Role of Helicobacter pylori in the genesis of gastric ulcerations among smokers and nonsmokers

Helicobacter pylori infection was investigated by three different methods [serologically, microbiologically and biochemically] in 210 male patients aged 20-40 years. Gastric ulcers were diagnosed in 126 patients in which H. pylori infection showed a significant association X [2] = 162.8]. Smokers had a higher rate of infection than nonsmokers, both among patients with gastric ulcers [99% compared to 79%] and without. The risk of H. pylori infection was computed for different categories of smoker. Heavy cigarette smokers were found to have the highest risk, followed by moderate to mild cigarette smokers and communal shisha smokers;neither private shisha nor cigar/pipe smokers showed any significant risk

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Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

Infection and Immunity ◽

10.1128/iai.00479-16 ◽

2016 ◽

Vol 84 (12) ◽

pp. 3338-3349 ◽

Cited By ~ 11

Author(s):

Amber C. Beckett ◽

M. Blanca Piazuelo ◽

Jennifer M. Noto ◽

Richard M. Peek ◽

M. Kay Washington ◽

...

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Gastric Ulceration ◽

High Salt ◽

Gastric Ulcers ◽

Deficiency Anemia ◽

Content Type ◽

H Pylori

Epidemiologic studies have provided conflicting data regarding an association betweenHelicobacter pyloriinfection and iron deficiency anemia (IDA) in humans. Here, a Mongolian gerbil model was used to investigate a potential role ofH. pyloriinfection, as well as a possible role of diet, inH. pylori-associated IDA. Mongolian gerbils (eitherH. pyloriinfected or uninfected) received a normal diet or one of three diets associated with increasedH. pylorivirulence: high-salt, low-iron, or a combination of a high-salt and low-iron diet. In an analysis of all infected animals compared to uninfected animals (independent of diet),H. pylori-infected gerbils had significantly lower hemoglobin values than their uninfected counterparts at 16 weeks postinfection (P< 0.0001). The mean corpuscular volume (MCV) and serum ferritin values were significantly lower inH. pylori-infected gerbils than in uninfected gerbils, consistent with IDA. Leukocytosis and thrombocytosis were also detected in infected gerbils, indicating the presence of a systemic inflammatory response. In comparison to uninfected gerbils,H. pylori-infected gerbils had a higher gastric pH, a higher incidence of gastric ulcers, and a higher incidence of fecal occult blood loss. Anemia was associated with the presence of gastric ulceration but not gastric cancer. Infected gerbils consuming diets with a high salt content developed gastric ulcers significantly more frequently than gerbils consuming a normal-salt diet, and the lowest hemoglobin levels were in infected gerbils consuming a high-salt/low-iron diet. These data indicate thatH. pyloriinfection can cause IDA and that the composition of the diet influences the incidence and severity ofH. pylori-induced IDA.

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ASSOCIATION OF DUODENAL EOSINOPHILIC INFILTRATE WITH HELICOBACTER PYLORI INFECTION, BUT NOT WITH FUNCTIONAL DYSPEPSIA

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.202000000-13 ◽

2020 ◽

Vol 57 (1) ◽

pp. 74-78 ◽

Cited By ~ 1

Author(s):

Carine LEITE ◽

Luiz Edmundo MAZZOLENI ◽

Diego de Mendonça UCHOA ◽

Juliana Araújo CASTANHO ◽

Felipe MAZZOLENI ◽

...

Keyword(s):

