scholarly journals Inhibition of the biosynthesis of polyketide mycotoxins by microbial metabolites

2020 ◽  
Author(s):  
D. V. Erokhin ◽  
O. D. Mikityuk ◽  
L. A. Shcherbakova ◽  
V. G. Dzhavakhiya
Keyword(s):  
Secondary Metabolite ◽  
Aflatoxin B1 ◽  
Microbial Metabolites

6-Demethylmevinoliin, a secondary metabolite of Penicillum citrinum, is able to efficiently inhibit the biosynthesis of two polypeptide mycotoxins, aflatoxin B1 and zearalenone, by 92 and 78% of the control, respectively.

scholarly journals Mycotoxin degradation by microbial metabolites

2020 ◽  
Author(s):  
N. V. Statsyuk ◽  
L. A. Shcherbakova ◽  
O. D. Mikityuk ◽  
T. A. Nazarova ◽  
V. G. Dzhavakhiya
Keyword(s):  
Aflatoxin B1 ◽  
Gliocladium Roseum ◽  
Microbial Metabolites ◽  
Mycotoxin Degradation ◽  
Extracellular Metabolites ◽  
Optimum Ph ◽  
Enzymatic Nature ◽  
Optimum Ph And Temperature

Extracellular metabolites of Gliocladium roseum GRZ7 are able to destroy aflatoxin B1 and zearalenone (by 61.9 and 68%, respectively). The determined optimum pH and temperature confirm the enzymatic nature of these metabolites.

scholarly journals Detection of aflatoxin producing Aspergillus flavus from animal feed in Karnataka, India.

2021 ◽  
Vol 36 (3) ◽  
pp. e2021017
Author(s):  
Pethannan Rajarajan ◽  
Katherin Sylvia ◽  
Malaiyarasa Pandian Periasamy ◽  
Maheswari Subramanian
Keyword(s):  
Aspergillus Niger ◽  
Secondary Metabolite ◽  
Aspergillus Flavus ◽  
Aflatoxin B1 ◽  
Liquid Ammonia ◽  
Animal Feed ◽  
Average Concentration ◽  
Aflatoxin Contamination ◽  
Ammonia Vapor ◽  
Karnataka State

Aflatoxins are toxic carcinogenic secondary metabolite produced by Aspergillus flavus and are responsible for contamination in animal feed. The aim of the study was to determine the prevalence of aflatoxin contamination in animal feed in Karnataka state, India. The screening was performed by desiccated coconut agar and quantification of aflatoxin by liquid ammonia vapor test, TLC and ELISA. A total of 29 samples received from different places of Karnataka were analysed for aflatoxin B1. Out of 29 animal feed sample aflatoxin B1 detected in 12 samples representing 41.38% at average concentration of 288.50 μg/kg. Out of 42 isolates screened in animal feed, Aspergillus flavus was found to be in 86.2% and Aspergillus niger was 24.1%. It was observed that out of 42 isolates analyzed from animal feed, aflatoxin B1 was detected in 12 samples. Aflatoxin B1 is the most common contaminant and the method is more sensitive in screening and detection of aflatoxin B1 in the animal feed.

Targeting secondary metabolite biosynthetic genes from the metagenome of the sponge Mycale sp

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SA Van der Sar ◽  
KM Fisch ◽  
C Gurgui ◽  
TA Nguyen ◽  
J Piel ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Biosynthetic Genes

Coronilla varia L. nitrotoxins as defensive secondary metabolite against heavy metals pollution

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Noori ◽  
F Amini ◽  
M Foroghi
Keyword(s):  
Heavy Metals ◽  
Secondary Metabolite ◽  
Metals Pollution ◽  
Coronilla Varia ◽  
Heavy Metals Pollution

Prevalence of Aflatoxin B1 and its producing fungi in imported Wheat and Rice to Umm Qasser port (Iraq)

2012 ◽  
Vol 25 (1) ◽  
pp. 161-172
Author(s):  
Kithar Rasheed Majeed
Keyword(s):  
Aflatoxin B1

HISTOLOGICAL CHANGES IN THE INTESTINES OF POULTRY DURING FODDER INTOXICATION

2020 ◽  
Author(s):  
E.P. Dolgov ◽  
◽  
A.A. Abramov ◽  
E.V. Kuzminova ◽  
E.V. Rogaleva ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Examination ◽  
Aflatoxin B1 ◽  
Structural Changes ◽  
Clinical Manifestations ◽  
Feed Additives ◽  
The Body ◽  
Histological Changes ◽  
Beet Pulp

