HAES-LX-5% INFUSION-INDUCED STRUCTURAL CHANGES OF RATS’ RENAL CORTEX IN LATE PERIOD OF SKIN BURN INJURY

2017 ◽  
Vol 13 (61) ◽  
pp. 120
Author(s):  
T. V. Lachtadyr
Keyword(s):  
Structural Changes ◽  
Renal Cortex ◽  
Burn Injury ◽  
Late Period ◽  
Skin Burn

scholarly journals Structural changes of duodenal mucosa enterocytes of rats in burn skin injury under experimental streptozotocin-induced diabetes mellitus

2019 ◽  
Vol 25 (1) ◽  
pp. 55-61 ◽  
Author(s):  
V.G. Cherkasov ◽  
I.O. Tymoshenko
Keyword(s):  
Diabetes Mellitus ◽  
Mucous Membrane ◽  
Structural Changes ◽  
Burn Injury ◽  
Duodenal Mucosa ◽  
The Body ◽  
Experimental Simulation ◽  
Skin Burn ◽  
Streptozotocin Induced Diabetes ◽  
Experimental Group

The work is devoted to the study of structural changes of enterocytes in the mucous membrane of the duodenum in a burn injury of the skin of a rat under conditions of experimental streptozotocin induced diabetes. The study was carried out on laboratory white adult rats-males weighing 180-210 g. The control group consisted of 21 animals without somatic pathology, the first experimental group consisted of 21 rats with skin burn injury, the second experimental group cleared 21 rats with skin burn and experimental streptozotocin induced diabetes. A model of experimental diabetes mellitus was reproduced by administering streptozotocin intraperitoneally once in dose of 50 mg/kg to rats. In an experimental simulation of a skin burn, two copper plates in the form of an ellipse were kept in water at 100oC for 10 minutes and, under ether anesthesia conditions, were applied simultaneously symmetrically on both exposed parts of the body of rats with an exposure for 10 seconds. Burn skin damage in rats was II-AB degrees – dermal surface burn (according to the old classification III-A degree) with a total area of 21-23% of the body surface with the development of burn shock. For morphological studies, the duodenum was taken, fragments of which were processed using conventional light and electron microscopy. The main criteria for assessing damage the enterocytes of the duodenal mucosa were the results studies of histological and ultrastructural data over 7, 14 and 21 days after a skin burn. The results of the studies showed that the damage of the enterocytes of the duodenal mucosa is based on deep destructive changes, which after 21 days (at the stage of septic toxemia), as a rule, are not reversible and develop against the background of significant intoxication of the organism. In the mucous membrane of the duodenum with burn injury of the skin associated with diabetes mellitus, there is a deterioration of the manifestations of the adaptive response and prolongation of destructive processes, accompanied by a violation of intercellular interactions in cytoarchitectically modified and deformed villi and crypts.

Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury

2011 ◽  
Vol 8 (1) ◽  
pp. 184-194 ◽  
Author(s):  
Justyna Drukała ◽  
Edyta Paczkowska ◽  
Magda Kucia ◽  
Elżbieta Młyńska ◽  
Andrzej Krajewski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Blood ◽  
Burn Injury ◽  
Skin Burn

Reflectometry Enhancement by Saline Injection in Microwave-based Skin Burn Injury Diagnosis

2020 ◽  
Author(s):  
Alireza Madannejad ◽  
Javad EbrahimiZadeh ◽  
Fatemeh Ravanbakhsh ◽  
Mauricio D Perez ◽  
Robin Augustine
Keyword(s):  
Burn Injury ◽  
Saline Injection ◽  
Skin Burn

Polyunsaturated Phosphatidylcholine Protects Against Wound Contraction in Experimental Skin Burn Injury

2004 ◽  
Vol 17 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Turan Kanmaz ◽  
Hamdi Karakayali ◽  
A. Ebru Sakallioglu ◽  
B. Handan Ozdemir ◽  
Mehmet Haberal
Keyword(s):  
Burn Injury ◽  
Wound Contraction ◽  
Skin Burn ◽  
Polyunsaturated Phosphatidylcholine

scholarly journals Comparative characteristics of the manifestations of damage and reparative processes in the mucous membrane of the duodenum of rats under the conditions of skin burns and skin burns associated with diabetes

