Maternal methyl-enriched diet reduces absence seizures and depression-like comorbidity, and increases DNMT1 and HCN1 gene expression in the somatosensory cortex in adult offspring

2020 ◽  
Author(s):  
Karine Sarkisova ◽  
A. Gabova ◽  
E. Fedosova ◽  
A. Shatskova ◽  
M. Rudenok ◽  
...  
Keyword(s):  
Gene Expression ◽  
Somatosensory Cortex ◽  
Adult Offspring ◽  
Absence Seizures

scholarly journals Maternal Nutrition Induces Pervasive Gene Expression Changes but No Detectable DNA Methylation Differences in the Liver of Adult Offspring

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90335 ◽  
Author(s):  
Matthew V. Cannon ◽  
David A. Buchner ◽  
James Hester ◽  
Hadley Miller ◽  
Ephraim Sehayek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Maternal Nutrition ◽  
Adult Offspring

scholarly journals Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

2020 ◽  
Author(s):  
Vanesa Izquierdo ◽  
Verónica Palomera-Ávalos ◽  
Mercè Pallàs ◽  
Christian Griñán-Ferré
Keyword(s):  
Gene Expression ◽  
Cognitive Decline ◽  
High Fat Diet ◽  
Epigenetic Inheritance ◽  
Adult Offspring ◽  
High Fat ◽  
Molecular Alterations ◽  
Protein Levels ◽  
Age Related ◽  
Inflammatory Profile

Environmental factors as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. The epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol HFD+RV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RV groups and their offspring. Molecularly, a significant increase in 5-mC levels, as well as increased gene expression of Dnmt1 and Dnmt3a in HFD+RV F1 group, were found. Furthermore, a significantly increased of m6A levels in HFD+RV F1 were found, and there were changes in gene expression of its enzymes (Mettl3 and Fto). Moreover, we found a decrease in gene expression levels of pro-inflammatory markers such as Il1-β, Il-6, Tnf-α, Cxcl-10, Mcp-1 and Tgf-β1 in HFD+RV and HFD+RV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Ngf and Nt3 and its receptors TrkA and TrkB. Likewise, an increase in protein levels of BDNF and p-Akt in HFD+RV F1 was found. These results suggest that maternal RV supplementation under HFD intake prevents cognitive decline in SAMP8 adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, restoring the epigenetic landscape as well as synaptic plasticity.

Prenatal dexamethasone exposure in the common marmoset monkey enhances gene expression of antioxidant enzymes in the aorta of adult offspring

Stress ◽  
2009 ◽  
Vol 12 (3) ◽  
pp. 215-224 ◽  
Author(s):  
S. Atanasova ◽  
E. Wieland ◽  
C. Schlumbohm ◽  
M. Korecka ◽  
L. Shaw ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antioxidant Enzymes ◽  
Common Marmoset ◽  
Adult Offspring ◽  
Marmoset Monkey ◽  
The Common

scholarly journals Building Up Absence Seizures in the Somatosensory Cortex: From Network to Cellular Epileptogenic Processes

2017 ◽  
Vol 27 (9) ◽  
pp. 4607-4623 ◽  
Author(s):  
Guillaume Jarre ◽  
Tristan Altwegg-Boussac ◽  
Mark S. Williams ◽  
Florian Studer ◽  
Mathilde Chipaux ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Absence Seizures

No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone

2002 ◽  
Vol 282 (2) ◽  
pp. R343-R350 ◽  
Author(s):  
Miodrag Dodic ◽  
Arianne Peers ◽  
Karen Moritz ◽  
Vicky Hantzis ◽  
E. Marelyn Wintour
Keyword(s):  
Gene Expression ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Hpa Axis ◽  
Receptor Gene ◽  
Adult Offspring ◽  
Significant Difference ◽  
Group D ◽  
Receptor Gene Expression ◽  
Concentration Curves

Exposure of pregnant ewes to dexamethasone, for only 2 days (term ∼150 days) at 27 days of gestation ( group D), results in adult offspring with high blood pressure. In this study, hemorrhage stress has been used to see whether in these animals the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis is altered. In addition, we studied mineralocorticoid (MR) and glucocorticoid (GR) receptor gene expression in the hippocampus and GR gene expression in the hypothalamus using real-time PCR. Calculated areas under the adrenocorticotropin, arginine vasopressin, and cortisol plasma concentration curves in response to hemorrhage were similar between the control and group D. In addition, there was no significant difference in the expression of MR and GR in the hippocampus or GR in the hypothalamus between the control and group D. Taken together, it is unlikely that reset in the HPA axis plays a major role in this particular model of “programmed” hypertension.

scholarly journals Relative Changes in Cerebral Blood Flow and Neuronal Activity in Local Microdomains during Generalized Seizures

2004 ◽  
Vol 24 (9) ◽  
pp. 1057-1068 ◽  
Author(s):  
Hrachya Nersesyan ◽  
Peter Herman ◽  
Ersan Erdogan ◽  
Fahmeed Hyder ◽  
Hal Blumenfeld
Keyword(s):  
Visual Cortex ◽  
Somatosensory Cortex ◽  
Neuronal Activity ◽  
Barrel Cortex ◽  
Similar Distribution ◽  
Somatosensory Stimulation ◽  
Doppler Flowmetry ◽  
Absence Seizures ◽  
Generalized Seizures ◽  
Whisker Stimulation

There is broad agreement that generalized tonic–clonic seizures (GTCS) and normal somatosensory stimulation are associated with increases in regional CBF. However, the data regarding CBF changes during absence seizures are controversial. Electrophysiologic studies in WAG/Rij rats, an established animal model of absence seizures, have shown spike-wave discharges (SWD) that are largest in the perioral somatosensory cortex while sparing the visual cortex. Recent functional magnetic resonance imaging (fMRI) studies in the same model have also shown localized increases in fMRI signals in the perioral somatosensory cortex during SWD. Because fMRI signals are only indirectly related to neuronal activity, the authors directly measured CBF and neuronal activity from specific microdomains of the WAG/Rij cortex using a specially designed probe combining laser-Doppler flowmetry and extracellular microelectrode recordings under fentanyl/haloperidol anesthesia. Using this approach, parallel increases in neuronal activity and CBF were observed during SWD in the whisker somatosensory (barrel) cortex, whereas the visual cortex showed no significant changes. For comparison, these measurements were repeated during somatosensory (whisker) stimulation, and bicuculline-induced GTCS in the same animals. Interestingly, whisker stimulation increased neuronal activity and CBF in the barrel cortex more than during SWD. During GTCS, much larger increases that included both the somatosensory and visual cortex were observed. Thus, SWD in this model produce parallel localized increases in neuronal activity and CBF with similar distribution to somatosensory stimulation, whereas GTCS produce larger and more widespread changes. The normal response to somatosensory stimulation appears to be poised between two abnormal responses produced by two physiologically different types of seizures.

scholarly journals Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model

Epilepsia ◽  
2012 ◽  
Vol 53 (3) ◽  
pp. 477-484 ◽  
Author(s):  
Leena van Raay ◽  
Valentina Jovanovska ◽  
Margaret J. Morris ◽  
Terence J. O’Brien
Keyword(s):  
Neuropeptide Y ◽  
Somatosensory Cortex ◽  
Rat Model ◽  
Absence Seizures
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