scholarly journals Oral administration of triethylenetetramine (TETA) reduces some inflammatory markers in streptozotocin-induced diabetes mellitus in rat

2018 ◽  
Vol 5 (3) ◽  
pp. 23-31
Kaveh Azimzadeh ◽  
Hossein Jafarpour ◽  
Farid Digeleh ◽  
Armin Gargarechi ◽  
2009 ◽  
Vol 54 (2) ◽  
pp. 931-933 ◽  
Unji Lee ◽  
Young H. Choi ◽  
So H. Kim ◽  
Byung K. Lee

ABSTRACT After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC0-24) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats.

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S120-S121
TH. LINN ◽  

2019 ◽  
pp. 1-3
Bertrand Ng ◽  
Arafat Yasser

Omental infarct is a rare cause of an acute abdomen that arises from an interruption of blood supply to the omentum. Here, we present a case of omental infarct in a 67-year-old gentleman with background history of diabetes mellitus who present unusually with a severe acute onset right hypochondrium pain. Examination revealed that he was tender to touch at the right and was having localized guarding. His inflammatory markers were normal. He was successfully treated with laparoscopy surgery and he was subsequently discharged the following day. Omental infarct cases with right hypochondrium pain can sometimes mimicked acute cholecystitis and management includes laparoscopic surgery which can hasten symptoms resolution and reduces hospital stay, however recommendation for surgery has to be balanced with anesthetics risk and complication of the surgery itself.

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