Occurrence site of canine oral lesions: a retrospective study of 659 cases

Many types of tumorous and tumour-like lesions occur in the oral cavity of dogs. Even benign neoplasia often represents great inconvenience due to potential restrictions of therapeutic surgical approach in this area. Whereas in human medicine, there are statistical data describing areas of the oral cavity, that are more prevalent for development of particular neoplasia, in veterinary medicine, these data are not yet available. The aim of this study was to evaluate the prevalence of tumours in dogs with oral neoplasia, the occurrence site of the most common neoplastic lesions in the canine oral cavity, as well as the effect of age and sex on the prevalence of these lesions. In this study we investigated oral tumorous lesions from 659 dogs, out of which 352 lesions were diagnosed as tumours and 307 as tumour-like lesions. The most common tumours encountered were melanoma (42%, n = 148), squamous cell carcinoma (16%, n = 57) and canine acanthomatous ameloblastoma (10%, n = 35). The median age of dogs with oral neoplasia was 9.9 years, with the range of 0.2 to 17.5 years. There was no significant association between sex and the type of oral lesion (tumorous and tumour-like). Melanoma was most commonly present in the caudal maxillary region, squamous cell carcinoma on the mouth floor, canine acanthomatous ameloblastoma in the area of the rostral mandible, plasmacytoma on the tongue, osteosarcoma was most often diagnosed in the caudal parts of oral cavity and fibrosarcoma did not have a specific site of occurrence.

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CLINICOPATHOLOGICAL STUDY OF ORAL LESIONS IN A TERTIARY CARE HOSPITAL

10.36106/gjra/7500641 ◽

2021 ◽

pp. 17-20

Author(s):

Sravani Ponnada ◽

Lakshmi Latchupatula ◽

Tadikonda Krishna Srivathsav ◽

Bhagyalakshmi Atla

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oral Lesion ◽

Oral Lesions ◽

Care Hospital ◽

Common Site ◽

Female Ratio

Background: Oral cavity is a common site for various non-neoplastic and neoplastic lesions. Majority of lesions were neoplastic. Tobacco chewing, smoking and alcohol consumption were the common risk factors implicated in the etiology of malignant oral lesions. Squamous cell carcinoma was the most common lesion of the oral cavity. Aims&Objectives: To study the clinicopathological lesions of the oral cavity with respect to age, gender, location, clinical presentation, histopathological patterns and various risk factors. Materials And Methods: A retrospective study of 274 oral cavity lesions conducted for period of 2 years from January 2019 to December 2020 in the department of pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh. Results: In our study, the age range of the patients was from 3 years to 87 years. Majority of cases were seen in age group of 41- 50 years. Males were more commonly affected than females with a male to female ratio of 2.51:1. Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Tongue was the most common site involved in oral lesions. Mucocele was the commonest non-neoplastic lesion and squamous papilloma was the most common benign lesion. Leucoplakia was the most common premalignant lesion and Squamous cell carcinoma was the commonest malignant lesion. Conclusion: Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Early and accurate identication of potentially malignant oral lesions is important and essential for prevention of morbidity, mortality and for proper treatment of cases. Along with clinical examination and laboratory investigations, histopathological examination is still the gold standard to establish a denitive diagnosis and for conrmation of the nature and origin of oral lesions.

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Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1141 ◽

2013 ◽

Vol 4 (2) ◽

pp. 61-65 ◽

Cited By ~ 3

Author(s):

SC Sharma ◽

Veena Maheshwari ◽

Varsha Narula ◽

Sachin Verma ◽

Anshu Jain ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Premalignant Lesions ◽

Oral Lesions ◽

Older Individuals ◽

Ki 67 ◽

Long Time ◽

Clinicopathological Profile

ABSTRACT Introduction Oral squamous cell carcinoma, the fifth most common cancer worldwide, is a major cause of morbidity and mortality in India. It most commonly occurs in middle-aged and older individuals. Typically, they tend to be preceded by a premalignant state for a long time. The present study evaluates the clinicopathological profile of patients with oral lesions and the role of malpractices that promote carcinogenesis in the oral mucosa and the use of Ki-67 as an important predictor of the same. Materials and methods The expression of Ki-67 was studied in paraffin-embedded tissue sections of oral lesions of all the cases after taking a detailed history and examination. Results The study was conducted on 65 patients with 25 dysplastic and 40 malignant lesions. Males were affected more frequently than females. The most common age group affected was 31 to 60 years with mean age of 45.4 years. Anterior twothird of tongue (41%) was the most commonly affected site. 95% of the patients had a history of addiction in form of smoking, tobacco chewing and betel nut. Out of 25 cases of dysplasia, 11 showed low expression while out of 40 cases of squamous cell carcinoma only three showed low and 29 showed high expression of Ki-67. Conclusion The expression of Ki-67 correlates well with the disease progression from dysplasia to carcinoma of the oral cavity. It is therefore a marker of malignant transformation and carcinogenesis in oral premalignant lesions and in future it may serve as a prognostic tool in the early detection of malignancy. How to cite this article Maheshwari V, Sharma SC, Narula V, Verma S, Jain A, Alam K. Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity. Int J Head Neck Surg 2013;4(2):61-65.

