scholarly journals THE ROLE OF METABOLITES IN THE CLINICAL MANIFESTATIONS OF ROSACEA-TIDES (PROBLEMATIC ASPECTS)

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Vyacheslav Hladchuk ◽  
Veronika Bocharova ◽  
Vasily Bocharov
Keyword(s):  
Key Words ◽  
Steroid Hormones ◽  
Sex Hormones ◽  
Clinical Manifestations ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Key Words Fever ◽  
The Brain

The materials consider the problematic aspects of the importance of metabolites in such manifestations of rosacea-tides as local fever and redness of the skin. It is emphasized that in addition to sex steroid hormones, such centers of the brain as thermoregulation and hemodynamics are affected by both hormonal metabolites (sex hormones) and non-hormonal (prostaglandins).Key words: fever and flushing, prostaglandins, steroid metabolites.

Atherosclerosis and sex hormones: current concepts

2010 ◽  
Vol 119 (12) ◽  
pp. 493-513 ◽  
Author(s):  
Amparo C. Villablanca ◽  
Muthuvel Jayachandran ◽  
Carole Banka
Keyword(s):  
Hormone Therapy ◽  
Steroid Hormones ◽  
Sex Hormones ◽  
Vessel Wall ◽  
Molecular Mechanisms ◽  
Disease Risk ◽  
Sex Steroid Hormones ◽  
Metabolic Effects ◽  
Sex Steroid

CVD (cardiovascular disease) is the leading cause of death for women. Considerable progress has been made in both our understanding of the complexities governing menopausal hormone therapy and our understanding of the cellular and molecular mechanisms underlying hormone and hormone receptor function. Understanding the interplay of atherosclerosis and sex steroid hormones and their cognate receptors at the level of the vessel wall has important ramifications for clinical practice. In the present review, we discuss the epidemiology of CVD in men and women, the clinical impact of sex hormones on CVD, and summarize our current understanding of the pathogenesis of atherosclerosis with a focus on gender differences in CVD, its clinical presentation and course, and pathobiology. The critical animal and human data that pertain to the role of oestrogens, androgens and progestins on the vessel wall is also reviewed, with particular attention to the actions of sex hormones on each of the three key cell types involved in atherogenesis: the endothelium, smooth muscle cells and macrophages. Where relevant, the systemic (metabolic) effects of sex hormones that influence atherogenesis, such as those involving vascular reactivity, inflammation and lipoprotein metabolism, are discussed. In addition, four key current concepts in the field are explored: (i) total hormone exposure time and coronary heart disease risk; (ii) the importance of tissue specificity of sex steroid hormones, critical timing and the stage of atherosclerosis in hormone action; (iii) biomarkers for atherosclerosis with regard to hormone therapy; and (iv) the complex role of sex steroids in inflammation. Future studies in this field will contribute to guiding clinical treatment recommendations for women and help define research priorities.

scholarly journals The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility

2011 ◽  
Vol 17 (3) ◽  
pp. 347-361 ◽  
Author(s):  
T. Karasu ◽  
T. H. Marczylo ◽  
M. Maccarrone ◽  
J. C. Konje
Keyword(s):  
Steroid Hormones ◽  
Endocannabinoid System ◽  
Sex Steroid Hormones ◽  
Female Fertility ◽  
Sex Steroid

scholarly journals Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions

2021 ◽  
Vol 11 ◽  
Author(s):  
Pilar Cornejo Ulloa ◽  
Bastiaan P. Krom ◽  
Monique H. van der Veen
Keyword(s):  
Oral Cavity ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Oral Microbiome ◽  
Host Cells ◽  
Sex Steroid ◽  
Hormonal Changes ◽  
Host Microbe Interactions ◽  
Oral Microorganisms

Sex steroid hormones (SSH) are cholesterol-derived molecules. They are secreted into saliva and enter the oral cavity, triggering physiological responses from oral tissues, with possible clinical implications, such as gingival inflammation and bleeding. SSH and hormonal changes affect not only oral host cells but also oral microorganisms.Historically, most research has focused on the effect of hormonal changes on specific bacteria and yeasts. Recently a broader effect of SSH on oral microorganisms was suggested. In order to assess the role of SSH in host-microbe interactions in the oral cavity, this review focuses on how and up to what extent SSH can influence the composition and behavior of the oral microbiome. The available literature was reviewed and a comprehensive hypothesis about the role of SSH in host-microbiome interactions is presented. The limited research available indicates that SSH may influence the balance between the host and its microbes in the oral cavity.

scholarly journals Selected Sex Related Differences in Pathophysiology of Cardiovascular System

2020 ◽  
pp. 21-31 ◽  
Author(s):  
O. KITTNAR
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Steroid Hormones ◽  
Sex Hormones ◽  
Peripheral Resistance ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Plasma Norepinephrine ◽  
Arterial Blood

The annual incidence of cardiovascular diseases is age-dependently increasing both in men and women, however, the prevalence is higher in men until midlife. The higher incidence of cardiovascular disease in men than in women of similar age, and the menopause-associated increase in cardiovascular disease in women, has led to speculation that gender-related differences in sex hormones might have a key role in the development and evolution of cardiovascular disease. There are several suggested pathways in which gender and sex hormones can affect human cardiovascular system to produce original sexually different pathophysiology between women and men. Sex steroid hormones and their receptors are critical determinants of cardiovascular gender differences. Also arterial blood pressure is typically lower in women than in men what could be explained particularly by greater synthesis of nitric oxide (NO) in women. Female cardiomyocytes have a greater survival advantage when challenged with oxidative stress, suggesting that female hormones may play an important role in antioxidative protection of myocardium. It was also demonstrated in animal models that combination of XX chromosomes versus an XY chromosomes enhances sex differences in higher HDL cholesterol. Women were found to have reduced sympathetic activity (reflected by lower total peripheral resistance) and pulmonary artery pressure and enhanced parasympathetic activity relative to men. Similarly, men were found to have higher plasma norepinephrine levels than women. Regarding differences between the sexes in electrophysiology of the heart, two principle mechanisms have been proposed to explain them: hormonal effects on the expression or function of ion channels or, conversely, differences in autonomic tone. To improve diagnosis and treatment of cardiovascular diseases, greater focus on understanding the molecular and cellular physiology of the sex steroid hormones and their receptors in the cardiovascular system will be required.

Role of sex steroid hormones in relative refractoriness to angiotensin II during pregnancy

1984 ◽  
Vol 149 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Tsuneo Tamai ◽  
Shumpei Matsuura ◽  
Nobuya Tatsumi ◽  
Takaaki Nunotani ◽  
Norimasa Sagawa
Keyword(s):  
Angiotensin Ii ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid
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