Seroprevalence of Coxiella burnetii antibodies and chronic Q fever among post-mortal and living donors of tissues and cells from 2010 to 2015 in the Netherlands

Background After a large Q fever outbreak in the Netherlands in the period from 2007 to 2010, the risk of Q fever transmission through tissue and cell transplantation from undiagnosed chronic Q fever cases became a potential issue. Aim: We aimed to evaluate the risk of Q fever transmission through tissue and cell transplantation. Methods: We performed a retrospective observational cohort study among 15,133 Dutch donors of tissues and stem cells from 2010 to 2015 to assess seroprevalence of Coxiella burnetii antibodies, to identify factors associated with presence of C. burnetii antibodies, and to assess the proportion of undiagnosed chronic Q fever cases. Results: The study population consisted of 9,478 (63%) femoral head donors, 5,090 (34%) post-mortal tissue donors and 565 (4%) cord blood donors. Seroprevalence of C. burnetii antibodies gradually decreased after the outbreak, from 2.1% in 2010 to 1.4% in 2015, with a significant trend in time (p < 0.001). Of 301 seropositive donors, seven (2.3%) were newly detected with chronic Q fever (0.05% of all screened donors). Conclusion: This study shows that seroprevalence of C. burnetii antibodies among donors of tissues and cells in the Netherlands after 2014 was similar to pre-outbreak levels in the general population. The proportion of newly detected chronic Q fever patients among donors of tissues and cells was smaller than 0.1%. This study may prompt discussion on when to terminate the screening programme for chronic Q fever in donors of tissues and cells in the Netherlands.

Download Full-text

Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands

BMC Infectious Diseases ◽

10.1186/1471-2334-14-6 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 4

Author(s):

Marja J van Wijk ◽

D Willemijn Maas ◽

Nicole HM Renders ◽

Mirjam HA Hermans ◽

Hans L Zaaijer ◽

...

Keyword(s):

The Netherlands ◽

Coxiella Burnetii ◽

Q Fever ◽

Post Mortem ◽

Tissue Donors

Download Full-text

Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak

Epidemiology and Infection ◽

10.1017/s0950268812001203 ◽

2012 ◽

Vol 141 (4) ◽

pp. 847-851 ◽

Cited By ~ 44

Author(s):

L. M. KAMPSCHREUR ◽

J. C. J. P. HAGENAARS ◽

C. C. H. WIELDERS ◽

P. ELSMAN ◽

P. J. LESTRADE ◽

...

Keyword(s):

High Risk ◽

The Netherlands ◽

Confidence Interval ◽

Coxiella Burnetii ◽

Catchment Area ◽

Q Fever ◽

Risk Groups ◽

Chronic Q Fever ◽

Epidemic Area ◽

Acute Q Fever

SUMMARYThe Netherlands experienced an unprecedented outbreak of Q fever between 2007 and 2010. The Jeroen Bosch Hospital (JBH) in 's-Hertogenbosch is located in the centre of the epidemic area. Based on Q fever screening programmes, seroprevalence of IgG phase II antibodies to Coxiella burnetii in the JBH catchment area was 10·7% [785 tested, 84 seropositive, 95% confidence interval (CI) 8·5–12·9]. Seroprevalence appeared not to be influenced by age, gender or area of residence. Extrapolating these data, an estimated 40 600 persons (95% CI 32 200–48 900) in the JBH catchment area have been infected by C. burnetii and are, therefore, potentially at risk for chronic Q fever. This figure by far exceeds the nationwide number of notified symptomatic acute Q fever patients and illustrates the magnitude of the Dutch Q fever outbreak. Clinicians in epidemic Q fever areas should be alert for chronic Q fever, even if no acute Q fever is reported.

Download Full-text

Coxiella burnetii blood cultures from acute and chronic Q-fever patients.

Journal of Clinical Microbiology ◽

10.1128/jcm.33.12.3129-3132.1995 ◽

1995 ◽

Vol 33 (12) ◽

pp. 3129-3132 ◽

Cited By ~ 44

Author(s):

D Musso ◽

D Raoult

Keyword(s):

Coxiella Burnetii ◽

Q Fever ◽

Blood Cultures ◽

Chronic Q Fever

Download Full-text

A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

Clinical Microbiology and Infection ◽

10.1111/1469-0691.12423 ◽

2014 ◽

Vol 20 (7) ◽

pp. 642-650 ◽

Cited By ~ 21

Author(s):

T. Schoffelen ◽

T. Sprong ◽

C.P. Bleeker-Rovers ◽

M.C.A. Wegdam-Blans ◽

A. Ammerdorffer ◽

...