The article presents the data on the study of the influence of mycotoxins combination (T-2 toxin at the concentration of 0.095 mg/kg and aflatoxin B1 in the concentration of 0.019 mg/kg) on the body of quails and the results of pharmacocorrection of toxicosis with a complex consisting of beet pulp and lecithin. Structural changes in the intestines of quais at fodder mycotoxicosis are described. The use of antitoxic feed additives in poultry led to a weakening of the action of xenobiotics, which was confirmed by an increase in the safety of poultry and increase in body weight of quails, a decrease in the clinical manifestations of intoxication, as well as in positive changes in the structure of the intestine of the poultry during histological examination.

The role of aromatic microbial metabolites

2018 ◽  
pp. 97-108
Author(s):  
Н.В. Белобородова ◽  
В.В. Мороз ◽  
А.Ю. Бедова
Keyword(s):  
Process Integration ◽  
Biological Effects ◽  
Clinical Findings ◽  
Multiple Organ ◽  
Critical Conditions ◽  
Clear Understanding ◽  
Microbial Metabolites ◽  
Blood Concentrations

Интеграция метаболизма макроорганизма и его микробиоты, обеспечивающая в норме симбиоз и саногенез, нарушается при заболеваниях, травме, критическом состоянии, и вектор взаимодействия может изменяться в пользу прокариотов по принципу «метаболиты бактерий - против хозяина». Анализ литературы показал, что, с одной стороны, имеется живой интерес к ароматическим микробным метаболитам, с другой - отсутствует четкое представление об их роли в организме человека. Публикации, касающиеся ряда ароматических микробных метаболитов (фенилкарбоновых кислот, ФКК), как правило, не связаны между собой по тематике и направлены на решение тех или иных прикладных задач в разных областях биологии и медицины. Цель обзора - анализ информации о происхождении, биологических эффектах ФКК в экспериментах in vitro и in vivo , и клинических наблюдениях. Обобщая результаты приведенных в обзоре исследований на клеточном, субклеточном и молекулярном уровнях, логично предположить участие ароматических микробных метаболитов в патогенезе полиорганной недостаточности при сепсисе. Наиболее перспективным для раскрытия роли ароматических микробных метаболитов представляется изучение механизмов вторичной почечной недостаточности и септической энцефалопатии. Важным направлением для будущих исследований является изучение влияния продуктов микробной биодеградации ароматических соединений на развитие диссеминированного внутрисосудистого свертывания крови, артериальной гипотензии и септического шока. Результаты дальнейших исследований будут иметь не только фундаментальное значение, но и обогатят практическую медицину новыми диагностическими и лечебными технологиями. Significant increases in blood concentrations of some aromatic metabolites (phenylcarboxylic acids, PhCAs) in patients with sepsis have been previously shown. Enhanced bacterial biodegradation of aromatic compounds has been demonstrated to considerably contribute to this process. Integration of macroorganism metabolism and its microbiota, which provides normal symbiosis and sanogenesis, is disturbed in diseases, trauma, and critical conditions. Direction of this interaction may change in favor of prokaryotes according to the principle, “bacterial metabolites are against the host”. Analysis of literature showed a particular interest of many investigators to aromatic microbial metabolites. However, there is no clear understanding of their role in the human body. Publications on PhCAs are generally not thematically interrelated and usually focus on solving applied tasks in different fields of biology and medicine. The aim of this work was to consolidate existing information about origin and biological effects of PhCAs in in vitro / in vivo experiments and some clinical findings. The presented summary of reported data from studies performed at cellular, sub-cellular, and molecular levels suggests participation of aromatic microbial metabolites in the pathogenesis of multiple organ failure in sepsis. Studying mechanisms of secondary renal failure and septic encephalopathy is most promising for discovering the function of aromatic microbial metabolites. Effects of microbial biodegradation products of aromatic substances on development of disseminated intravascular coagulation, hypotension, and septic shock are an important challenge for future studies. Results of further investigations will be not only fundamental, but will also enrich medical practice with new diagnostic and therapeutic technologies.

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