scholarly journals Correlation of vitamin D3 and serum calcium level with left ventricular hypertrophy patients.

2020 ◽  
Vol 27 (06) ◽  
pp. 1143-1150
Author(s):  
Masood Nabi Noor ◽  
Anawar Ali Jamali ◽  
Hajra Naila Rahu ◽  
Ghulam Mustafa Jamali ◽  
Altaf Hussain Memon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Ventricular Hypertrophy ◽  
Serum Vitamin ◽  
Left Ventricular ◽  
Serum Vitamin D ◽  
25 Hydroxycholecalciferol

Extra cellular fluid (ECF) Ca++ performs vital functions such as blood clotting, cardiac muscle contraction, second messenger for hormone and neurotransmitter release. Total Ionized serum Ca++ is 4.65 to 5.25 mg/dl Ionized Ca++ performs vital physiological functions such as maintenance of plasma membrane integrity. Objectives: The present study is the first research being reporting on the association of LVH (left ventricular hypertrophy) due to essential hypertension with serum vitamin D3 and serum calcium levels. Study Design: Cross Sectional Research. Setting: Medicine/Cardiology department, Peoples Medical University Hospital, Nawabshah. Period: 1st January 2017 to 30th June 2017. Material & Methods: To assess the correlation of 25-hydroxycholecalciferol and serum calcium with left ventricular hypertrophy in essential hypertension. The thickness of inter ventricular septum (IVS) and posterior wall (PWT) on echocardiography were used to categorize LVH into mild, moderate and severe. Results: Male predominated in the present study. Male to female ratio was 1.65:1. Male and female comprised 62.33% and 37.67% respectively. Chi square value (X2-value) was 14.7 with significant p-value. Mean +SD of 25-hydroxycholecalciferol in mild moderate and severe LVH were noted as 30+7.8, 24.7+7.7 and 14.9+6.1 ng/dl respectively. Mean +SD of serum calcium in mild moderate and severe LVH were noted as 9.20+0.51, 8.93+0.72 and 8.678+0.44 mg/dl respectively. Conclusion: In subjects with left ventricular hypertrophy in essential hypertension the serum levels of vitamin D and calcium were low. There was a negative correlation with left ventricular hypertrophy and serum vitamin D and serum calcium. Thus it could be concluded that in subjects with left ventricular hypertrophy the low levels of serum vitamin D could be an independent modifiable risk factor.

Association of serum vitamin D with left ventricular hypertrophy in hypertensive patients

2014 ◽  
Vol 8 (4) ◽  
pp. e65
Author(s):  
Katarzyna Stolarz-Skrzypek ◽  
Agnieszka Olszanecka ◽  
Wiktoria Wojciechowska ◽  
Danuta Czarnecka
Keyword(s):  
Vitamin D ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Serum Vitamin ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Serum Vitamin D

ID: 86: SAFETY OF 50,000-100,000 UNITS OF VITAMIN D3 PER WEEK IN VITAMIN D DEFICIENT, HYPERCHOLESTEROLEMIC PATIENTS, WITH STATIN INTOLERANCE

2016 ◽  
Vol 64 (4) ◽  
pp. 929.2-930
Author(s):  
V Jetty ◽  
G Duhon ◽  
P Shah ◽  
M Prince ◽  
K Lee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
High Serum ◽  
Statin Intolerance ◽  
Serum Vitamin D ◽  
Median Serum

