treatment. Results: The effective rate (88.89%) in the observation group was significantly higher than that in the control group (65.38%), the difference was statistically significant (p < 0.05). Before treatment, the difference of liver function between the two groups was not statistically significant (p > 0.05). After treatment, the liver function indexes of the two groups were improved, and the observation group was superior to the control group, the difference was statistically significant (p < 0.05).

scholarly journals Nursing-Mini-CEX Combined with Online and Offline Hybrid Teaching Model Application Research in Basic Nursing Training Teaching

2020 ◽  
Vol 9 (6) ◽  
pp. 51
Author(s):  
Hongmin Wang ◽  
Yaru Feng ◽  
Huan Li
Keyword(s):  
Mixed Model ◽  
Intervention Group ◽  
Control Group ◽  
Teaching Model ◽  
Traditional Teaching ◽  
Training Methods ◽  
Hybrid Teaching ◽  
Measurement Tools ◽  
The Difference ◽  
Nursing Training

Objective: To explore the application effects and countermeasures of Nursing-Mini-CEX combined with the online and offline hybrid teaching model in basic nursing training. Methods: Taking 150 students from the 2017 grade as an example, the effects of traditional teaching mode and Nursing-Mini-CEX combined with mixed model teaching were compared. Results: The performance of the intervention group combining Nursing-Mini-CEX evaluation and mixed teaching was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The combination of Nursing-Mini-CEX measurement tools and mixed teaching is feasible and effective in basic nursing training.

scholarly journals Comparison of Short-Term Efficacy of Total Knee Arthroplasty Versus Arthroscopy in Chinese Patients with Knee Osteoarthritis

2020 ◽  
Author(s):  
Xiaolin Jia ◽  
San Cai ◽  
Wei Hu ◽  
Qiang Gan ◽  
Mingquan Zhou
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Osteoarthritis ◽  
Knee Arthroplasty ◽  
Scientific Basis ◽  
Knee Function ◽  
Chinese Patients ◽  
Control Group ◽  
Total Knee ◽  
The Difference ◽  
Experimental Group

Abstract Background: The purpose of this study was to compare the improvement of knee function in patients with knee osteoarthritis who underwent total knee arthroplasty and arthroscopy in China, and to provide a scientific basis for the application of clinical total knee arthroplasty in knee osteoarthritis.Methods: A total of 160 patients with knee osteoarthritis who were admitted to Chinese hospital from January 2017 to December 2018 were studied. They were divided into experimental group and control group according to their willingness of treatment. The control group was treated with arthroscopy and the experimental group was treated with total knee arthroplasty. All patients were followed for a period of 6 months. The knee joint function score (HSS), visual analog scale (VAS), and anxiety self-assessment scale (SAS) scores before and after surgery were compared between the two groups. Results: The proportion of "excellent or good" in the efficacy of the experimental group (91.25%) was higher than that of the control group (72.50%), and the difference was statistically significant (χ2=9.476, P<0.05). The HSS score of the experimental group was higher than that of the control group (P<0.05), while the VAS and SAS scores were lower than those of the control group (P<0.05). The scores of various SF-36 scales in the experimental group were higher than those in the control group after operation (P<0.05).Conclusions: Total knee arthroplasty was considered effective in treating patients with knee osteoarthritis that meet the indications, and is beneficial to improve knee function and reduce pain in patients. The surgical treatment also reduced the level of anxiety and effectively improve the quality of life of patients. Further investigation of its clinical application on treatment of knee osteoarthritis is warranted.

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