Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons
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The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4–10-fold reduced susceptibility to baloxavir.
2016 ◽
Vol 113
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pp. 9033-9038
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2014 ◽
Vol 58
(4)
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pp. 2045-2051
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2008 ◽
Vol 52
(9)
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pp. 3284-3292
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2013 ◽
Vol 57
(12)
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pp. 1703-1712
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2000 ◽
Vol 74
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pp. 8243-8251
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