ABSTRACT Background: The impact of stroke on health may be disastrous. Stroke can affect multiple domains of quality of life. The purpose of this study was to examine biopsychosocial determinants of quality of life in post stroke patients. Subjects and Method: A cross sectional study was conducted at Surakarta hospital, Central Java, from September to October 2019. A sample of 200 post stroke patients was selected for this study purposively. The dependent variable was quality of life. The independent variables were age, gender, empoyment, income, family income, marital status, history of stroke attack, co-morbidity, duration of illness, functional disorder, depression, and family support. The data were collected by medical record and questionnaire. The data were analyzed by a multiple logistic regression. Results: Quality of life of post stroke patients increased with married (b= 1.79; 95% CI= 0.24 to 3.35; p= 0.024), employed (b= 1.93; 95% CI= 0.13 to 3.72; p= 0.035), mild fuctional disorder (b=1.68; 95% CI= 0.11 to 3.25; p= 0.036), and strong family support (b= 2.17; 95% CI= 0.46 to 3.88; p= 0.013). Quality of life of post stroke patients decreased with age ≥60 years (b= -1.99; 95% CI= -3.80 to -0.17; p= 0.032), female (b= -1.74; 95% CI= -3.28 to -0.19; p= 0.027), stroke attack >1 time (b= -1.87; 95% CI= -3.59 to -0.15; p= 0.033), length of illness ≥6 months (b= -2.12; 95% CI= -3.87 to -0.36; p= 0.018), co-morbidity (b= -1.96; 95% CI= -3.67 to -0.24; p= 0.025), and depression (b= -1.40; 95% CI= -2.97 to 0.16; p= 0.078). Conclusion: Quality of life of post stroke patients increases with married, employed, mild fuctional disorder, and strong family support. Quality of life of post stroke patients decreases with age ≥60 years, female, stroke attack >1 time, length of illness ≥6 months, co-morbidity, and depression. Keywords: stroke, quality of life, depression, functional disorder Correspondence: Maki Zamzam. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +6281251543935 DOI: https://doi.org/10.26911/the7thicph.01.35