STUDY OF HISTOPATHOLOGICAL SPECTRUM OF ORAL LESIONS IN TERTIARY CARE HOSPITAL, CIMS (5 YEARS RETROSPECTIVE)

Background: Oral cavity is a common site for non-neoplastic and neoplastic lesions, most are asymptomatic, but lesion like squamous cell carcinoma leads to cosmetic disgurement and mental trauma to the patient. Early diagnosis of premalignant and malignant lesion improves the accuracy of diagnosis and early management. Aim: To study Histopathological Spectrum of Oral cavity Lesions on the basis of type, age, sex and site distribution. Material and methods: A retrospective study was carried out in a pathology department of Chhattisgarh Institute of Medical Sciences (CIMS), Bilaspur, (C.G.) for oral lesion during the time period of Jan 2016 to Dec 2020. Study includes total 275 cases, 650 blocks and 720 stained histopathology slides ( H and E stained). Data like age, sex, site of lesion was collected from histopathological register. Result: Total 275 cases of oral cavity lesions were studied in which were 188 (68.36%) male and 87 (31.64%) were female. Included age group from 6 years to 85 years, out of 275 cases 162 (58.91%) Malignant lesions, 64 (23.27%) non-neoplastic lesions, 31 (11.27%) Benign lesions, 18 (06.55%) premalignant lesions. Buccal mucosa was most common site for oral lesion followed by tongue and lips. Most common lesion was squamous cell carcinoma followed by pyogenic granuloma and inammatory lesions. Conclusion: In our study squamous cell carcinoma is most common malignant lesion of oral cavity . Clinical diagnosis is not enough for determination of the nature of lesion. Histopathological evaluation is important tool for diagnosis of the lesion in premalignant and early stages so we can prevent mental and psychological trauma to the patient

Download Full-text

CLINICOPATHOLOGICAL STUDY OF ORAL LESIONS IN A TERTIARY CARE HOSPITAL

10.36106/gjra/7500641 ◽

2021 ◽

pp. 17-20

Author(s):

Sravani Ponnada ◽

Lakshmi Latchupatula ◽

Tadikonda Krishna Srivathsav ◽

Bhagyalakshmi Atla

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oral Lesion ◽

Oral Lesions ◽

Care Hospital ◽

Common Site ◽

Female Ratio

Background: Oral cavity is a common site for various non-neoplastic and neoplastic lesions. Majority of lesions were neoplastic. Tobacco chewing, smoking and alcohol consumption were the common risk factors implicated in the etiology of malignant oral lesions. Squamous cell carcinoma was the most common lesion of the oral cavity. Aims&Objectives: To study the clinicopathological lesions of the oral cavity with respect to age, gender, location, clinical presentation, histopathological patterns and various risk factors. Materials And Methods: A retrospective study of 274 oral cavity lesions conducted for period of 2 years from January 2019 to December 2020 in the department of pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh. Results: In our study, the age range of the patients was from 3 years to 87 years. Majority of cases were seen in age group of 41- 50 years. Males were more commonly affected than females with a male to female ratio of 2.51:1. Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Tongue was the most common site involved in oral lesions. Mucocele was the commonest non-neoplastic lesion and squamous papilloma was the most common benign lesion. Leucoplakia was the most common premalignant lesion and Squamous cell carcinoma was the commonest malignant lesion. Conclusion: Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Early and accurate identication of potentially malignant oral lesions is important and essential for prevention of morbidity, mortality and for proper treatment of cases. Along with clinical examination and laboratory investigations, histopathological examination is still the gold standard to establish a denitive diagnosis and for conrmation of the nature and origin of oral lesions.