Helicobacter Pylori ◽

Functional Dyspepsia ◽

Eosinophil Count ◽

Gastrointestinal Symptoms ◽

Duodenal Mucosa ◽

Helicobacter Pylori Infection ◽

Eosinophilic Infiltrate ◽

Urease Test ◽

H Pylori

ABSTRACT BACKGROUND: The role of Helicobacter pylori infection on eosinophilic infiltration in duodenal mucosa is poorly studied. An increase in the number of eosinophils in duodenum has been associated with functional dyspepsia. OBJECTIVE: To evaluate the influence of H. pylori infection on duodenal eosinophil count and the role of eosinophilic infiltrate of duodenum in functional dyspepsia. METHODS: Positive and negative H. pylori individuals were included. Both functional dyspeptic patients according to Rome III criteria (cases) and individuals without gastrointestinal symptoms (controls) were enrolled. They were submitted to upper endoscopy and H. pylori infection was verified by gastric histopathology and urease test. Eosinophils in the duodenal mucosa were counted in five high-power fields, randomly selected on slides of endoscopic biopsies. RESULTS: Thirty-nine H. pylori positive (mean age 40.5 and 69.2% women) and 24 negative patients (mean age 37.3 and 75% women) were included. The influence of the infection was observed in the duodenal eosinophil count, which was higher in infected individuals: median 13.2 vs 8.1 in non-infected individuals (P=0.005). When we analyzed patients according to symptoms, cases - mean age 39.6; 71.4% women - and controls - mean age 38.7; 71.4% women - had similar duodenal eosinophil count: median 11.9 and 12.6 respectively (P=0.19). CONCLUSIONS: We did not demonstrate association of duodenal eosinophil count with functional dyspepsia but found association with H. pylori infection.

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Role of Helicobacter pylori infection on delayed gastric liquid emptying in gastric ulcers

Gastroenterology ◽

10.1016/s0016-5085(03)83420-0 ◽

2003 ◽

Vol 124 (4) ◽

pp. A675

Author(s):

Toshihiko Hayakawa ◽

Hiroshi Kaneko ◽

Toshihiro Konagaya ◽

Kaori Shinozaki ◽

Akihito Iida ◽

...

Keyword(s):

Helicobacter Pylori ◽

Helicobacter Pylori Infection ◽

Gastric Ulcers

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Prevalence of Helicobacter pylori infection in sexual partners of H. pylori‐ infected subjects: Role of gastroesophageal reflux

United European Gastroenterology Journal ◽

10.1177/2050640618800628 ◽

2018 ◽

Vol 6 (10) ◽

pp. 1470-1476 ◽

Cited By ~ 7

Author(s):

Dolores Sgambato ◽

Giulio Visciola ◽

Emanuele Ferrante ◽

Agnese Miranda ◽

Lorenzo Romano ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastroesophageal Reflux ◽

Sexual Partners ◽

Helicobacter Pylori Infection ◽

H Pylori

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Current Therapy forHelicobacter pyloriInfection in Children and Adolescents

Canadian Journal of Gastroenterology ◽

10.1155/1999/634645 ◽

1999 ◽

Vol 13 (7) ◽

pp. 571-579 ◽

Cited By ~ 8

Author(s):

Benjamin D Gold

Keyword(s):

Health Care ◽

Helicobacter Pylori ◽

Consensus Conference ◽

Gastric Ulcers ◽

Current Therapy ◽

Consensus Conferences ◽

Gastroduodenal Disease ◽

Practical Guidelines ◽

H Pylori

Helicobacter pyloriinfects approximately 50% of the world’s population and is a definitive cause of gastroduodenal disease (ie, gastritis, duodenal and gastric ulcers) in children and adults. Four consensus conferences held around the globe have brought together clinicians, scientists, epidemiologists and health care economists to discuss the role of the gastric pathogenH pyloriin human gastroduodenal disease. At each of these conferences, the overriding objective was to reach a consensus on the development of practical guidelines for the diagnosis and treatment ofH pylori-infected individuals. However, it was not until the CanadianH pyloriConsensus Conference, held in November 1997, that the issues ofH pyloriinfection in children were addressed. Therapies forH pyloriinfection in children, presented in part at the First Canadian PaediatricH pyloriConsensus Conference, held in Victoria, British Columbia, November 1998, are reviewed in this paper.

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HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-70 ◽

2018 ◽

Vol 55 (3) ◽

pp. 279-282 ◽

Cited By ~ 2

Author(s):

Behnoush ASGARI ◽

Fatemeh KERMANIAN ◽

Nima DERAKHSHAN ◽

Mohammadreza ASNA-ASHARI ◽

Zahra Rouhani Nojede SADAT ◽

...

