scholarly journals Efficacy of clomiphene citrate versus letrozole in attaining optimum follicular growth.

2020 ◽  
Vol 27 (11) ◽  
pp. 2478-2482
Author(s):  
Nisa Mohsin
Keyword(s):  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Reproductive Age ◽  
University Hospital ◽  
Obstetrics And Gynecology ◽  
Endocrine Disorders ◽  
Follicular Growth ◽  
Number Of Patients ◽  
Group 2 ◽  
Group 1

Department of Obstetrics and Gynecology, Isra University Hospital Sindh Pakistan. Objectives: To compare the efficacy of clomiphene citrate versus letrozole in attaining optimum follicular growth among infertile women of reproductive age group in Isra University Hospital Hyderabad. Study Design: Randomized Controlled trial. Setting: Department of Obstetrics and Gynecology, Isra University Hospital Sindh, Pakistan. Period: May 2016 to November 2016. Material & Methods: A total of 128 women with anovulation due to known endocrine disorders were included in this study. These were randomly allocated in group 1 and 2. Group 1 consisted of 64 women received 50mg of clomiphene citrate and 64 in group 2, treated with letrozole. Proformas were filled and results regarding the drug achieving follicular diameter of >18mm by Trans abdominal Ultrasound in maximum number of women in any of the group was supervised by consultant gynecologist practicing for more than 10 years. Stastical analysis was done using SPSS version 19.The average age of women was 27.21+3.21. Number of patients with primary infertility were 60 (93.8%) and 57 (89.1%) in group 1 and 2 respectively while secondary infertility was observed in 4 (6.3%) and 7(10.9%) in group 1 and 2 respectively. Regarding endocrine disorders, 34 (26.6%) were polycystic ovaries and 35(27.3%) hypothalamic. Results: The average age of women was 27.21±3.21 years. Efficacy was significantly high in clomiphene citrate (group 1) as compared to letrozole (group 2) [92.19% vs 79.69%; p=0.042]. Conclusion: This study demonstrates that clomiphene citrate is superior to letrozole as an inducer of ovulatory cycles. However there is need for larger well designed randomized trials to generate robust data in order to establish the true potential of clomiphene.

scholarly journals The effect of hormonal disbalance on the aging rate change in the patients with arterial hypertension and comorbid endocrinopathies

2019 ◽  
Vol 23 (2) ◽  
pp. 277-282
Author(s):  
V. D. Nemtsova ◽  
I. A. Ilchenko ◽  
V. V. Zlatkina
Keyword(s):  
Arterial Hypertension ◽  
Premature Aging ◽  
Endocrine Disorders ◽  
Anthropometric Parameters ◽  
Aging Rate ◽  
Age Related ◽  
Number Of Patients ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Due to the growing number of patients with age-related diseases, the aim of the study was to investigate in the changes of aging rate (AR) in patients with comorbid course of arterial hypertension (H), type 2 diabetes mellitus (T2DM) and subclinical hypothyroidism (SH) and to study the features of these changes depending on hormonal imbalance. 118 patients (63 women and 55 men, average age — 53.6±4.3 years) were divided into 3 groups: group 1 (n=37) with isolated H; group 2 (n=42) — with H and T2DM; group 3 (n=39) — with H, T2DM and SH. The investigation program included: measurement of anthropometric parameters (blood pressure, height, body weight (BW), body mass index (BMI)), carbohydrate and thyroid metabolism using standard methods, biological age (BA) by V.P. Voitenko et al. Statistical processing was performed using the Statistica for Windows 8.0 software package. When evaluating AR, physiological aging was found in 8 patients (21.6%) of group 1, in 4 (9.5%) patients of group 2 and 3 (7.7%) of patients in group 3. In the overwhelming majority of the examined patients, premature aging (PA) was noted, however, the acceleration of PA between patients of groups 2 and 3 was not differ significantly (p>0.05). The increase in AR in group 2 patients was accompanied by an increase in BA by 7.2 years, in 3 group patients — by 7.3 years compared with their chronological age. A correlation analysis revealed a positive relationship between BMI and coefficient of aging rate (CAR) (r=0.679; p<0.05); BMI and BA (r=0.562; p<0.05) and CAR and the TSH level (r=0.050; p=0.388) in the 3rd group. Thus, the presence of hypertension and comorbid endocrinopathies — T2DM and SH significantly increases the AR and when assessing the effect of endocrine disorders, the presence of T2DM is more important than SH.