Download Full-text

5-year experience with vulval lesions in a tertiary care hospital: series of 115 cases

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20205237 ◽

2020 ◽

Vol 9 (12) ◽

pp. 5001

Author(s):

Ritu Bhat ◽

Sachin Kolte

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tertiary Care ◽

Care Hospital ◽

Labia Minora ◽

Number Of Patients ◽

Rare Tumours ◽

Wide Range ◽

Neoplastic Lesions

Background: Wide range of vulval lesions have been described with similar modes of presentation. Benign and inflammatory lesions form the major chunk. Squamous cell carcinoma is the most reported malignant entity. Aim was to review the vulval lesions received in our departmentMethods: We studied the data from the archives of the Department of Pathology for a period of 5 years from January 2014 to December 2018 for vulval biopsies and specimens sent for histopathological examination. The final diagnoses were divided into non-neoplastic, neoplastic and non- specific.Results: Age of women ranged from 22 to 86 years (mean 54.3±3.6) with the maximum number of patients between 50 to 60 years of age. Most common form of clinical presentation was an itchy white elevated lesion on the vulva (72 cases, 62.6%). The most common site for the lesions was labia minora (90 cases, 78.2%). Non neoplastic lesions were seen in 53 cases and neoplastic lesions were seen in 52 cases. There were 28 (53.8%) benign lesions while 24 cases (46.1%) were malignant. Squamous cell carcinoma was the most frequently diagnosed form accounting for 20 cases (83.3%). Rare tumours like Malignant melanoma, Merkel cell carcinoma and Neuroendocrine carcinoma formed 16.6% (n=4). Seven cases were premalignant. Two cases had non-specific histologic diagnosis showing mild chronic inflammation.Conclusions: Previous studies have reported that non-neoplastic lesions form around 70% of cases. However, in our study we found that the non-neoplastic and neoplastic lesions form equal number of cases (46%) which may be attributed to increased awareness or geographical variation.

Download Full-text

Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i22a31388 ◽

2021 ◽

pp. 53-62

Author(s):

R. Vijay David Raj ◽

S. Marylilly

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Lesion ◽

Malignant Neoplasm ◽

Premalignant Lesions ◽

Group I ◽

Malignant Lesions

Squamous cell carcinoma is the summits malignant neoplasm of the oral cavity. Tobacco and alcohol is identified as risk factors, but squamous cell carcinoma can occur in patients with no known risk factors. Oral cancer is the sixth most common malignancy and is one of the major causes of cancer morbidity and mortality worldwide. Cancer is caused due to a series of alteration in genetic and epigenetic factors that occur in multiple steps and is influenced by the genetic predisposition of the individual and by exogenous environmental factors. These factors result in a series of molecular alteration, including inactivation of tumor suppressor genes expression of p16 has been proposed as a marker for malignant transformation. The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer’s exact test. This study concluded that p16 was increasingly expressed in premalignant lesions and less expressed in malignant lesion. In the present study 9 of the control cases were p16 negative and one case showed sporadic staining. The study group I showed 1 case of sporadic staining, 6 cases of focal staining and 8 cases of diffuse staining. The study II showed 14 cases of sporadic staining, 6 cases of focal staining and 5 cases of diffuse staining. Hence variations cannot be accurately assessed, but it plays a crucial role in assessing pre-malignant lesions progressing to malignancy. To confirm this, a larger sample study is required. As advances in research have leads to greater understanding of potentially malignant lesions in the oral cavity.

Download Full-text

Clinico-Histological presentation of Head and Neck Lesions in a Tertiary Care Hospital

Journal of Rawalpindi Medical College ◽

10.37939/jrmc.v25i1.1327 ◽

2021 ◽

Vol 25 (1) ◽

pp. 21-25

Author(s):

Mohammad Sajjad Kattak ◽

Abdul Ghafoor ◽

Rafi Ullah ◽

Asif Mehmmod ◽

Mohammad Iqbal ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Basal Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Basal Cell ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Malignant Lesions