2020 ◽  
Vol 26 (2) ◽  
pp. 39-44
Author(s):  
I.A. Tymoshenko ◽  
L.M. Sokurenko ◽  
A.Ya. Yanchyshyn ◽  
V.A. Pastukhova
Keyword(s):  
Diabetes Mellitus ◽  
Mucous Membrane ◽  
Structural Changes ◽  
Burn Injury ◽  
Experimental Diabetes ◽  
Male Rats ◽  
Control Group ◽  
Experimental Diabetes Mellitus ◽  
Buffer Solution ◽  
Solution Ph

Currently, severe thermal injury is becoming one of the most important problems of practical medicine. Diabetes is also recognized as another global medical and social challenge of our century. The emergency situation for the treatment and prevention of the consequences of these pathologies is a consequence of the lack of a reliable theoretical basis for solving specific clinical problems regarding the course of burns, diabetes and their complications. The aim of the study is to establish the patterns of structural changes in the mucous membrane of the duodenum after burn injury of the skin of rats under conditions of experimental diabetes mellitus. The study was performed on 63 laboratory white adult male rats weighing 180-210 g, which were divided into 3 groups: intact animals, rats with skin burns and rats with skin burns on the background of diabetes. The model of experimental diabetes mellitus was reproduced by administering Streptozotocin to rats intraperitoneally once at a dose of 50 mg/kg, pre-dissolved in 0.1 M citrate buffer solution (pH=4.5). The control of the development of hyperglycemia in the experimental groups was the level of glucose in the blood 24.24±0.79 mmol/l. In the control group this index was 8.03±0.4 mmol/l. Rats with skin burns revealed destructive manifestations, which are accompanied by an active inflammatory reaction and corresponding necrotic changes, while rats with skin burns on the background of diabetes mellitus pathological processes are not just “summed up”, but in some way adaptively modified with the involvement of stress mechanisms of the endoplasmic reticulum and associated autophagy.

scholarly journals STRUCTURAL REARRANGEMENT OF THE ORGANS OF THE NEUROIMUNOENDOCRINE SYSTEM IN CONDITIONS OF BURN DISEASE

2020 ◽  
Vol 19 (3) ◽  
pp. 27-34
Author(s):  
O. Kovalchuk ◽  
I. Gunas
Keyword(s):  
Adrenal Cortex ◽  
Structural Transformation ◽  
Structural Changes ◽  
Burn Injury ◽  
Morphological Changes ◽  
Vascular Wall ◽  
Plastic Property ◽  
Structural Rearrangement ◽  
Wide Range ◽  
Burn Disease

The relevance of this study is due to the lack of special studies, the subject of which is the analysis of indicators of endogenous intoxication and structural changes in the histohematological barriers of the organs of the neuroimunoendocrine system in burn disease under conditions of its treatment by infusion of colloidal hyperosmolar solutions. It was found that changes in the permeability of the vascular wall and death of endothelial cells are of particular importance in the development of morphological changes in the adenohypophysis, adrenal cortex and thymus, which at the final stage of these reactions causes the appearance of intraorganic edema and hemorrhage characteristic of burn injury. It can be argued that there is a specific, but common for all studied organs, mechanism of transformation of histohematogenous barriers, which consists in the formation, under the influence of Lactoprotein-C, of a structured, branched, membrane-like complex in a certain way. Its components provide not only strengthening of the vascular wall, but also the isolation of cell clusters. So, the data obtained indicate not the restoration of the structure of histohematogenous barriers, but their structural transformation, which leads to the appearance of a new formation - a membranelike complex, which effectively provides the necessary barrier function. The leading factor of damage to histohematogenous barriers in the studied organs in burn disease is a wide range of morphofunctional changes in the vascular endothelium, which cause the formation of through transmural defects in the wall of blood vessels and the corresponding intraorgan intercellular expansions, the marker of which is the electron-dense Lactoprotein-C. Lactoprotein-C and HAES-LX-5% under conditions of burn disease develop cyto- and angioprotective effects, inhibit the development of hemorrhages, edema, prevent alteration of cells of the adenohypophysis, adrenal cortex and thymus and promote organ repair. Lactoprotein-C is characterized by the first described membrane-plastic property, which ensures the implementation of a specific mechanism of structural transformation of histohematogenous barriers, namely, the creation of a branched membrane-like complex.

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