PROFILE OF ESOPHAGUS NEOPLASMS RELATED TO THE CONSUMPTION OF ALCOHOLIC BEVERAGES:

Introduction: Esophageal neoplasia presents a high morbidity and mortality rate, associated with males and the esolist habit. Objective: to describe the profile of esophageal neoplasia related to alcohol consumption between 2015 and 2019 in Montes Claros, Minas Gerais, Brazil. Methods: A descriptive study of quantitative approach was conducted through data from patients diagnosed with esophageal neoplasia in hospital records of the José Alencar Gomes da Silva National Cancer Institute (INCA). Results and discussion: 525 cases of esophageal neoplasia were recorded in the period evaluated. Alcohol consumption was positive in 88.1% of the cases. Conclusion: The data indicate a positive relationship between alcohol consumption and esophageal neoplasia. These data should encourage the establishment of public policies for health education measures in relation to alcohol consumption and smoking habits.

Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

Esophageal cancer (EC) is a common malignant tumor of the upper digestive tract. The microbiota in the digestive tract epithelium comprises a large number of microorganisms that adapt to the immune defense and interact with the host to form symbiotic networks, which affect many physiological processes such as metabolism, tissue development, and immune response. Reports indicate that there are microbial compositional changes in patients with EC, which provides an important opportunity to advance clinical applications based on findings on the gut microbiota. For example, microbiota detection can be used as a biomarker for screening and prognosis, and microorganism levels can be adjusted to treat cancer and decrease the adverse effects of treatment. This review aims to provide an outline of the gut microbiota in esophageal neoplasia, including the mechanisms involved in microbiota-related carcinogenesis and the prospect of utilizing the microbiota as EC biomarkers and treatment targets. These findings have important implications for translating the use of gut microbiota in clinical applications.

Minimal Associations between Short-Term Dietary Intake and Salivary Microbiome Composition

Background: Increasing evidence points to the esophageal microbiome as an important co-factor in esophageal neoplasia. Esophageal microbiome composition is strongly influenced by the oral microbiome. Salivary microbiome assessment has emerged as a potential non-invasive tool to identify patients at risk for esophageal cancer, but key host and environmental factors that may affect the salivary microbiome have not been well-defined. This study aimed to evaluate the impact of short-term dietary intake on salivary microbiome composition. Methods: Saliva samples were collected from 69 subjects prior to upper endoscopy who completed the Automated Self-Administered 24-Hour (ASA24) Dietary Assessment. Salivary microbiome composition was determined using 16S rRNA amplicon sequencing. Results: There was no significant correlation between alpha diversity and primary measures of short-term dietary intake (total daily calories, fat, fiber, fruit/vegetables, red meat intake, and fasting time). There was no evidence of clustering on beta diversity analyses. Very few taxonomic alterations were found for short-term dietary intake; an increased relative abundance of Neisseria oralis and Lautropia sp. was associated with high fruit and vegetable intake, and an increased relative abundance of a taxon in the family Gemellaceae was associated with increased red meat intake. Conclusions: Short-term dietary intake was associated with only minimal salivary microbiome alterations and does not appear to have a major impact on the potential use of the salivary microbiome as a biomarker for esophageal neoplasia.