Objective: This study aimed to see the clinical presentation and histological pattern of various head and neck lesions.Materials and Methods: This descriptive study was conducted in the Department of Pathology, Bannu Medical College in association with the Department of Surgery and ENT, Khalifa Gul Nawaz Teaching Hospital, Bannu. A total of 184 cases of head and neck lesions biopsy were subjected to histopathological diagnosis. Patients' age, gender, anatomical location, and other relevant necessary clinical findings were recorded on an already designed proforma. All biopsies were received in 10% buffered formalin, fixed overnight, and processed for histopathological examination and diagnosis. Inclusion criteria were patients with head and neck lesions including skin, salivary gland, lymph node, and oral cavity of any age and gender. Exclusion criteria were thyroid, nasal cavity lesions, autolysed, and insufficient biopsy specimen. Results: In this study, the mean age was 28.58 ± 17.34 years, and the age range was from 10 to 80 years. The male-to-female ratio was 1.3:1. The most common age group was 36-45 years followed by 46-55 years and 26-35 years etc. The most common inflammatory lesion was granulomatous lymphadenitis 14.67% followed by reactive lymphoid hyperplasia 9.23%. Common benign lesions were pleomorphic adenoma 5.97% followed by lipoma and hemangioma 3.80% and 3.26% respectively. Amongst malignant lesions basal cell carcinoma 23.91% of the face was the commonest lesion followed by squamous cell carcinoma 22.28% of the oral cavity. Conclusion: This study show spectrum of lesions from inflammatory to benign and malignant, occurring in the head and neck region. Malignant lesions are more common as compared to benign and inflammatory lesions, basal cell carcinoma of the skin is the commonest malignant lesion followed by squamous cell carcinoma of the skin and oral cavity.

Download Full-text

Clinico-pathological Spectrum of Oral Cavity Lesions at a Tertiary Care Center in Central Nepal: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association ◽

10.31729/jnma.5539 ◽

2021 ◽

Vol 59 (234) ◽

Author(s):

Shankar Bastakoti ◽

Gambhir Shrestha ◽

Dej Kumar Gautam ◽

Ishan Dhungana ◽

Nandita Jha ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tertiary Care ◽

Malignant Lesion ◽

Female Ratio ◽

Central Nepal ◽

Common Cancer ◽

Malignant Lesions

Introduction: Head and neck cancer is the sixth most common cancer in the world. The disease burden is increasing at an alarming rate in developing Southeast Asian countries. This study aims to report the histopathological spectrum of oral cavity lesions at a tertiary cancer center in central Nepal. Methods: This study included all those cases of oral cavity lesions, of which diagnostic biopsy was done from January 2018 to December 2019. The data were retrieved from the Department of Pathology of BP Koirala Memorial Cancer Hospital. The study proposal was approved by the Institutional Review Committee at BPKMCH (Ref: 247/2020) on 28th June 2020. Results: A total of 851 cases of oral cavity lesions were included in this study. The mean age of the study population was 55.9 years, with male to female ratio of 3:1. Malignant lesions composed of 472 (55.5%) cases followed by premalignant lesion of 104 (12%). More than 453 (95%) malignant cases were squamous cell carcinoma, of which 342 (75%) were a well-differentiated type. The buccal cavity is the most common site of malignant lesion 212 (45%), followed by tongue 96 (20%) and lower gingivobuccal region 86 (18%). Conclusions: Malignant lesions are the most common histopathological fi ndings in the oral cavity lesion with squamous cell carcinoma type. Oral cancer is common cancer that can be prevented and cured if detected early.

Download Full-text

A Histopathological Study of Neoplastic Lesions of Conjunctiva

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v4i1.19077 ◽

2018 ◽

Vol 4 (1) ◽

pp. 32-35

Author(s):

Urvashi Gupta ◽

Ruchi Shrestha ◽

Ashok P Samdurkar ◽

Anita Shahi

Keyword(s):

Squamous Cell Carcinoma ◽

Malignant Melanoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Benign Lesion ◽

