scholarly journals ARRHYTHMOGENESIS IN MITRAL VALVE PROLAPSE

2015 ◽  
Vol 22 (02) ◽  
pp. 227-234
Author(s):  
Muhammad Alamgir Khan ◽  
Syed Muhammad Imran Majeed ◽  
Faizania Shabbir ◽  
Tausif Ahmed Rajput

Mitral valve prolapse is generally considered a benign condition, however, asubset of patients remains at high risk of arrhythmogenesis which may lead to sudden cardiacdeath. Objective: To stratify risk of arrhythmogenesis in patients with mitral valve prolapseon the basis of high resolution ECG, Holter monitoring, resting heart rate and mitral leafletgeometry. Study Design: Cross sectional comparative study. Place of study: Armed ForcesInstitute of Cardiology (AFIC)/National Institute of Heart Diseases, Rawalpindi and Army MedicalCollege, Rawalpindi, Pakistan Methodology: Mitral leaflet displacement and thickness weremeasured on echocardiography in 37 patients with mitral valve prolapse. Resting heart rateand time domain indices of heart rate variability of each patient were recorded from 24 hoursHolter monitoring. High resolution ECG of all the patients was carried out to record ventricularlate potentials. Statistical analysis was performed using SPSS and the alpha value was set at<0.05 for significance. Results: The mean values for resting heart rate, leaflet displacement andleaflet thickness were 77.19±6.29 per minute, 3.64±0.92 mm and 4.96±0.79 mm respectively.Ventricular late potentials were present in 8 (21.62%) whereas heart rate variability was reducedin 5 (13.51%) patients. Leaflet thickness was significantly greater in patients with ventricularlate potentials as compared to those without (p-value 0.004). Patients with reduced heart ratevariability had significantly higher resting heart rate as compared to those with normal variability(p-value 0.02). One patient (2.7%) had ventricular late potentials, reduced heart rate variability,resting heat rate of 88 beats per minute and leaflet thickness over 5 mm. Conclusions:Combined effects of high resolution ECG, holter monitoring and leaflet geometry identified thehigh risk subset, comprising of 2.7% of the study population.

PEDIATRICS ◽  
1995 ◽  
Vol 95 (5) ◽  
pp. 789-790
Author(s):  

Mitral valve prolapse (MVP) is generally a benign condition characterized by the protrusion of the mitral valve leaflets into the left atrium during systole. The prevalence of MVP in individuals under the age of 18 years is estimated to be 5% but is higher in those with Marfan's syndrome and other collagen vascular disorders.1 A midsystolic nonejection click with or without a late systolic murmur is the auscultatory hallmark of this syndrome. The diagnosis of MVP in children and adolescents should be based primarily on auscultatory findings and not on minor echocardiographic findings.1 The prognosis in children and adolescents with isolated MVP appears to be excellent and complications are rare. In 553 children, aged 15 days to 18 years, who were involved in studies with a follow-up period of 6 to 9 years, the following were reported: subacute bacterial endocarditis (one case), cerebral vascular accidents (two cases), migraine headaches (four cases), and chest pain (12 cases).2,3 Only four cases of sudden death have been reported in patients younger than 20 years of age.1-4 In a study of 103 patients with MVP, 16% were found to have premature ventricular beats during exercise electrocardiography (ECG) (exercise test).3 Thirty-eight percent were found to have premature ventricular contractions (PVCs) on 24-hour ECG (Holter) monitoring. This study, however, does not report the true prevalence of dysrhythmias because all these subjects had been referred to a pediatric cardiologist for evaluation. It is likely that these reported numbers are high because asymptomatic patients are less often referred.


1993 ◽  
Vol 7 (4) ◽  
pp. 210-214 ◽  
Author(s):  
S. Marangoni ◽  
S. Scalvini ◽  
R. Mai ◽  
A. Quadri ◽  
G.F. Levi

1998 ◽  
Vol 28 (12) ◽  
pp. 1973
Author(s):  
Yung Woo Shin ◽  
Hyun Myung Oah ◽  
Jong Won Kim ◽  
Taek Jong Hong

2020 ◽  
Vol 9 (4) ◽  
pp. 1121
Author(s):  
Elena Reginato ◽  
Danila Azzolina ◽  
Franco Folino ◽  
Romina Valentini ◽  
Camilla Bendinelli ◽  
...  

Assessment of heart rate variability (HRV) and cardiac ectopic beats is a clinically relevant topic. The present exploratory observational study aimed to inspect the relationships of lifestyle, dietary patterns, and anthropometrics with HRV, premature ventricular complexes (PVCs), and supraventricular premature complexes (SVPCs). A cross-sectional study enrolling subjects undergoing Holter monitoring was performed. Sociodemographic and clinical characteristics, body composition (full-body bio-impedentiometry), dietary patterns (validated food frequency questionnaire and 24 h dietary recall), and quality of life were assessed. Generalized additive models were estimated to evaluate the relationships between outcomes of interest and variables collected. The study enrolled 121 consecutive patients undergoing 24 h Holter monitoring. Upon univariable analysis, HRV was found to have an inverse association with mass of body fat (MBF) (p-value 0.015), while doing physical activity was associated with a significantly higher HRV (p-value 0.036). Upon multivariable analysis, fruit consumption in the 24 h dietary recall was found to be directly associated with HRV (p-value 0.044). The present findings might be useful for improving the management of patients attending cardiac rhythm labs, and to tailor ad hoc prevention strategies (modification of lifestyle and eating habits) based on Holter parameters.


2013 ◽  
Vol 22 (3) ◽  
pp. e33
Author(s):  
Ya-chu Chen ◽  
Lung-Wen Tsai ◽  
Ing-Fang Yang ◽  
Chung-Kai Tseng ◽  
Ten-Fang Yang

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