The Relationship Between Systemic Immune-Inflammation Index and TNM Stage in Patients Underwent Pancreatic Cancer Surgery

AbstractExosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Extensive studies indicate that exosomal RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) can interact with many types of cancers, associated with several hallmark features like tumor growth, metastasis, and resistance to therapy. Pancreatic cancer (PaCa) is among the most lethal cancers worldwide, emerging as the seventh foremost cause of cancer-related death in both sexes. Hence, revealing the specific pathogenesis and improving the clinical diagnosis and treatment process are urgently required. As the study of exosomes has become an active area of research, the functional connections between exosomes and PaCa have been deeply investigated. Among these, exosomal RNAs seem to play a significant role in the development, diagnosis, and treatment of PaCa. Exosomal RNAs delivery ultimately modulates the various features of PaCa, and many scholars have interpreted how exosomal RNAs contribute to the proliferation, angiogenesis, migration, invasion, metastasis, immune escape, and drug resistance in PaCa. Besides, recent studies emphasize that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for PaCa. In this review, we will introduce these recent insights focusing on the discoveries of the relationship between exosomal RNAs and PaCa, and the potentially diagnostic and therapeutic applications of exosomes in PaCa.

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Postoperative day five C-reactive protein predicts oncologic outcomes in pancreatic cancer surgery

HPB ◽

10.1016/j.hpb.2020.11.680 ◽

2021 ◽

Vol 23 ◽

pp. S269

Author(s):

P. Marcos-Santos ◽

M. Bailon-Cuadrado ◽

B. Perez-Saborido ◽

E. Asensio-Diaz ◽

P. Pinto-Fuentes ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Surgery ◽

Oncologic Outcomes ◽

C Reactive Protein ◽

Reactive Protein

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Evidence for enhanced recovery in pancreatic cancer surgery

Langenbeck s Archives of Surgery ◽

10.1007/s00423-020-01921-z ◽

2020 ◽

Vol 405 (5) ◽

pp. 595-602 ◽

Cited By ~ 1

Author(s):

Didier Roulin ◽

Nicolas Demartines

Keyword(s):

Pancreatic Cancer ◽

Enhanced Recovery ◽

Cancer Surgery

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Influence of Diet and Tobacco Smoking on Pancreatic Cancer Incidence in Poland in 1960–2008

Gastroenterology Research and Practice ◽

10.1155/2012/682156 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 8

Author(s):

Mirosław Jarosz ◽

Włodzimierz Sekuła ◽

Ewa Rychlik

Keyword(s):

Pancreatic Cancer ◽

Cancer Incidence ◽

Tobacco Smoking ◽

Red Meat ◽

Incidence Rates ◽

Dietary Factors ◽

Balance Sheets ◽

Animal Fats ◽

The Relationship ◽

Cancer Incidence Rates

The aim of the study was to investigate the relationship between pancreatic cancer incidence and selected dietary factors, alcohol consumption, and tobacco smoking in Poland in 1960–2008. Data on pancreatic cancer morbidity were derived from the National Cancer Registry and on food consumption from the national food balance sheets. In 1960–1989 correlations were found between pancreatic cancer incidence rates and energy (0.60 for males and 0.57 for females), cholesterol (0.87 and 0.80), fibre (−0.84 and −0.89) and folate (−0.45 and −0.49) intake, the consumption of total fats (0.94 and 0.91), animal fats (0,90 and 0,82), sugar (0.88 and 0.87), cereals (−0.93 and −0.91), and alcohol (0.86 and 0.82). In 1990–2008 morbidity correlated with the consumption of red meat (0.67 and 0.48), poultry (−0.88 and −0.57), and fruit (−0.62 and −0.50). Correlation with tobacco smoking was observed in the whole studied period (0.55 and 0.44). Increased incidence of pancreatic cancer in 1960–1995 was probably related to adverse dietary patterns up to 1989, especially high consumption of fats, sugar, and alcohol. Further positive changes in the diet such as lowering red meat consumption and increasing fruit consumption could influence incidence reduction in recent years. Also changes in tobacco smoking could affect the morbidity.

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