Medical Science ◽

Malignant Lesion ◽

Histopathological Study ◽

Squamous Papilloma ◽

Neoplastic Lesions

BACKGROUND: Ocular malignant tumors are relatively rare compared to other eye lesions, require immediate diagnosis and management. But ignorant care due to unawareness of persons can result into debility, loss of vision, and occasionally life is jeopardized.1 The aim of the study is to determine the frequency of most common neoplastc lesions of conjunctiva with histopathologically confirmed diagnosis. MATERIAL AND METHODS: It was a retrospective cross-sectional study done in a period of two years (January 2011 December 2012) that included120 patients who presented with conjunctival lesions to the pathology department of Universal College of Medical Science, Bhairahawa, Nepal. RESULTS: In this study out of 120 biopsies which were histopathologically diagnosed as conjunctival neoplasms were categorized into benign, dysplastic and malignant lesion and was common after second decade of life. Majority of cases (75 cases, 62.5%) were categorized as benign lesion with predominance of squamous papilloma (n=25) and nevus (n=21), followed by malignant lesion (27 cases, 22.5%) and dysplastic lesions (18 cases, 15%). Amongst malignancies, squamous cell carcinoma (SCC) was the most prevalent and a case of malignant melanoma was studied. Dysplastic lesion included conjunctival intraepithelial neoplasia (CIN) with and without squamous papilloma. CONCLUSION: Histopathology plays an important role in diagnosis of conjunctival lesions and rules out different categories of neoplastic lesions on routine basis. In this study Squamous cell carcinoma (SCC) 20.01% is the most common malignant tumor of conjunctiva. The next majority of cases diagnosed as the verrucuous carcinoma 1.66% and malignant melanoma 0.83% maximum case of malignant cases diagnosed in the age group of more than 50 years. Journal of Universal College of Medical Sciences (2016) Vol.04 No.01 Issue 13, Page: 32-35

Download Full-text

Oral cavity lesions: A study of 21 cases

Journal of Pathology of Nepal ◽

10.3126/jpn.v1i1.4452 ◽

1970 ◽

Vol 1 (1) ◽

pp. 49-51 ◽

Cited By ~ 1

Author(s):

S Pudasaini ◽

R Baral

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Community Hospital ◽

Buccal Cavity ◽

Malignant Lesion ◽

Common Site ◽

Benign Lesions ◽

Inflammatory Conditions ◽

Neoplastic Lesions ◽

Rational Management

Background: Development of lesions in the oral cavity is strongly linked with smoking and alcohol consumption. Non neoplastic lesions are mainly inflammatory conditions. It has been seen that the benign lesions are more common than malignant. Materials and methods: This was a retrospective study carried out in the Department of Histopathology of Helping Hands Community Hospital during a period of one and a half years from January 2009 to June 2010. The study included 21 cases of oral cavity lesions. Results: The most common site was lip with 9 cases (42.8%) followed by buccal cavity with 5 cases (23.8%). Out of the 21 cases of oral cavity lesions, 20 cases (95.2%) were benign and 1 case (4.8%) was malignant. The malignant lesion was a case of squamous cell carcinoma of soft palate. Conclusion: Any oral cavity lesion should have a tissue diagnosis for rational management of the case and to avoid mutilating surgery. Keywords: Oral cavity; Fibroma; Mucocele DOI: 10.3126/jpn.v1i1.4452 Journal of Pathology of Nepal (2011) Vol.1, 49-51

Download Full-text

Profile of oral cavity neoplastic lesions: two year pilot study at tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20202208 ◽

2020 ◽

Vol 6 (6) ◽

pp. 1107

Author(s):

Manish Munjal ◽

Ramandeep Kaur ◽

Porshia Rishi ◽

Nitika Tuli ◽

Harjinder Singh ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Survival Rate ◽

Oral Cavity ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Histopathological Diagnosis ◽

Female Ratio ◽

Neoplastic Lesions

Background: In India 53,251 new head and neck cancer cases are diagnosed every year. Benign tumours are more frequently in the oral cavity than oropharynx.Methods: The prospective study was carried out in the Department of Otolaryngology and Head and Neck Surgery, Dayanand Medical College and Hospital, Ludhiana, over a period of two and half years, comprised of 66 cases of head and neck neoplasia. The demographic, gender profile, clinical presentation, histopathological diagnosis, therapeutic modality undertaken and post op complications of neoplastic lesions of the oral cavity were studied. follow up was done for 6 months. The therapeutic modalities included surgery, radiotherapy and chemotherapy as per the stage of the lesion.Results: Incidence of oral cancer is 13.6% among head and neck neoplasms over a period of 2 years (2011-2012). The overall male to female ratio was 1:1.25, among benign was 1:1 and among malignant was 1:1.3. Benign oral cavity tumors were managed surgically with wide excision. Out of 7, 4 (44%) malignant oral cavity tumor patient experienced difficulty in swallowing. Three (43%) out of 4 squamous cell carcinoma patients complained of difficulty in speaking, which is commonly seen in post-glossectomy patients. The survival rate for 6 months follows up, was 100%.Conclusions: Squamous cell carcinoma is the commonest oral cavity neoplasia. At post treatment follow up period of 6 months survival rate of benign neoplasia is better than malignant neoplasia.

