scholarly journals Clinic-morphological diagnosis of Barrett’s esophagus

2018 ◽  
Vol 85 (7) ◽  
pp. 9-12 ◽  
Author(s):  
O. G. Кuryk ◽  
М. Yu. Коlomoiets ◽  
V. О. Yakovenko ◽  
Т. V. Теreshchenko Т. V. Теreshchenko ◽  
R. P. Тkachenko
Keyword(s):  
Confidence Interval ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Objective Criterion ◽  
Disease Prognosis ◽  
Morphological Diagnosis ◽  
Endoscopic Investigation ◽  
Objective Determination ◽  
Selection Of

Objective. Determination of efficacy of morphological diagnosis of the Barrett’s esophagus (BE). Маterials and methods. Diagnosis of BE in accordance to data obtained during screening endoscopic investigation with biopsy and morphological verification in 2014 - 2016 yrs, basing on Medical Centre «University Clinic «Оberig», Kyiv, was analyzed. Results. BE was diagnosed in 841 (36.8%) patients (95% of confidence interval (CІ) 36.02 – 39.76) among 2405 patients, in whom esophagogastroscopy was conducted. Histologically cardiac metaplasia was revealed in 48 (5.71%) patients, fundic - in 136 (16.19%), intestinal specialized - in 625 (72.28%), and the mixed - in 32 (3.81%) patients. Dysplasia of high and low grades was diagnosed in 32 (3.81%) (95% CІ 2.04 – 4.62), including: in 24 (75.0%) - low, and in 8 (25.0%) – high. Аdenocarcinoma was revealed in 4 (0.47%) patients (95% CІ 0.20 – 1.36). Conclusion. Мorphological verdict constitutes the main and objective criterion for the BE verification, what is important for selection of the treatment tactics and certainly help to determine the disease prognosis.

Tu1162 Volumetric Laser Endomicroscopy Guides Both Selection of Ablative Modality and Tissue Sampling During Ongoing Therapy of Barrett's Esophagus

2016 ◽  
Vol 83 (5) ◽  
pp. AB560-AB561
Author(s):  
Virendra Joshi ◽  
Brooks D. Cash ◽  
Matthew McKinley ◽  
Paul R. Tarnasky ◽  
Kenneth J. Chang ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Tissue Sampling ◽  
Selection Of

scholarly journals Instrumental selection of tooth color in prosthodontic rehabilitation

2007 ◽  
Vol 54 (4) ◽  
pp. 240-247 ◽  
Author(s):  
Slobodan Djurisic ◽  
Aleksandra Milic-Lemic ◽  
Kosovka Obradovic-Djuricic ◽  
Olga Popovic
Keyword(s):  
Basic Principles ◽  
Tooth Color ◽  
Color Selection ◽  
Successful Rehabilitation ◽  
Objective Determination ◽  
Selection Of

Tooth color selection in prosthodontics is a very important factor for successful rehabilitation. The aim of this paper was to present different instruments for tooth color selection in prosthodontic rehabilitation. Knowledge of basic principles of a complex psychophysical phenomenon such as color is of essential interest in prosthodontic therapy. Furthemore, the mechanism of physiological perception of color and available methods for an objective determination of tooth color are also presented in the paper.

scholarly journals Efficacy of Cryotherapy as a Primary Endoscopic Ablation Modality for Dysplastic Barrett’s Esophagus and Early Esophageal Neoplasia: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482097666
Author(s):  
Raseen Tariq ◽  
Sarah Enslin ◽  
Maham Hayat ◽  
Vivek Kaul
Keyword(s):  
Confidence Interval ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Meta Analysis ◽  
Primary Treatment ◽  
Systemic Review ◽  
Primary Therapy ◽  
Esophageal Neoplasia ◽  
Substantial Heterogeneity

Introduction: Cryotherapy is a cold-based ablative therapy used primarily as second line therapy in patients with Barrett’s esophagus (BE) who have persistent dysplasia after undergoing endoscopic treatment with radiofrequency ablation (RFA). Few studies have described the use of cryotherapy as a primary treatment modality for dysplastic or neoplastic BE. Aim: To evaluate the efficacy of cryotherapy as primary treatment of dysplastic and/or neoplastic BE by conducting a systemic review and meta-analysis. Methods: A systematic search of Medline, Embase, and Web of Science was performed from January 2000 through March 2020. Articles included were observational studies and clinical trials which included patients who had biopsy confirmed dysplastic or neoplastic BE (i.e., high grade dysplasia (HGD), low grade dysplasia (LGD) or intramucosal adenocarcinoma (ImCA)), underwent ≥1 session of cryotherapy, and had a follow-up endoscopy. Primary outcomes were pooled proportions of patients achieving complete eradication of dysplasia (CE-D) and/or intestinal metaplasia (CE-IM) by using a random effects model. Results: Fourteen studies making up 405 patients with follow-up ranging from 3-54 months were included. In 13 studies, a total of 321/405 patients achieved CE-D with a pooled proportion of 84.8% (95% confidence interval [CI] 72.2-94.4), with substantial heterogeneity (I2 = 88.3%). In 13 studies, a total of 321/405 patients achieved CE-D with a pooled proportion of 84.8% (95% confidence interval [CI] 72.2-94.4), with substantial heterogeneity (I2 = 88.3%). Subgroup analysis of only high-quality studies revealed a pooled proportion of CE-D 91.3% (95% CI, 83.0-97.4, I2 = 69.5%) and pooled proportion of CE-IM of 71.6% (95% CI, 59.0-82.9, I2 = 80.9%). Adverse events were reported in 12.2% patients. Conclusion: Cryotherapy is a safe and effective primary therapy for dysplastic/early neoplastic BE. CE-D and CE-IM rates are comparable to those for other ablation modalities, including RFA. Cryotherapy should be considered for primary therapy of dysplastic BE and early esophageal neoplasia.