BackgroundIn ∼85–90% of statin intolerant patients, vitamin D deficiency (serum 25 (OH) D <32 ng/ml) is a reversible cause of statin intolerance, usually requiring 50,000 to 100,000 units of vitamin D/week continuously to normalize serum vitamin D, and thus successfully allow reinstitution of statins which previously could not be tolerated because of myalgia-myositis.Specific AimIn 274 statin intolerant patients, all with low entry serum vitamin D (<32 ng/ml, median 21 ng/ml), we assessed safety and efficacy of vitamin D supplementation (50,000–100,000 units/week) over treatment periods of 3 months (n=274), 3 and 6 months (n=161), 3, 6, and 9 months (n=58), and 3, 6, 9, and 12 months (n=22).ResultsIn the 385 patients with 3 month follow-up, taking mean 61,000 and median 50,000 IU of vitamin D3/week, median serum vitamin D rose from 20 to 42 ng/ml (p<0.0001); vitamin D became high (>100 ng/ml) but not toxic-high (>150 ng/ml) in 4 patients (1.0%) (101, 102, 106, 138 ng/ml). Median serum calcium was unchanged from entry (9.6 mg/dl) to 9.6 at 3 months. On vitamin D supplementation, the trend of change in serum calcium from normal-to-high or from high-to-normal did not significantly differ (McNemar S=1.0, p=0.32), and there was no significant trend in change of the calculated glomerular filtration rate (eGFR) from entry to follow-up (McNemar S=2.6, p=0.11).In the 161 patients with 3 and 6 month follow-up, taking mean 67,000 and median 50,000 IU of vitamin D3/week, median entry serum vitamin D rose from 21 to 42 to 44 ng/ml (p<0.0001), serum vitamin D was high (>100 but <150 ng/ml) in 2 patients at 3 months (1.2%, 101, 102 mg/ml) and in 3 (1.9%) at 6 months (101, 140, 140 ng/ml). Median serum calcium was unchanged from entry (9.7 mg/dl), at 3 and 6 months (9.7, 9.6 mg/dl, p>0.05). On vitamin D supplementation, the change in serum calcium from normal-to-high or high-to-normal was no significant trend (McNemar S=0.7, p=0.41), and no trend in change of eGFR (McNemar S=1.3, p=0.26).In the 58 patients with 3, 6, and 9 month follow-up on mean and median 71,000 and 100,000 IU of D3/week, median entry vitamin D rose from 20 to 37, 41, and 44 ng/ml (p<0.0001), with 1 (1.7%, 102 ng/ml), 2 (3.5%, 140, 140 ng/ml), and 0 (0%) patients high. Median serum calcium was unchanged from entry, median 9.7, 9.8, 9.6, and 9.6 mg/dl. On vitamin D supplementation, the trend of change in serum calcium from normal-to-high or high-to-normal was not significant (McNemar S=1.8, p=0.18), and no trend in change of eGFR (McNemar S=2, p=0.16).In the 22 patients with follow-up at 3, 6, 9, and 12 months on mean and median 70,000 and 75,000 IU of D3/week, median serum vitamin D rose from 20 to 37, to 41, to 44, and to 43 ng/ml (p<0.0001), with 1 (5%, 102 ng/ml) high, 2 (9%, 140, 140) high, 0 (0%) high, and 1 (5%, 126 ng/ml) high. Serum calcium was unchanged, median at entry 9.6, and then at 3, 6, 9, and 12 months 9.7, 9.7, 9.5, and 9.7 mg/ml. At entry serum calcium was normal in 21, none high, and one became high at 12 month follow-up. The trend of change in eGFR was insignificant, McNemar S=1.0, p=0.32.When serum D rose above 100 ng/ml in the few cases, as above, it fell into the normal range within 2 weeks by reducing the vitamin D dose by 50%.ConclusionsWhen 50,000–100,000 units of vitamin D/week are given to reverse statin intolerance in statin intolerant patients with low entry vitamin D (<32 ng/ml), it appears to be safe over up to 1 year follow-up, without toxic high serum vitamin D levels >150 ng/ml, and levels rarely >100 ng/ml, and without changes in serum calcium or eGFR.

