scholarly journals Injuries of ductus thoracicus

2020 ◽  
Vol 87 (7-8) ◽  
pp. 20-24
Author(s):  
І. D. Duzhyi ◽  
O. M. Lytvynenko ◽  
S. О. Holubnichyi ◽  
О. L. Sytnik ◽  
V. Ya. Pak ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Malignant Tumor ◽  
Final Diagnosis ◽  
Thoracic Injury ◽  
Histological Investigation ◽  
Ductus Thoracicus ◽  
Specialized Treatment

Objective. To study peculiarities of course and diagnosis of traumatic and spontaneous injuries of ductus thoracicus. Маterials and methods. Ten patients, suffering chylothorax, were observed and examined, using thoracoscopy, аnd exudate - using test with sudan ІІІ. Results. In 6 patients the injuries of ductus thoracicus were revealed: in 1 patient - direct, in 1 - iatrogenic, and in 4 - spontaneous. In 4 patients chylothorax presented a symptom of other diseases. Conclusion. Diagnostic-treatment tactics, if the ductus thoracic injury and presence of chylothorax are suspected, ought to be following: analysis of anamnesis - pleural puncture - exudate aspiration - investigation, directed on identification of the malignant tumor cells and mycobacteria of tuberculosis - test with sudan ІІІ - thoracoscopy - pleurobiopsy - histological investigation - final diagnosis - specialized treatment (оperative-conservative).

CYTOLOGICAL AND IMMUNOCYTOCHEMICAL DIAGNOSIS OF TUMOR PLEURITIS

2017 ◽  
Vol 63 (6) ◽  
pp. 894-899
Author(s):  
Viktor Novik ◽  
A. Nefedova ◽  
Ye. Yakubo ◽  
O. Ivanov ◽  
Yekaterina Shalina ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Malignant Tumor ◽  
Cytological Study ◽  
False Negative ◽  
Unknown Primary ◽  
Cytological Examination ◽  
Immunocytochemical Studies ◽  
Negative Conclusion ◽  
Primary Localization

Cytological examination of smears from the sediment after centrifugation of pleural fluids was performed in 479 patients who underwent examination and treatment at our institution in 2014-2016. In 249 (52%) patients tumor cells were not detected in smears, in 230 (48%) observations a suspicion (28 observations) or a confident conclusion (202 observations) on the presence of malignant tumor cells in the exudates was cytologically expressed. In 38 cases immunocytochemical studies was additionally performed. In two observations a false-negative conclusion about the absence of tumor cells in smears was expressed. The sensitivity of the cytological study in the diagnosis of malignant pleuritis was 99.0%. Affirmative cytological conclusions on the presence of malignant pleuritis were given in 87.0% of observations, suspicious cytological responses - in 12.0% of cases. Immunocytochemical studies significantly expanded the possibilities of cytological research and were of great importance in the diagnosis of metastases of tumors of unknown primary localization.

High-throughput concentration of rare malignant tumor cells from large-volume effusions by multistage inertial microfluidics

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Nan Xiang ◽  
Zhonghua Ni
Keyword(s):  
Tumor Cells ◽  
High Throughput ◽  
Malignant Tumor ◽  
Large Volume ◽  
Concentration Factor ◽  
Pleural Effusions ◽  
Inertial Microfluidics ◽  
Low Concentration ◽  
Malignant Pleural Effusions ◽  
On Chip

On-chip concentration of rare malignant tumor cells (MTCs) in malignant pleural effusions (MPEs) with a large volume is challenging. Previous microfluidic concentrators suffer from a low concentration factor (CF) and...

scholarly journals VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin

2019 ◽  
Author(s):  
Daniel Delgado-Bellido ◽  
Concepción Bueno-Galera ◽  
Angel Garcia-Diaz ◽  
F. Javier Oliver
Keyword(s):  
Endothelial Cells ◽  
Malignant Melanoma ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Vasculogenic Mimicry ◽  
P120 Catenin ◽  
Human Malignant Melanoma ◽  
Aberrant Phenotype ◽  
Autophagic Degradation ◽  
Vascular Expression

AbstractAberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone (VM+) tumor cells VE-cadherin is mainly in the form of pVE-cadherin in Y658 allowing an increased plasticity that potentiates VM development. As excessive VE-cadherin phosphorylation is regulated by the phosphatase VEPTP in endothelial cells in the current study we analysed its role in this aberrant phenotype in malignant tumor cells. We show that human malignant melanoma cells VM+, also express VE-PTP although at lower levels than endothelial cells. The complex VE-PTP/VE-Cadherin/p120-catenin act as a safeguard to prevent VE-cadherin degradation by autophagy. Indeed, silencing of VE-PTP results in complete degradation of VE-cadherin with the features of autophagy and increases the global p120 tyrosine phosphorylation status. In summary, we show that VE-PTP is involved in VM formation and disruption of VE-PTP/VE-Cadherin/p120 complex results in enhanced autophagy in aggressive VM+ cells.

scholarly journals Extraneural metastases in medulloblastoma

2011 ◽  
Vol 69 (2b) ◽  
pp. 328-331 ◽  
Author(s):  
V M F Muoio ◽  
S O Shinjo ◽  
H Matushita ◽  
S Rosemberg ◽  
M J Teixeira ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Ventriculoperitoneal Shunt ◽  
Clinical Profile ◽  
Invasive Growth ◽  
Extraneural Metastases

Medulloblastoma is the most common childhood malignant tumor of central nervous system, but it may also occur in adults. It presents high invasive growth with spreading of tumor cells into the leptomeningeal space along the neuroaxis early in the course of the disease. Extraneural metastases are rare but frequently lethal, occurring only in 1 to 5% of patients, and are related, in the most of cases, to the presence of ventriculoperitoneal shunt. Here we characterize the clinical profile of five cases of medulloblastoma with systemic spreading of tumor cells, also comparing them to cases already described in the literature.

A study of the localization of transferrin receptor in malignant tumor cells

1995 ◽  
Vol 28 (3-4) ◽  
pp. 172-180 ◽  
Author(s):  
Yutaka Kimijima ◽  
Nobuyuki Tanaka ◽  
Yoshinobu Eishi ◽  
Takao Miyamoto ◽  
Kenichi Shionoya ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Malignant Tumor ◽  
Transferrin Receptor

Non-apoptotic cell death in malignant tumor cells and natural compounds

2018 ◽  
Vol 420 ◽  
pp. 210-227 ◽  
Author(s):  
Jing Ye ◽  
Ruonan Zhang ◽  
Fan Wu ◽  
Lijuan Zhai ◽  
Kaifeng Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Apoptotic Cell ◽  
Natural Compounds ◽  
Apoptotic Cell Death

Cancer and Signaling Pathway Deregulation

2011 ◽  
pp. 369-379
Author(s):  
Yingchun Liu
Keyword(s):  
Cancer Patients ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Molecular Mechanisms ◽  
Complex Disease ◽  
Cancer Therapies ◽  
Normal Cells ◽  
Genetic Aberrations ◽  
Cancer Subtypes ◽  
Pathway Deregulation

Cancer is a complex disease that is associated with a variety of genetic aberrations. The diagnosis and treatment of cancer have been difficult because of poor understanding of cancer and lack of effective cancer therapies. Many studies have investigated cancer from different perspectives. It remains unclear what molecular mechanisms have triggered and sustained the transition of normal cells to malignant tumor cells in cancer patients. This chapter gives an introduction to the genetic aberrations associated with cancer and a brief view of the topics key to decode cancer, from identifying clinically relevant cancer subtypes to uncovering the pathways deregulated in particular subtypes of cancer.

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