MOLECULAR GENETIC MECHANISMS OF ANTIPSYCHOTIC-INDUCED EXTRAPYRAMIDAL DISORDERS IN PATIENTS WITH SCHIZOPHRENIA

AbstractHeterosis has been widely exploited in animal and plant breeding to enhance the productive traits of hybrid progeny of two breeds or two species. Although, there were multiple models for explaining the hybrid vigor, such as dominance and over-dominance hypothesis, its underlying molecular genetic mechanisms remain equivocal. The aim of this study is through comparing the different expression genes (DEGs) and different alternative splicing (DAS) genes to explore the mechanism of heterosis. Here, we performed a genome-wide gene expression and alternative splicing analysis of two heterotic crosses between donkey and horse in three tissues. The results showed that the DAS genes influenced the heterosis-related phenotypes in a unique than DEGs and about 10% DEGs are DAS genes. In addition, over 69.7% DEGs and 87.2% DAS genes showed over-dominance or dominance, respectively. Furthermore, the “Muscle Contraction” and “Neuronal System” pathways were significantly enriched both for the DEGs and DAS genes in muscle. TNNC2 and RYR1 genes may contribute to mule’s great endurance while GRIA2 and GRIN1 genes may be related with mule’s cognition. Together, these DEGs and DAS genes provide the candidates for future studies of the genetic and molecular mechanism of heterosis in mule.

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Systemic and molecular-genetic mechanisms of cardioprotection

Fiziolohichnyĭ zhurnal ◽

10.15407/fz57.05.051 ◽

2011 ◽

Vol 5 (57) ◽

pp. 51-54

Author(s):

AA Moĭbenko ◽

Keyword(s):

Molecular Genetic ◽

Genetic Mechanisms

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Clinical phenotypes and molecular genetic mechanisms of Carney complex

The Lancet Oncology ◽

10.1016/s1470-2045(05)70244-8 ◽

2005 ◽

Vol 6 (7) ◽

pp. 501-508 ◽

Cited By ~ 74

Author(s):

David Wilkes ◽

Deborah A McDermott ◽

Craig T Basson

Keyword(s):

Molecular Genetic ◽

Carney Complex ◽

Clinical Phenotypes ◽

Genetic Mechanisms

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Molecular-genetic mechanisms regulating tissue-specific expression of the drosophilaestS gene

Molecular Biology ◽

10.1007/bf02759598 ◽

2000 ◽

Vol 34 (5) ◽

pp. 622-627

Author(s):

L. I. Korochkin

Keyword(s):

Molecular Genetic ◽

Specific Expression ◽

Tissue Specific ◽

Tissue Specific Expression ◽

Genetic Mechanisms

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Development of the Nervous System of Invertebrates

The Oxford Handbook of Invertebrate Neurobiology ◽

10.1093/oxfordhb/9780190456757.013.3 ◽

2018 ◽

pp. 70-122

Author(s):

Volker Hartenstein

Keyword(s):

Nervous System ◽

Molecular Genetic ◽

Early Embryo ◽

Nerve Fibers ◽

Model Systems ◽

Animal Phyla ◽

Invertebrate Animals ◽

Genetic Mechanisms ◽

And Migration ◽

Complex Architecture

The complex architecture of the nervous system is the result of a stereotyped pattern of proliferation and migration of neural progenitors in the early embryo, followed by the outgrowth of nerve fibers along rigidly controlled pathways, and the formation of synaptic connections between specific neurons during later stages. Detailed studies of these events in several experimentally amenable model systems indicated that many of the genetic mechanisms involved are highly conserved. This realization, in conjunction with new molecular-genetic techniques, has led to a surge in comparative neurodevelopmental research covering a wide variety of animal phyla over the past two decades. This chapter attempts to provide an overview of the diverse neural architectures that one encounters among invertebrate animals, and the developmental steps shaping these architectures.

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Behavior and Molecular Genetics of the Five Factor Model

10.1093/oxfordhb/9780199352487.013.25 ◽

2015 ◽

Author(s):

Amber M. Jarnecke ◽

Susan C. South

Keyword(s):

Molecular Genetics ◽

Behavior Genetics ◽

Factor Model ◽

Five Factor Model ◽

Molecular Genetic ◽

Future Directions ◽

Genetics Research ◽

Genetic Mechanisms ◽

Genetic Techniques ◽

Related Personality

Behavior and molecular genetics informs knowledge of the etiology, structure, and development of the Five Factor Model (FFM) of personality. Behavior genetics uses quantitative modeling to parse the relative influence of nature and nurture on phenotypes that vary within the population. Behavior genetics research on the FFM has demonstrated that each domain has a heritability (proportion of variation due to genetic influences) of 40–50%. Molecular genetic methods attempt to identify specific genetic mechanisms associated with personality variation. To date, findings from molecular genetics are tentative, with significant results failing to replicate and accounting for only a small percentage of the variance. However, newer techniques hold promise for finding the “missing heritability” of FFM and related personality domains. This chapter presents an overview of commonly used behavior and molecular genetic techniques, reviews the work that has been done on the FFM domains and facets, and offers a perspective for future directions.

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