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Feline Oral Neoplasia: A Ten-Year Survey

Veterinary Pathology ◽

10.1177/030098588902600204 ◽

1989 ◽

Vol 26 (2) ◽

pp. 121-128 ◽

Cited By ~ 135

Author(s):

K. E. Stebbins ◽

C. C. Morse ◽

M. H. Goldschmidt

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Periodontal Ligament ◽

Histological Study ◽

Survey Period ◽

Oral Neoplasms ◽

Oral Neoplasia

A retrospective histological study was conducted on 371 neoplasms of the oral cavity in cats. Oral neoplasia accounted for 10% of feline neoplasms identified during the survey period. Eighty-nine percent of the oral neoplasms were malignant. Twenty different oral neoplasms were found. The most common were squamous cell carcinoma (61.2%), fibrosarcoma (12.9%), and fibromatous epulis of periodontal ligament origin (7.8%).

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STUDY OF HISTOPATHOLOGICAL SPECTRUM OF ORAL LESIONS IN TERTIARY CARE HOSPITAL, CIMS (5 YEARS RETROSPECTIVE)

10.36106/1900542 ◽

2021 ◽

pp. 15-17

Author(s):

Shahnaz Bano ◽

Rashmi Gupta ◽

Jyoti Porte ◽

B. P. Singh

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Lesion ◽

Psychological Trauma ◽

Oral Lesion ◽

Care Hospital ◽

Common Site ◽

Neoplastic Lesions

Background: Oral cavity is a common site for non-neoplastic and neoplastic lesions, most are asymptomatic, but lesion like squamous cell carcinoma leads to cosmetic disgurement and mental trauma to the patient. Early diagnosis of premalignant and malignant lesion improves the accuracy of diagnosis and early management. Aim: To study Histopathological Spectrum of Oral cavity Lesions on the basis of type, age, sex and site distribution. Material and methods: A retrospective study was carried out in a pathology department of Chhattisgarh Institute of Medical Sciences (CIMS), Bilaspur, (C.G.) for oral lesion during the time period of Jan 2016 to Dec 2020. Study includes total 275 cases, 650 blocks and 720 stained histopathology slides ( H and E stained). Data like age, sex, site of lesion was collected from histopathological register. Result: Total 275 cases of oral cavity lesions were studied in which were 188 (68.36%) male and 87 (31.64%) were female. Included age group from 6 years to 85 years, out of 275 cases 162 (58.91%) Malignant lesions, 64 (23.27%) non-neoplastic lesions, 31 (11.27%) Benign lesions, 18 (06.55%) premalignant lesions. Buccal mucosa was most common site for oral lesion followed by tongue and lips. Most common lesion was squamous cell carcinoma followed by pyogenic granuloma and inammatory lesions. Conclusion: In our study squamous cell carcinoma is most common malignant lesion of oral cavity . Clinical diagnosis is not enough for determination of the nature of lesion. Histopathological evaluation is important tool for diagnosis of the lesion in premalignant and early stages so we can prevent mental and psychological trauma to the patient

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Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i02/14 ◽

2018 ◽

Vol 3 (02) ◽

Author(s):

Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Cell Population ◽

Squamous Cell ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Biphasic Tumor ◽

Carcinoma Of The Tongue ◽

Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

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PD-L1 and survival in oral cavity squamous cell carcinoma

Periodontology ◽

10.33925/1683-3759-2020-25-4-287-294 ◽

2020 ◽

Vol 25 (4) ◽

pp. 287-294

Author(s):

S. I. Kutukova ◽

N. P. Beliak ◽

G. A. Raskin ◽

M. S. Mukhina ◽

Yu. V. Ivaskova ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Tumor Cells ◽

Squamous Cell ◽

Immune Cells ◽

Negative Impact ◽

Progression Free Survival ◽

Negative Effect ◽

Effect Of Pd

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

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The Length of Peri-Neural Spreading in Clinically Mandibular Invaded Oral Cavity Squamous Cell Carcinoma

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.05. ◽

2020 ◽

pp. 459-464

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymphovascular Invasion ◽

Perineural Invasion ◽

Inferior Alveolar Nerve ◽

Surgical Margin ◽

Neural Invasion ◽

Resected Margin

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy

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