P-681 Will the hCG trigger dose used for final oocyte maturation in IVF impact endogenous progesterone during the luteal phase? - A randomized controlled trial

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
L Svenstrup ◽  
J Fedder ◽  
S Möller ◽  
D Pedersen ◽  
K Erb ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Luteal Phase ◽  
Controlled Trial ◽  
University Hospital ◽  
Final Oocyte Maturation ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
Significant Difference ◽  
Hcg Trigger ◽  
Group 1

Abstract Study question Is there an association between the hCG dose used for ovulation trigger and the endogenous progesterone production during the luteal phase? Summary answer Increased hCG dosing significantly increased the endogenous progesterone level during the luteal phase. What is known already During the luteal phase of an IVF treatment, the endogenous progesterone (P4) production is negatively impacted due to reduced circulating endogenous LH, caused by negative feed-back of elevated steroids; thus, luteal phase support (LPS) with exogenous P4 remains mandatory in IVF. Apart from inducing final oocyte maturation, the gold standard HCG trigger also functions as an early LPS, boosting P4 production by the corpora lutea (CL). P4 plays a pivotal role for embryo implantation and pregnancy, and an optimal P4 level around peri-implantation seems to be essential for the reproductive outcomes of fresh and frozen/thaw embryo transfer cycles. Study design, size, duration A randomized controlled 4-arm study, including a total of 127 IVF patients, enrolled from January 2015 until September 2019 at the Fertility Clinic, Odense University Hospital, Denmark. Participants/materials, setting, methods IVF patients with ≤ 11 follicles ≥ 12 mm were randomized to four groups. Groups 1-3 were triggered with: 5.000 IU, 6.500 IU or 10.000 IU, hCG, respectively, receiving a LPS consisting of 17-α-hydroxy-progesterone (17α OH P4) to distinguish the endogenous P4 from the exogenous supplementation. Group 4 (control) was randomized to a 6.500 IU hCG trigger and standard LPS. A total of eight blood samples were drawn during the early luteal phase. Main results and the role of chance A total of 94 patients completed the study: 21, 22, 25 and 26 patients in each group, respectively. Baseline characteristics were similar, except for the endogenous LH level and cycle lengths. There were no significant differences between groups regarding ovarian stimulation, number of oocytes and embryos. The median number of follicles ≥ 12mm on the day of trigger was 8.5, resulting in 6.6 oocytes being retrieved. Significant differences in P4 levels were seen at OPU+8 (p &lt; 0.001), OPU+10 (p &lt; 0.001) and OPU+14 (p &lt; 0.001), with positive correlations between P4 level and hCG dose. Groups compared individually showed significant difference in P4 between low and high trigger dose at OPU+4 group 1 and 3 (p = 0.037) and OPU+8 group 1 and 3 (p = 0.007) and between all the three groups around implantation at OPU+6 group 1 and 2 (p = 0.011), group 2 and 3 (p = 0.042) and group 1 and 3 (p &lt; 0.001). Higher P4 levels around implantation were related to follicle count and to pregnancy. After logistic regression analyses there were still significant individual differences between the groups. Limitations, reasons for caution Although patients were randomized and strict inclusion and exclusion criteria were used, the RCT was un-blinded, including a relatively small number of patients. Moreover, for dosing purposes urinary hCG as well as recombinant hCG was used and pharmacokinetics differ. Finally, the P4 level could be influenced by circadian fluctuations. Wider implications of the findings This is the first study to explore dose-responses in circulating P4 after hCG trigger in IVF patients. Increasing the hCG trigger dose increased the endogenous P4 around peri-implantation. Personalizing the hCG trigger dose could be a key point to secure the most optimal P4 mid-luteal phase P4 level. Trial registration number Eudract 2013-003304-39

Role of intermittent pneumatic compression in the treatment of breast cancer–related lymphoedema: a randomized controlled trial

2019 ◽  
Vol 34 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Engin Tastaban ◽  
Aykut Soyder ◽  
Elif Aydin ◽  
Omer Faruk Sendur ◽  
Yasemin Turan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Excess Volume ◽  
Controlled Trial ◽  
Intermittent Pneumatic Compression ◽  
University Hospital ◽  
Randomized Controlled ◽  
Group 2 ◽  
Group 1

