A Survey of Anti-cancer Properties of Sea Buckthorn

Hippophae rhamnoides L, commonly called Sea buckthorn, is native to Asia and Europe and and known for its nutritional and medicinal values. The aim of the present study was to investigate the anti-cancer constituents of H. rhamnoides. Among the three isolated compounds namely: 1-(2-hydroxynaphthalen-1-yl) ethan-1-one (1), Oleanolic acid (2), and Hippocorosolate (3), compound 3 was a new corosolic ester derivative. The isolated compounds (2 and 3) displayed anticancer activity against lung (NCI-H460) and breast (MCF-7) cancer cell lines with IC50 values of ~3 µM and ~6 µM, respectively. However, compound 1 was active only against breast cancer cells with IC50 value of ~43 µM. These compounds displayed only weak interactions with minor groove of DNA in DNA-ligand conformational studies and therefore, structural DNA damage was not noted in electrophoretic mobility experiments. It was concluded that new compound 2 possessed more potent anticancer activity than that of known compound 3 against lung cancer cell line.

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Sea-buckthorn (Hippophae rhamnoides L.) as a source of compounds with antitumor and radioprotective activity

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0011.7481 ◽

2018 ◽

Vol 72 ◽

pp. 240-252 ◽

Cited By ~ 2

Author(s):

Karolina Ulanowska ◽

Bartosz Skalski ◽

Beata Olas

Keyword(s):

Oxidative Damage ◽

Tumor Cells ◽

Aflatoxin B1 ◽

Blood Circulation ◽

Sea Buckthorn ◽

Malignant Cells ◽

Radioprotective Activity ◽

Bioactive Substances ◽

Lymphoid Leukemia ◽

Anti Cancer

This work presented characteristics of sea buckthorn (H. rhamnoides), the bioactive compounds they contain and their pro-health, anti-cancer and radioprotective activity. Studies have shown that antioxidants contained in the fruits of plant, such as vitamins A, E and phenolic compound, reduce oxidative damage and also inhibit the formation of carcinogenic compounds, such as aflatoxin B1 or N-nitrosamide. Bioactive substances included in sea buckthorn inhibit the growth and proliferation of malignant cells in a variety of systems: digestive, respiratory, reproductive, blood circulation and lymphatic. In addition, experiments conducted on mice and rats demonstrated the effect of sea buckthorn extracts on the apoptosis of the lung, breast, sarcoma, melanoma and lymphoid leukemia tumor cells.

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Rokitnik zwyczajny (Hippophaë rhamnoides L.) w profilaktyce nowotworowej

Postępy Fitoterapii ◽

10.25121/pf.2019.20.2.111 ◽

2019 ◽

Vol 20 (2) ◽

Author(s):

Beata Piłat ◽

Ryszard Zadernowski

Keyword(s):

Cancer Prevention ◽

Nutritional Value ◽

Sea Buckthorn ◽

Hippophae Rhamnoides ◽

Review Of The Literature ◽

Bioactive Substances ◽

Hippophaë Rhamnoides ◽

Anti Cancer ◽

Therapeutic Properties ◽

Hippophae Rhamnoïdes L

The paper describes current research on the use of sea-buckthorn berries in cancer prevention. Sea buckthorn (Hippophaë rhamnoides L.) is a species of leafy shrub widely used throughout the world. The fruits and leaves, from which juices, oils and extracts are produced have the importance of usability. Products obtained from sea-buckthorn have found a recognized nutritional and medical position in many countries. The fruits contain various types of nutrients and bioactive substances: vitamins, carotenoids, flavonoids, polyunsaturated fatty acids, free amino acids and minerals. Clinical and scientific research carried out in the 20th century confirm the nutritional value and therapeutic properties of sea buckthorn, including the most important of them anti-cancer activity. The presented review of the literature is focused on the anti-cancer potential of lipo- and hydrophilic extracts obtained from fruits, seeds and leaves of sea-buckthorn, as well as on the possibilities of their use in anti-cancer prevention.

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