Keyword(s):

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Lactobacillus Rhamnosus ◽

Gastric Ulcers ◽

Main Role ◽

Intestinal Infection ◽

Mice Model ◽

Histologic Study ◽

H Pylori

ABSTRACT BACKGROUND: Helicobacter pylori (H. pylori) has been introduced by since 1983 by Marshal and Warren to play the main role in the pathophysiology of gastritis and gastric ulcers. Almost half of the world population1 is infected by H. pylori. Current therapeutic regimen against H. pylori includes the use of a proton pump inhibitor plus two or more antibiotics. However, the efficacy of this regimen is decreasing mainly due to antibiotic resistance and side effects of medications. This fact has resulted in public interest in other therapeutic options and the role of probiotics merits special attention in this regard. OBJECTIVE: This study aims to evaluate the efficacy of honey-derived Lactobacillus rhamnosus on H. pylori-induced gastric inflammation and gastro-intestinal infection in C57BL/6 Mice. METHODS: The 24 C57BL/6 Mice were randomly divided into three groups of eight mice each. All the mice were fed with 1cc suspension containing 5*1010 CFU/ mL of ATCC43504 strains of H. pylori for 3 consecutive days, twice daily via polyethylene gavage tubes. At the end of 4th week, infection with H. pylori was confirmed with stool Ag (ELISA) and following sacrifice of one mouse from each group, histopathologic study confirmed gastritis. The groups were subjected to different therapies as stated, 1: without Bismuth (Bi), Omeprazole (Om) and L. rhamnosus prescription, 2: Bi, Om and Clarithromycin (Cl) and 3: Bi, Om plus 1cc of suspension of 109 CFU/mL of L. rhamnosus. After 2 weeks, the stool was analyzed for Ag and the mice were sacrificed for evaluation of histopathologic changes. RESULTS: Treatment with L. rhamnosus group provided Zero titer of stool Ag and was associated with improved gastric inflammation in all subjects, similar to the clarithromycin group. CONCLUSION: Honey-derived L. rhamnosus probiotics provides similar results as clarithromycin in terms of improvement of H. pylori infection and gastritis in C57BL/6 Mice model, without its cons of antibiotic resistance.

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Higher Prevalence of Non-thyroidal-Illness Syndrome in Elderly Male Patients With Active Helicobacter pylori Infection

Frontiers in Medicine ◽

10.3389/fmed.2021.682116 ◽

2021 ◽

Vol 8 ◽

Author(s):

Banruo Sun ◽

Xuanping Wang ◽

Michael Edmund David McLarnon ◽

Yu Ding ◽

Miao Liu ◽

...

Keyword(s):

Helicobacter Pylori ◽

Thyroid Function ◽

Positive Association ◽

Apache Ii Score ◽

Thyroid Function Tests ◽

Elderly Male ◽

Male Cohort ◽

Male Patients ◽

H Pylori

Objective: It is currently unclear whether the Helicobacter pylori (H. pylori) infection leads to associated alterations in thyroid functions and thyroidal illnesses. This study aims to analyse this relationship in an elderly male cohort over a five-year period.Design: A case retrospective study.Methods: A longitudinal study was designed to collect subjects (≥65 years old) receiving both a thyroid examination and H. pylori infection status determined by 13C-urea breath test in 2013 at our unit. Subjects were followed every 1 to 2 years until December 2017 for laboratory results, visits to outpatient clinics/emergency departments etc. Blood tests and thyroid ultrasonography were performed to determine thyroid function and morphology.Results: 356 male subjects with mean age 78.5 ± 9.8 years were included. Active H. pylori infection was positive in 88 subjects (24.7%). Thyroid function tests and ultrasonography showed similar patterns between H. pylori positive and negative groups. Non-thyroidal-illness syndrome (NTIS) was diagnosed in 30/210 (14%) patients who experienced acute illnesses and hospitalization over five-year follow-up. Notably, NTIS demonstrated significantly higher prevalence in the H. pylori positive group compared to the negative group (17.1 vs. 5.6%, P = 0.001). Multivariate analysis showed that when age, APACHE II score and hemoglobin levels were adjusted, H. pylori status still has significant interrelationship with NTIS (OR = 3.497, P = 0.003).Conclusions: There is a positive association between chronic active H. pylori infection and NTIS prevalence in this elderly male cohort. Further studies are needed to elucidate the role of H. pylori infection on NTIS in elderly male patients.

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