Download Full-text

Occurrence site of canine oral lesions: a retrospective study of 659 cases

Acta Veterinaria Brno ◽

10.2754/avb202089020179 ◽

2020 ◽

Vol 89 (2) ◽

pp. 179-187

Author(s):

Barbora Putnová ◽

Jana Burová ◽

Marilena Georgiou ◽

Tomáš Fichtel ◽

Ladislav Stehlík ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Statistical Data ◽

Oral Lesion ◽

Oral Lesions ◽

Effect Of Age ◽

Maxillary Region ◽

Oral Neoplasia

Many types of tumorous and tumour-like lesions occur in the oral cavity of dogs. Even benign neoplasia often represents great inconvenience due to potential restrictions of therapeutic surgical approach in this area. Whereas in human medicine, there are statistical data describing areas of the oral cavity, that are more prevalent for development of particular neoplasia, in veterinary medicine, these data are not yet available. The aim of this study was to evaluate the prevalence of tumours in dogs with oral neoplasia, the occurrence site of the most common neoplastic lesions in the canine oral cavity, as well as the effect of age and sex on the prevalence of these lesions. In this study we investigated oral tumorous lesions from 659 dogs, out of which 352 lesions were diagnosed as tumours and 307 as tumour-like lesions. The most common tumours encountered were melanoma (42%, n = 148), squamous cell carcinoma (16%, n = 57) and canine acanthomatous ameloblastoma (10%, n = 35). The median age of dogs with oral neoplasia was 9.9 years, with the range of 0.2 to 17.5 years. There was no significant association between sex and the type of oral lesion (tumorous and tumour-like). Melanoma was most commonly present in the caudal maxillary region, squamous cell carcinoma on the mouth floor, canine acanthomatous ameloblastoma in the area of the rostral mandible, plasmacytoma on the tongue, osteosarcoma was most often diagnosed in the caudal parts of oral cavity and fibrosarcoma did not have a specific site of occurrence.

Download Full-text

Prevalence of Histopathologically Diagnosed Ophthalmic Neoplastic Lesion Among Ophthalmic Biopsies in a Pathology Laboratory of Tertiary Hospital of Nepal

Journal of Nepal Medical Association ◽

10.31729/jnma.4635 ◽

2020 ◽

Vol 57 (219) ◽

Author(s):

Santosh Upadhyaya Kafle ◽

Mrinalini Singh ◽

Prerna Arjyal Kafle ◽

BalKumar KC ◽

Sanjeeb Kumar Yadav ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Binary Data ◽

Tertiary Care ◽

Care Hospital ◽

Pathology Laboratory ◽

Medical College ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Introduction: Many vision threatening or life threatening neoplastic conditions often mimic less aggressive neoplastic or non-neoplastic inflammatory variants. This study aims to comprehensively analyze the histopathological spectrum of ophthalmic neoplastic lesions tumors in a pathology laboratory in a tertiary care hospital. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology at Birat Medical College and Teaching Hospital, Morang, Nepal over a period from November 2016 to October 2018. Ethical clearance was taken from Institutional Review Committee of Birat Medical College. Sample size was calculated and convenience sampling was done. Data was collected in excel and analyzed in Statistical Package for Social Sciences version 16. Point estimate at 95% Confidence Interval was calculated and frequency and percentage was calculated for binary data. Subgroup analysis was done based on age, sex, nature of lesions and site of lesions. Results: Prevalence of ophthalmic neoplastic lesion was 139 (55.37%), of which 74 (53.24%) were benign and 65 (46.76%) were malignant. Benign was mostly seen in females and of second decade and malignant was common in males and seventh decade of life respectively. Nevus in 18 (24.3%) and squamous cell carcinoma in 30 (17.6%) was found to be the most common benign and malignant lesions among the specimens. Conjunctiva and cornea in 52 (37.41%) was the most common location for those neoplastic lesions. Conclusions: The most common ophthalmic neoplastic lesion was benign. Nevus is common in females and second decade and squamous cell carcinoma is common in males and seventh decade of life.

Download Full-text