scholarly journals Determining the Effective Factors on Gastric Cancer Using Frailty Model in South-East and North of Iran

2017 ◽  
Vol 5 (3) ◽  
pp. 35-48 ◽  
Author(s):  
Roja Nikaeen ◽  
Alireza Khalilian ◽  
Abbas Bahrampour ◽  
◽  
◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Frailty Model ◽  
Effective Factors ◽  
North Of Iran

scholarly journals Study of cyp2E1 gene RsaI/PstI polymorphisms in patients with gastric cancer in north of Iran

2016 ◽  
Vol 4 (4) ◽  
pp. 22-27
Author(s):  
Samaneh Kamalipour ◽  
Ali Barzegar ◽  
Novin Nikbakhsh ◽  
Mohamad Shokrzadeh ◽  
◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cyp2e1 Gene ◽  
North Of Iran

scholarly journals Correlation between the Expression Levels of miR-21 and miR-192 and Clinicopatological Features in Plasma of Patients with Gastric Cancer in Iran

2021 ◽  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Area Under The Curve ◽  
Tumor Stage ◽  
Expression Levels ◽  
The North ◽  
Study Results ◽  
Noninvasive Biomarker ◽  
North Of Iran ◽  
Gastric Cancer Patients

Background: Gastric cancer (GC) is the most prevalent malignancy worldwide and a common cause of death in Iran. Studies have proved that a variety of dysregulated microRNAs is involved in the development and progression of gastric cancer. The present study aimed to evaluate the expression levels of plasma circulating oncogenic miR-21 and miR-192 and their association with clinical phenotypes of patients with gastric cancer in the north of Iran. Material and Methods: Clinico-pathological analysis was conducted using a standard protocol and pathological tests. The expression levels of miR-21 and miR-192 were measured using quantitative reverse transcription-polymerase chain reaction in the plasma of twenty pre/post-operative gastric cancer patients and twenty healthy subjects. The receiver operating characteristic (ROC) curve of these microRNAs was analyzed to investigate their diagnosis properties. Results: The study results indicated that plasma miR-21 expression was significantly associated with tumor stage and helicobacter pylori infection status (P=0.024, P=0.0004, respectively). However, no association was observed between clinic-pathological characteristics and miR-192 expression. The results showed that the plasma levels of miR-21 (P=0.0001) and miR-192 (P=0.0007) were significantly higher in GC patients compared to those in healthy individuals. Furthermore, the ROC analyses yielded the area under the curve (AUC) values of 0.9525±0.03 (P<0.0001) and 0.5925±0.09 (P=0.316) for miR-21and miR-192, respectively. Pearson regression analysis showed that there was no significant correlation between the expression of miR-21 and miR-192 (P=0.1507). Conclusion: Based on the obtained results, the expression of the plasma level of miR-21 was significantly higher in gastric cancer patients compared to that in the healthy group. Furthermore, the higher levels of AUC in miR-21 indicated the potential role of miR-21 as a noninvasive biomarker for the prognosis of gastric cancer in the population of the north of Iran.

Aphthous Ulcer and the Effective Factors on It`s Incidence among the Students of Golestan Medical Sciences University in the North of Iran

2007 ◽  
Vol 7 (5) ◽  
pp. 830-832 ◽  
Author(s):  
Saeedeh Eris ◽  
Ezzat Ollah Ghaemi . ◽  
Abdolvahab Moradi . ◽  
Azad Reaza Mansouria . ◽  
Mohammad Reza Rabiei . ◽  
...  
Keyword(s):  
Aphthous Ulcer ◽  
Medical Sciences ◽  
Effective Factors ◽  
The North ◽  
North Of Iran

scholarly journals Correlation of –160C > A and –347GA > G polymorphisms in E-cadherin gene and gastric cancer in north of Iran

2021 ◽  
Vol 26 (1) ◽  
pp. 3
Author(s):  
MohammadBagher Hashemi-Soteh ◽  
Ramin Shekarriz ◽  
Reza Alikhani ◽  
Mohaddeseh Ghasemi ◽  
RezaAlizadeh Navaei
Keyword(s):  
Gastric Cancer ◽  
North Of Iran ◽  
E Cadherin

scholarly journals Survival Rate of Patients with Gastric Cancer and effective factors in two referral hospitals of Mashhad, Iran: A Multiple Regression Analysis

10.19082/7831 ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 7831-7837
Author(s):  
Zahra Yousefli ◽  
Ladan Goshayeshi ◽  
Hamid Heidarian Miri ◽  
Naiemeh Farhangnezhad ◽  
Aida Ghofrani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Regression Analysis ◽  
Survival Rate ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Effective Factors ◽  
Referral Hospitals

scholarly journals Evaluation of NOS2 Polymorphism in Gastric Adenocarcinoma Patients in Mazandaran Province