scholarly journals Correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 971
Author(s):  
Divya V. Patil ◽  
Tarun Kumar Dutta
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Essential Hypertension ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Sunlight Exposure ◽  
P Value ◽  
Lower Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D, a fat-soluble vitamin is produced when ultraviolet rays from sunlight strike the skin. Literature data supports, there is a relationship between low vitamin D and pathogenesis of cardiovascular diseases and arterial hypertension. It had been seen that lower circulating 25(OH)D levels were associated with higher blood pressures. Aim was to study the correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals.Methods: An observational study was conducted on 60 individuals in the OPD at MGMCRI between January 2018 and December 2018. Based on history and blood pressure values (JNC 7), the population was divided into cases and controls in accordance with the age and sex. Serum Vitamin D levels were measured by chemiluminescence assay and classified into deficiency (<20ng/ml), insufficiency (20-30ng/ml) and sufficiency (30-100ng/ml). Statistical analysis was done using independent t test, one way ANOVA and correlation.Results: Among the hypertensive individuals, 90% were Vitamin D deficient and 10% had insufficiency. The mean Serum Vitamin D level in essential hypertension was 14.6±4.401 (p value <0.001). Serum Vitamin D levels were affected significantly by increasing BMI (p value <0.001) and less sunlight exposure (p value <0.001) among both cases and controls. There was also a significant negative correlation between serum vitamin D levels and systolic blood pressure (p <0.001).Conclusions: Isolated systolic hypertension was associated with lower serum Vitamin D levels. Obesity and reduced sunlight exposure are factors associated with lower serum Vitamin D levels.

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

scholarly journals Cardiac Arrhythmias and Left Ventricular Hypertrophy in Dipper and Nondipper Patients With Essential Hypertension

2000 ◽  
Vol 64 (7) ◽  
pp. 499-504 ◽  
Author(s):  
Hiroshi Ijiri ◽  
Isao Kohno ◽  
DongFeng Yin ◽  
Hiroshi Iwasaki ◽  
Masahiro Takusagawa ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Arrhythmias ◽  
Ventricular Hypertrophy ◽  
Left Ventricular

scholarly journals ASSESSMENT OF VITAMIN D THERAPY EFFECT ON INFLAMMATORY MARKERS IN PEDIATRIC PATIENTS WITH TYPE I DIABETIC

2018 ◽  
Vol 11 (10) ◽  
pp. 552 ◽  
Author(s):  
Kadhim Ali Kadhim ◽  
Lubab Tarek Nafea ◽  
Hayder A Fawzi ◽  
Esraa Abdul-al Hameed ◽  
Gaith Ali Gasim
Keyword(s):  
Vitamin D ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Pediatric Patients ◽  
Serum Vitamin ◽  
Type I ◽  
Insulin Regimen ◽  
Newly Diagnosed ◽  
Daily Insulin ◽  
Therapy Effect

Objective: The objective of this study is to estimate the effect of Vitamin D3 supplementation on endogenous Vitamin D3 level and inflammatory biomarkers in newly diagnosed pediatric patients.Methods: The patients were given oral Vitamin D3, and they divided into three groups: The first group (25 healthy pediatrics), the second group (25 newly diagnosed pediatric patients) treated with daily insulin regimen only, and the third group (25 newly diagnosed pediatric patients) treated with Vitamin D3 (2000 IU/day) with daily insulin regimen; all patients were treated for 90 days; and blood samples were taken at baseline and after 45 days and 90 days of starting Vitamin D3 to assess its potential effect on the levels of Vitamin D, serum calcium, serum alkaline phosphatase levels, and other inflammatory markers.Results: The results of the current study showed that serum IL-1β significantly declined in patients receiving Vitamin D3, while serum Vitamin D3, serum calcium, and interleukins-4 were significantly increased in patients receiving Vitamin D3.Conclusion: Vitamin D3 in a daily dose of 2000 IU/day for 90 days results in favorable immune response and increase of serum Vitamin D3 for pediatric new diagnosed Type 1 diabetes mellitus patients.

Sign in / Sign up

Export Citation Format

Share Document