Objective: To evaluate the role of intermittent pneumatic compression in the treatment of breast cancer–related lymphoedema. Design: Randomized controlled trial. Setting: Physical medicine and rehabilitation clinic at a university hospital. Subjects: Seventy-six patients with lymphoedema. Interventions: Patients were allocated into Group 1 (complex decongestive treatment, n = 38) and Group 2 (complex decongestive treatment + intermittent pneumatic compression, n = 38). The complex decongestive treatment involved skin care, manual lymphatic drainage, compression bandaging, and exercise for 20 sessions. Group 2 additionally received intermittent pneumatic compression. Main measures: Quantitative outcomes consisted of volumetric measures prior to and after the treatment. Clinical assessments included severity of pain, heaviness and tightness, disability, grip strength, and depression. Results: Lymphoedema was similar at baseline, but treatments significantly reduced the excess volume (from 373 mL to 203 mL in Group 1 and 379.5 mL to 189.5 mL in Group 2). Percentage excess volumes (PEVs) decreased in both groups. The percentage reduction of excess volume was better in Group 2 than Group 1, but the intergroup difference was not significant. The clinical scores reflected improvements, but the heaviness and tightness read significantly lower in Group 2 than Group 1. Conclusion: Intermittent pneumatic compression seems to add no benefit when combined with complex decongestive treatment of lymphoedema, but, may be functional in reducing the sensations of heaviness and tightness for the patients with pitting oedema.

scholarly journals Gastric cancer patients treated by a general or gastric cancer surgical team: a comparative study

2008 ◽  
Vol 45 (1) ◽  
pp. 28-33
Author(s):  
Fernando O. Souza ◽  
Dalnei V. Pereira ◽  
Luís H. Santos ◽  
Luis Antunes ◽  
Juarez Chiesa
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Survival Rates ◽  
University Hospital ◽  
Surgical Team ◽  
Pathologic Features ◽  
Number Of Patients ◽  
Group 2 ◽  
Gastric Cancer Patients ◽  
Group 1

BACKGROUND: Although gastric cancer has been decreasing in incidence in many countries, it is still the second most common cause of cancer deaths worldwide. Its prognosis is poor and depends, among other factors, on early diagnosis as well as on surgeon expertise. AIM: To compare the outcomes of gastric cancer patients treated at a university hospital by a general surgical team and later on by a gastric cancer surgical team. METHODS: Gastric cancer patients were separated into two groups according to whether they were treated by a general surgical team (group 1, n = 136; 1984 to 1993) or by gastric cancer team (group 2, n = 149; 1994 to 2003). Clinical and pathologic features and survival rates were assessed. RESULTS: During a 20-year period, a decreased number of patients underwent surgical resection in the second period (94% vs 86%), a greater number of upper gastrointestinal endoscopies were performed resulting in an increased number of tumors diagnosed as stage I (5% vs 22%). Also, D2 gastrectomies were more frequently performed instead of D0 gastrectomies and negative surgical margins were adequate. Mortality decreased from 9% to 6% in group 1 and 2, respectively and adjuvant therapy has been considered. CONCLUSION: Surgical specialized units for gastric cancer are necessary if better results are to be expected since this approach definitely provides better patient care.

scholarly journals Effect of dietary synbiotic supplementation on serum indoxyl sulfate in prevalent hemodialysis patients

2022 ◽  
Vol 34 (1) ◽  
Author(s):  
Mohamed Saeed Hassan ◽  
Yasser Soliman Ahmed ◽  
Eman Ibrahim Sarhaan ◽  
Nayra Shaker Mehanna ◽  
Norhan Nagdy Madbouli ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Intestinal Flora ◽  
Serum Levels ◽  
Indoxyl Sulfate ◽  
University Hospital ◽  
Blood Levels ◽  
Uremic Toxin ◽  
Cardiovascular Morbidity And Mortality ◽  
Group 2 ◽  
Group 1