Videoconference microscopy is a reliable alternative to conventional microscopy in the evaluation of Barrett’s esophagus: Zooming into a new era

2021 ◽  
Author(s):  
Page Axley ◽  
Rachel Mitchell ◽  
Leona Council ◽  
Chirag Patel ◽  
Jessica Tracht ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Gastroesophageal Junction ◽  
Weighted Kappa ◽  
Observer Agreement ◽  
Histological Evaluation ◽  
Low Grade ◽  
Good Reliability ◽  
Conventional Microscopy

Abstract Telepathology, practicing pathology from a distance, allows experts to review cases without the need to transfer glass slides. Due to significant intra- and inter-observer variabilities in the histological evaluation of Barrett’s esophagus (BE), current guidelines recommend expert consultation in cases of dysplasia. We aimed to determine whether telepathology using microscope videoconferencing can be reliably used for evaluation of BE. Biopsies from 62 patients with endoscopic findings of salmon colored mucosa extending ≥1 cm proximal to the gastroesophageal junction were randomly selected to represent benign esophagus, non-dysplastic BE, low-grade dysplasia, high-grade dysplasia, and adenocarcinoma. Three gastrointestinal-trained pathologists reviewed the cases via videoconference microscopy followed by conventional microscopy. Intra-observer and pairwise inter-observer agreements between the conventional microscopy and videoconference methodologies were calculated for each of the three pathologists using Fleiss-Cohen weighted kappa (K) analysis. The intra-observer agreement for each pathologist’s assessment of videoconference microscopy and glass slide readings showed very good reliability (K = 0.94, 95% confidence interval = 0.89–0.99; 0.88, 95% confidence interval = 0.79–0.98; 0.93, 95% confidence interval = 0.90–0.97). Mean pairwise inter-observer agreement was 0.90 for videoconference and 0.91 for conventional microscopy. Diagnosis and grading of BE using videoconference microscopy show similar reliability as conventional microscopy. Based on our findings, we propose that videoconferencing pathology is a valid instrument for evaluating BE.

scholarly journals CDX2, COX2 and MUC2 Expressions in Barrett's Esophagus: Can They Be Useful in Determination of the Dysplasia?

2012 ◽  
Vol 28 (3) ◽  
pp. 251 ◽  
Author(s):  
Ilknur Cetinaslan Turkmen ◽  
Nuray Bassullu ◽  
Suleyman Uraz ◽  
Mehmet Ali Yerdel ◽  
Resat Memisoglu ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus

scholarly journals Esophageal abnormalities and the risk for gastroesophageal cancers—a histopathology-register-based study in Sweden

2022 ◽  
Author(s):  
Isabella Ekheden ◽  
Jonas F. Ludvigsson ◽  
Li Yin ◽  
Peter Elbe ◽  
Weimin Ye
Keyword(s):  
General Population ◽  
Confidence Interval ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Population Based ◽  
Low Grade ◽  
Gastric Cardia Adenocarcinoma ◽  
Increased Risk ◽  
Columnar Metaplasia

Abstract Background The poor survival of patients with gastroesophageal cancers may improve if additional esophageal precursor lesions to Barrett’s esophagus and squamous dysplasia are identified. We estimated the risk for gastroesophageal cancers among patients with various histopathological abnormalities in the esophagus, including Barrett’s esophagus, subdivided by histopathological types. Methods Histopathology data from esophageal biopsies obtained 1979–2014 were linked with several national population-based registers in Sweden. Patients were followed from 2 years after the first biopsy date until cancer, death, emigration, esophagectomy/gastrectomy or end of follow-up, 31st of December 2016, whichever came first. We estimated standardized incidence ratios (SIRs) as measures of relative risk with the Swedish general population as reference. Results In total 367 esophageal adenocarcinoma (EAC) cases were ascertained during 831,394 person-years of follow-up. The incidence rate (IR) for EAC was 0.1 per 1000 person-years for normal morphology, 0.2–0.5 for inflammatory changes, and 0.8–2.9 for metaplasia. The IR was 1.0 per 1000 person-years (95% confidence interval 0.7–1.3) among patients with non-dysplastic intestinal metaplasia, 0.9 (0.8–1.1) in non-dysplastic gastric/glandular metaplasia and 2.9 (2.0–4.2) among columnar metaplasia patients with low-grade dysplasia. The SIRs were 11.7 (95% confidence interval 8.6–15.5), 12.0 (10.0–14.2) and 30.2 (20.5–42.8), respectively. The SIRs for gastric cardia adenocarcinoma (GCA) were moderately elevated. Conclusions For the first time, we demonstrate that patients with esophageal inflammatory and other metaplastic abnormalities than Barrett’s esophagus have an increased risk of EAC and GCA compared to the general population. Moreover, patients with different histopathologic subtypes of Barrett’s esophagus have a comparable risk for EAC.

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