Keyword(s):

Interferon Gamma ◽

Coxiella Burnetii ◽

Q Fever ◽

Interleukin 2 ◽

Circulating Cells ◽

Chronic Q Fever

Download Full-text

Detection of Coxiella burnetii DNA in the environment during and after a large Q fever epidemic in the Netherlands

Journal of Applied Microbiology ◽

10.1111/jam.12163 ◽

2013 ◽

Vol 114 (5) ◽

pp. 1395-1404 ◽

Cited By ~ 21

Author(s):

A. de Bruin ◽

I. Janse ◽

M. Koning ◽

L. de Heer ◽

R.Q.J. van der Plaats ◽

...

Keyword(s):

The Netherlands ◽

Coxiella Burnetii ◽

Q Fever

Download Full-text

Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States

Case Reports in Infectious Diseases ◽

10.1155/2019/5369707 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Zanthia Wiley ◽

Sujan Reddy ◽

Kara M. Jacobs Slifka ◽

David C. Brandon ◽

John Jernigan ◽

...

Keyword(s):

United States ◽

Abdominal Pain ◽

Aortic Aneurysm ◽

Coxiella Burnetii ◽

Q Fever ◽

Antibody Detection ◽

Vascular Involvement ◽

Chronic Q Fever ◽

Aneurysm Repair ◽

Aortic Aneurysm Repair

Q fever is a zoonotic bacterial infection caused by Coxiella burnetii. Chronic Q fever comprises less than five percent of all Q fever cases and, of those, endocarditis is the most common presentation (up to 78% of cases), followed by vascular involvement. Risk factors for chronic Q fever with vascular involvement include previous vascular surgery, preexisting valvular defects, aneurysms, and vascular prostheses. The most common symptoms of chronic Q fever with vascular involvement are nonspecific, including weight loss, fatigue, and abdominal pain. Criteria for diagnosis of chronic Q fever include clinical evidence of infection and laboratory criteria (antibody detection, detection of Coxiella burnetii DNA, or growth in culture). Treatment of chronic Q fever with vascular involvement includes a prolonged course of doxycycline and hydroxychloroquine (≥18 months) as well as early surgical intervention, which has been shown to improve survival. Mortality is high in untreated chronic Q fever. We report a case of chronic Q fever with vascular involvement in a 77-year-old man with prior infrarenal aortic aneurysm repair, who lived near a livestock farm in the southeastern United States.

Download Full-text

Adverse events and association with age, sex and immunological parameters of Q fever vaccination in patients at risk for chronic Q fever in the Netherlands 2011

Vaccine ◽

10.1016/j.vaccine.2014.09.061 ◽

2014 ◽

Vol 32 (49) ◽

pp. 6622-6630 ◽

Cited By ~ 9

Author(s):

Teske Schoffelen ◽

Albert Wong ◽

Hans C. Rümke ◽

Mihai G. Netea ◽

Aura Timen ◽

...

Keyword(s):

At Risk ◽

The Netherlands ◽

Adverse Events ◽

Q Fever ◽

Immunological Parameters ◽

Chronic Q Fever ◽

Patients At Risk

Download Full-text

Animals withCoxiella burnetiiInfection Demonstrate a Western Immunoblot Profile of Chronic Q Fever in Humans

Canadian Journal of Infectious Diseases ◽

10.1155/1996/853518 ◽

1996 ◽

Vol 7 (1) ◽

pp. 45-48

Author(s):

TJ Marrie ◽

Linda Yates

Keyword(s):

Immune Response ◽

Phase I ◽

Phase Ii ◽

Coxiella Burnetii ◽

Q Fever ◽

Western Immunoblotting ◽

Western Immunoblot ◽

Chronic Q Fever

Western immunoblotting was used to compare the immune response toCoxiella burnetiiphase I and phase II antigens of humans with acute and chronic Q fever with that of infected cats, rabbits, cows and raccoons. The cats, rabbits, cows and raccoons had an immunoblot profile similar to that of the human with chronic Q fever.

Download Full-text