scholarly journals The Effect of Extremely Low Frequency Electromagnetic Fields on Visual Learning, Memory and Anatomical Structures of the Brain in Male Rhesus Monkeys

2018 ◽  
Vol 21 (1) ◽  
pp. 40-53
Author(s):  
Elahe Tekieh ◽  
Masomeh Kazemi ◽  
Hasan Tavakoli ◽  
Mehdi Saberi ◽  
Hosean Ghanaati ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Rhesus Monkeys ◽  
Visual Learning ◽  
Low Frequency ◽  
Anatomical Structures ◽  
Extremely Low Frequency ◽  
The Brain ◽  
Male Rhesus

scholarly journals The Effect of 12 Hz Extremely Low-Frequency Electromagnetic Fields on Visual Memory of Male Macaque Monkeys

2021 ◽  
Author(s):  
Masoomeh Kazemi ◽  
◽  
Hamed Aliyari ◽  
Elaheh Tekieh ◽  
Hassan Tavacoli ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Visual Memory ◽  
Rhesus Macaques ◽  
Low Frequency ◽  
Serum Levels ◽  
Control Group ◽  
Behavioral Tests ◽  
Extremely Low Frequency ◽  
Before And After ◽  
Male Rhesus

Introduction: Today, humans leave in a world surrounded by electromagnetic fields. Numerous studies have been carried out to discover the biological, physiological, and behavioral effects of electromagnetic fields on humans and animals. Given the biological similarities between monkeys and humans, the goal of the present research was to examine Visual Memory (VM), hormonal, genomic, and anatomic changes, and changes of the amygdala function in the male rhesus macaques who exposed to extremely low-frequency magnetic fields (ELF/MF). Materials and methods: Four male Rhesus Macaques (Macaca mulatta) were used. For the behavioral tests the animals were needed to be fasting for 17 hours, and for the behavioral tests such as visual memory, cooperation of the animal was necessary. Using the radiation protocol, two of the monkeys were exposed to 12-Hz electromagnetic fields with a magnitude of 0.7 microtesla (electromagnetic radiation) four hours a day for a month. Before and after the exposure, a visual memory test was conducted using a coated device (visible reward) on a movable stand. Ten mL of blood was obtained from the femoral artery of the monkeys and half of it was used to examine cortisol serum levels using MyBioSource kits (made in the USA). The other half of blood samples were used to extract lymphocytes for assaying expressions of Glucocorticoid Receptor (GR) genes before and after radiation using the PCR method. Anatomic studies of the amygdala were carried out based on pre- and post-radiation Magnetic Resonance Imaging (MRI). Findings: Research results indicated that visual memory in male primates increased significantly at the 12Hz frequency. Hormonal analysis at the 12Hz frequency showed a decrease in cortisol serum levels. However, visual memory and serum cortisol levels did not change considerably in male primates in the control group. There was no considerable amygdala volumetric difference at the 12 Hz frequency. The expression of the GR genes decreased at 12Hz compared to the control group. Conclusion: In short, these results indicated that ELF may have a beneficial value for memory enhancement as indicated by the fact that exposure to the 12 HZ ELF can enhance visual memory. This may be due to a decrease in plasma cortisol, and/or expression of GR genes. Moreover, direct involvement of the amygdala in this regard cannot be recommended.

scholarly journals Comparing the Impact of Long-Term Exposure to Extremely Low-Frequency Electromagnetic Fields With Diverse Values on Anxiety, Memory, Learning, And Β-Amyloid Deposition In Adult Rats

2021 ◽  
pp. 1-24
Author(s):  
Nafiseh Faraji ◽  
◽  
Iraj Salehi ◽  
Akram Alizadeh ◽  
Arash Pourgholaminejad ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Low Frequency ◽  
Amyloid Deposition ◽  
Control Group ◽  
Adult Rats ◽  
Male Adult ◽  
Extremely Low Frequency ◽  
Β Amyloid ◽  
The Impact ◽  
The Brain

Background: Extremely low-frequency electromagnetic fields (ELF-EMFs) have gathered significant consideration for their possible pathogenicity. However, their effects on nervous system functions were not fully clarified. In this study, our aim was to assay the effect of ELF-EMFs with different intensity on memory, anxiety, antioxidant activity, beta amyloid (Aβ) deposition and microglia population in rats. Materials and Methods: Fifty male adult rats were randomly separated into 5 groups; four groups exposed to a flux density of 1, 100, 500 and 2000 microtesla (µT), 50 Hertz (Hz) frequency for 1h/day for 2 months and one group as a control group. The control group were without ELF-EMF stimulation. After 8 weeks, passive avoidance and elevated plus maze (EPM) tests was performed to assess memory formation and anxiety-like behavior, respectively. Total free thiol groups and the index of lipid peroxidation were assessed. Also, for detection of β-Amyloid deposition and stained microglia in the brain, anti-β-amyloid and anti-Iba1 antibodies were used. Results: In the ELF-EMF exposure groups, the step-through latency was significantly greater in the retention test (100,500, and 2000 µT) than in the control group (P<0.05). Also, the percentage of the entries into the open arms in ELF-EMF exposure groups (especially 2000 µT) decreased than control group (P <0.05). No β-Amyloid depositions were detected in the hippocampus of different groups. An increase in microglia numbers in the 100, 500 and 2000 µT groups was observed in compare to the control and 1 µT group. Conclusion: Exposure to ELF-EMF had an anxiogenic effect on rats and promoted memory and also induced oxidative stress. No β-Amyloid depositions were detected in the brain. Also, positive effect of ELF-EMF was observed on population of microglia population in the brain.

Experimental delayed radiation necrosis of the brain

1979 ◽  
Vol 51 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Albert N. Martins ◽  
Ralph E. Severance ◽  
James M. Henry ◽  
Thomas F. Doyle
Keyword(s):  
Rhesus Monkeys ◽  
Radiation Necrosis ◽  
Clinical Signs ◽  
Control Group ◽  
Content Type ◽  
Brain Irradiation ◽  
Primate Brain ◽  
High Doses ◽  
The Brain ◽  
Male Rhesus

✓ The authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. Eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. For 1½ days before and 10½ days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and received saline. All animals eventually developed a progressive neurological syndrome, and died of delayed radiation necrosis of the brain. The two groups were compared with regard to latency to onset of clinical signs, survival time, and number, distribution, and location of lesions of radionecrosis. Large doses of dexamethasone did not alter the susceptibility of the primate brain to delayed radiation necrosis. Detailed morphological study of the radionecrotic lesions supports the hypothesis that most, if not all, of the lesions develop as the consequence of injury to blood vessels.

Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model

2013 ◽  
Vol 6 (1) ◽  
pp. 84-86 ◽  
Author(s):  
Inmaculada Tasset ◽  
Aleyda Pérez-Herrera ◽  
Francisco J. Medina ◽  
Óscar Arias-Carrión ◽  
René Drucker-Colín ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Electromagnetic Fields ◽  
Rat Model ◽  
Low Frequency ◽  
Extremely Low Frequency
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