BIOENERGY ASPECTS OF FUNCTIONING OF VENOUS WALL COMPONENTS (DEMONSTRATION MATERIALS OF STUDENTS AND YOUNG SCIENTISTS)

The subject of the study – the wall of the venous vessels of the skin. The purpose of the work is to provide demonstration and text materials of the significance of bioenergetic mechanisms of vascular wall components. The vascular component is an integral part of the pathogenesis of most dermatoses. At the same time, the bioenergetic aspects of cell function and the extracellular matrix of the vascular wall, especially venous ones, are still insufficiently taken into account, as they are the most vulnerable to inflammatory dermatoses.Key words: vascular wall components, demonstration materials.

MICROCIRCULATORY SYSTEM OF THE SKIN (DEMONSTRATION MATERIALS OF STUDENTS AND YOUNG SCIENTISTS)

The subject of research – the structure of the microcirculatory tract of the skin. The purpose of the work is to provide demonstration materials of students and young scientists of the microcirculatory system of the skin. Even in the modern scientific literature there are many contradictions about the relationship of structural components that form the microcirculatory system of the skin, which dictates the need for further research on the relationship of various blood vessels with other components of the so-called microcirculatory system.Key words: microcirculatory system of skin, demonstration materials.

COSMETOLOGICAL ANATOMICAL PATTERNS OF ROSACEA (DEMONSTRATION MATERIALS OF STUDENTS-SCIENTISTS)

The subject of research – anatomical patterns of rosacea. The aim of the work is to analyze the involvement of structural and functional units of the female body in the formation of cosmetic anatomical patterns of rosacea on the basis of demonstration materials selected by students in distance learning. Local tides in women with heat and redness of the facial skin in rosacea are closely associated with a violation of the functional state of innervation in this area of blood vessels, skin appendages, as well as central disorders of sensory perception.Key words: rosacea-tides, facial innervation, thalamus.

THE ROLE OF ENDOGENOUS NEUROPEPTIDES IN THE PATHOGENESIS AND CLINICAL MANIFESTATIONS OF ROSACEA-TIDES IN WOMEN

Rosacea is a common skin disease with a chronic recurrent course. Numerous factors of etiology and pathogenesis of this dermatosis, which may influence the appearance of its clinical signs, have not been elucidated. The aim of the work is to determine the content of endogenous neuropeptides (substance P, leu-enkephalin) in the blood, to find out their role in the development of clinical manifestations of rosacea in women. Materials and methods - 47 women with rosacea were clinically and laboratory examined in whom the levels of substance P and leu-enkephalin in the blood were determined by enzyme-linked immunosorbent assay. Results. Quantitative assessment of the degree of manifestations of clinical signs of local redness of the skin and subsequent symptoms of rosacea (pink acne) in women indicates a complex nature of changes in the skin and reactions of the nervous and endocrine systems. The revealed imbalance in the blood of patients with endogenous neuropeptides with different mechanisms of effector and regulatory action (increase - substance P, decrease - leu-enkephalin) indicates a violation of the mutual compensatory relations of these peptide signaling molecules in different functional systems of the body, and the following symptoms of the disease, which differed in women of reproductive and older age.Conclusions. Imbalance of levels of endogenous neuropeptides with opposite effector and regulatory effects (substance P, leu-enkephalin) may be one of the key pathogenetic factors of the appearance and development of clinical manifestations of rosacea in women given the polypotent mechanisms of action of these biologically active compounds as neurotransmitters and antinociceptive mediators, regulators of emotional and behavioral reactions, pro- and anti-inflammatory factors, coordinators of the hypothalamic-pituitary-gonadal system. Misdiagnosis of such manifestations of the disease as rosacea-tides with «menopausal», «migraine-like» and other types of tides in women dictate the need for a comprehensive examination of such patients.Кey words: rosacea, substance P, ley-enkephalin, women’s.

THE ROLE OF METABOLITES IN THE CLINICAL MANIFESTATIONS OF ROSACEA-TIDES (PROBLEMATIC ASPECTS)

The materials consider the problematic aspects of the importance of metabolites in such manifestations of rosacea-tides as local fever and redness of the skin. It is emphasized that in addition to sex steroid hormones, such centers of the brain as thermoregulation and hemodynamics are affected by both hormonal metabolites (sex hormones) and non-hormonal (prostaglandins).Key words: fever and flushing, prostaglandins, steroid metabolites.

PRINCIPLES OF ANGIOCORRECTIVE THERAPY FOR DERMATOSES (PROBLEM LECTURE)

The subject of the research is the angiocorrective therapy of dermatoses. The goal is to classify methods of influencing the structures of the vascular (venous) wall in the treatment of dermatoses. The treatment of many dermatoses, in the pathogenesis of which vasopathy plays a role, requires an individual approach to the choice of means of angiocorrective therapy. In this case, one should take into account the peculiarities of the pathogenesis of the corresponding skin disease and determine the «target structures» of the vascular (venous) wall, the effects on which will provide the necessary clinical effect.Key words: angiocorrective therapy, structures of the venous wall.

PORPHYRINS AND PHOTODYNAMIC SKIN DAMAGE (PROBLEM LECTURE)

The lecture contains materials on the role of porphyrins in the photosensitizing effect on skin structures, which can play a large role in pathophysiological changes in many dermatoses (skin porphyria, lupus erythematosus, rosacea, photodermatitis, and others).Key words: porphyrins, photosensitization, photodermatosis.

ITCHING AND PAIN – ANALOGUES AND DIFFERENCES (PROBLEM LECTURE)

The problematic lecture is devoted to the analogies and differences in the mechanisms of the development of itching and pain both in various dermatoses and in other somatic and psychogenic diseases of a person. Attention is drawn to the fact that certain groups of drugs that are used to treat pain syndromes can also be used to treat chronic itchy skin diseases, which may become a promising area of modern dermatology.Key words: pain, itching, pain relievers.