2021 ◽  
Author(s):  
Mahshad Hooshyar ◽  
Saeed Abedian-Kenari ◽  
Abbas Mohammadpour ◽  
Habibeh Mirmajidi ◽  
Majid Jafari-Sabet ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Cancer ◽  
Control Group ◽  
Polymorphism Analysis ◽  
Mazandaran Province ◽  
Risk Area ◽  
Chi Square ◽  
High Risk Area ◽  
North Of Iran ◽  
Oxide Synthase

Introduction: Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwide. North of Iran is a high-risk area for gastric cancer. Nitric oxide (NO), mainly synthesized by inducible nitric oxide synthase (NOS2) in pathological conditions, plays an important role in cytotoxicity, inflammation and fibrosis. In this research we studied the effect of (rs1137933) T>C genotype on gastric cancer. Methods: This analysis was performed on 93 patients with gastric cancer who were referred to endoscopy Tuba Clinic in 2015 and 93 healthy individuals as controls. DNA extracted from peripheral blood samples was applied in PCR-RFLP (Polymerase chain reaction- restriction fragment length polymorphism) analysis to determine (rs1137933) T>C genotype. The association of the (rs1137933) T>C genotype and gastric cancer risk were analyzed by MedCalc software and (X2) Chi-square and (OR) Odds Ratio exams. Results: Frequency of TT, CT, and CC genotypes in cases was 12.61, 51.35 and 36% and 38.7, 34.4, and 26.8% in the control group. Significant association was found between (rs1137933) T>C genotype with gastric cancer chance, P<0.05, OR=2/04, 95% CI (1/37 to 3/03). Conclusion: The results of the study show that the presence of CC+CT genotypes may increase the risk of gastric cancer.  P < 0.0001, OR=4.37 (2.17 to 8.80).Therefore, investigating the (rs1137933) T>C single nucleotide polymorphism of NOS2 gene could be an appropriate molecular marker that could be used to determine individual sensitivity to gastric cancer and for designing cancer prevention programs.

scholarly journals Demographic and clinical characteristics of gastric cancer patients in north of Iran, Mazandaran province, 2008-2014

2015 ◽  
Vol 1 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Seyed Khalil Mousavi ◽  
Ghasem Janbabai ◽  
Bizhan Kouchaki ◽  
Hanieh Borhani ◽  
Masoumeh Rashidi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Mazandaran Province ◽  
North Of Iran ◽  
Gastric Cancer Patients

scholarly journals Effective Factors on the Recurrence of Bipolar Mood Disorder I in an Iranian Population Sample Using the Frailty Model with Bayesian Approach

2021 ◽  
Author(s):  
Habiballah Esmaeeli ◽  
Ali Talaei ◽  
Zahra Arab Borzu ◽  
Soleiman Kheyri ◽  
Monire Raeesi ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Head Trauma ◽  
Bayesian Approach ◽  
Population Sample ◽  
Frailty Model ◽  
Bipolar I Disorder ◽  
Effective Factors ◽  
Risk Of Recurrence ◽  
History Of ◽  
Depressive Episodes

Objective: Bipolar I disorder is one of the most frequent mental disorders characterized by manic or mixed +/- depressive episodes. Drug treatment has been proved to diminish next episodes, but many other factors are important for exacerbating the conditions. This study aimed to investigate the effective factors on the time and number of episodes in these patients by applying the shared frailty model. Method: In this retrospective longitudinal study, the information of 606 patients with bipolar I disorder, admitted for the first time in Ibn-e-Sina psychiatric hospital in Mashhad from the beginning of 2007 until the end of 2009 were used. These patients were followed up until the end of 2018 for readmission. The Cox model with gamma frailty and Bayesian approach were used to determine the effective factors of frequent recurrences. Results: History of head trauma, substance abuse, and legal conflict had a positive impact on recurrences, while age had a negative effect on recurrences and the risk of recurrence was higher in younger people (P < 0.05). The variance estimation of frailty effect was 0.97 that indicates a correlation between the recurrence intervals of bipolar I patients, owing to a heterogeneity among patients. Conclusion: Based on the results, a higher risk of recurrence of bipolar I disorder was found in younger patients and those with a history of head trauma, substance abuse, and legal conflicts. Further investigations are required to account for the genetic factor and psychosocial exposure during critical periods applying this model.

Sign in / Sign up

Export Citation Format

Share Document