Combination of Multiple Non-Linearities in Structural Modelling, Simulation and Assessment Work

2010 ◽  
Vol 97 (27) ◽  
pp. 1-8
Author(s):  
Helmut Wenzel
Keyword(s):  
Structural Modelling ◽  
Modelling Simulation

STRUCTURAL MODELLING OF REVERSIBLE PHOTODARKENING IN a-AsxSe

1981 ◽  
Vol 42 (C4) ◽  
pp. C4-391-C4-394 ◽  
Author(s):  
R. Grigorovici ◽  
A. Vancu
Keyword(s):  
Structural Modelling

scholarly journals Consumer Ethicality Perception and Legitimacy: Competitive Advantages in COVID-19 Crisis

2021 ◽  
pp. 000276422110165
Author(s):  
Gregory Payne ◽  
Alicia Blanco-González ◽  
Giorgia Miotto ◽  
Cristina del-Castillo
Keyword(s):  
New York ◽  
Data Collection ◽  
Purchase Intention ◽  
Brand Management ◽  
Mediation Effect ◽  
Competitive Advantages ◽  
Structural Modelling ◽  
Multigroup Analysis ◽  
Ethical Behaviors ◽  
Brand Meaning

The article aims to analyze the cause–effect relationship between Brand Ethicality Perception (CPE), legitimacy and purchase intention during the COVID-19 first wave, taking into consideration the mediation effect of the country of residence. Data collection was based on a survey launched during the COVID-19 lockdown in Madrid and New York. To analyze the established hypotheses and to test the multigroup analysis, we applied a structural modelling with SmartPLS. The research contributes to the field of brand management, and specifically of ethical branding, since it will analyze how stakeholders’ expectations fulfillment is key to build a consistent and valued brand meaning in crisis’ situations, demonstrating that ethical behaviors are key for gaining corporate legitimacy and, therefore, for improving business performances.

scholarly journals Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4718
Author(s):  
Lamya H. Al-Wahaibi ◽  
Bahaa G. M. Youssif ◽  
Ehab S. Taher ◽  
Ahmed H. Abdelazeem ◽  
Antar A. Abdelhamid ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Selectivity Ratio ◽  
Computational Studies ◽  
Design Synthesis ◽  
Ca Ix ◽  
Side Pocket ◽  
Modelling Simulation ◽  
Good Agreement

A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA IX inhibitors with the order of 5g > 5b > 5d > 5e > 5g > 5n (Ki = 0.3–1.3 μM, and selectivity ratio for hCA IX over hCA XII = 5–12) relative to acetazolamide (Ki = 0.03 μM, and selectivity ratio for hCA IX over hCA XII = 0.20). The previous sixth inhibitors have been further investigated for their anti-proliferative activity against four different cancer cell lines using MTT assay. Compounds 5g and 5b demonstrated higher antiproliferative activity than other tested compounds (with GI50 = 2.3 and 2.8 M, respectively) in comparison to doxorubicin (GI50 = 1.1 M). Docking studies of these two compounds adopted orientation and binding interactions with a higher liability to enter the active side pocket CA-IX selectively similar to that of ligand 9FK. Molecular modelling simulation showed good agreement with the acquired biological evaluation.

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