Abstract Background Indoxyl sulfate (IS) is produced by action of the intestinal flora on tryptophan in protein diet, and it is normally excreted by the kidney. IS is a protein-bound uremic toxin, and it is difficult to be removed by conventional hemodialysis (HD) methods; so, it accumulates in HD patients and may contribute to major cardiovascular morbidity and mortality. Aim To study the effect of dietary synbiotic (prebiotic and probiotic) supplementation on IS level in prevalent HD patients. Patients and methods This single-blind, placebo-controlled trial was conducted on 80 prevalent HD patients (between January 2017 and March 2017) in Ain Shams University Hospital. Patients were divided into 2 groups: group 1 was given synbiotic (SYN) and group 2 was given placebo for 6 weeks. Blood levels of IS, CRP, creatinine, blood urea nitrogen (BUN), sodium, potassium, calcium, and phosphorus were measured at baseline and after 6 weeks. Results There was a significant reduction in serum IS level in groups 1 and 2 in comparison to their baselines (P value = 0.000 and 0.019 respectively); however, the change in IS level in group 1 after SYN supplementation (64% with IR 72.38–33.33) was more than that shown in group 2 (did not receive SYN) (18.47% with IR 26.75–26.75) with a highly significant P value, 0.000. Also, there were significant reductions in the levels of creatinine, BUN, phosphorus (P values < 0.001), and CRP (P values 0.002) in group 1 respectively with no similar changes noticed in group 2. Conclusion SYN supplementation in HD patients can reduce serum levels of IS and other uremic toxins like BUN and creatinine. Also, it may help to reduce serum phosphorus and CRP levels.

scholarly journals Expectant versus surgical management of incomplete abortions caused by self-intake of abortifacient drugs: results from a randomized controlled trial

2021 ◽  
Vol 10 (6) ◽  
pp. 660
Author(s):  
Ankita Singh ◽  
Devendra Singh Kushwah ◽  
Neha Khatik ◽  
Beenu Kushwah
Keyword(s):  
Success Rate ◽  
Controlled Trial ◽  
Expectant Management ◽  
Successful Outcome ◽  
Controlled Study ◽  
Self Administration ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
Group 2 ◽  
Group 1

Background: Termination of unwanted pregnancies with medical method using recommended protocol based abortifacient drugs is a standard practice followed by obstetricians and gynaecologists worldwide which has a very successful outcome. However, self-administration of these drugs has become rampant because of certain social and practical issues resulting in complications and incomplete abortions as when these drugs are self-administered, recommended protocol is not generally followed. Traditionally incomplete abortions are managed by surgical curettage which itself is associated with procedure related complication and has been challenged by recent studies. Based on these studies many international guidelines have come out in support of expectant management of incomplete abortions. This study compared both of these management protocols to treat incomplete abortions caused by unprescribed intake of abortifacient drugs.Methods: This was a one-year long prospective randomized controlled study in which total 782 females were randomized into two groups of 371 and 411. Group 1 was offered expectant management while group 2 was offered surgical curettage. Results were analysed using appropriate statistical tests.Results: Group 1 showed a success rate of 86% while group 2 showed a success rate of 90% which was comparable. Overall complication rate was found to be higher in Surgical curettage group than in the group which underwent expectant management group.Conclusions: Considering a very high number of patients coming with incomplete abortions caused by self-medication in present practice, expectant management seems to be a safer and more effective method and should be practice more widely.

P–681 Will the hCG trigger dose used for final oocyte maturation in IVF impact endogenous progesterone during the luteal phase? - A randomized controlled trial

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
L Svenstrup ◽  
J Fedder ◽  
S Möller ◽  
D Pedersen ◽  
K Erb ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Luteal Phase ◽  
Controlled Trial ◽  
University Hospital ◽  
Final Oocyte Maturation ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
Significant Difference ◽  
Hcg Trigger ◽  
Group 1

Abstract Study question Is there an association between the hCG dose used for ovulation trigger and the endogenous progesterone production during the luteal phase? Summary answer Increased hCG dosing significantly increased the endogenous progesterone level during the luteal phase. What is known already During the luteal phase of an IVF treatment, the endogenous progesterone (P4) production is negatively impacted due to reduced circulating endogenous LH, caused by negative feed-back of elevated steroids; thus, luteal phase support (LPS) with exogenous P4 remains mandatory in IVF. Apart from inducing final oocyte maturation, the gold standard HCG trigger also functions as an early LPS, boosting P4 production by the corpora lutea (CL). P4 plays a pivotal role for embryo implantation and pregnancy, and an optimal P4 level around peri-implantation seems to be essential for the reproductive outcomes of fresh and frozen/thaw embryo transfer cycles. Study design, size, duration A randomized controlled 4-arm study, including a total of 127 IVF patients, enrolled from January 2015 until September 2019 at the Fertility Clinic, Odense University Hospital, Denmark. Participants/materials, setting, methods IVF patients with ≤ 11 follicles ≥ 12 mm were randomized to four groups. Groups 1–3 were triggered with: 5.000 IU, 6.500 IU or 10.000 IU, hCG, respectively, receiving a LPS consisting of 17-α-hydroxy-progesterone (17α OH P4) to distinguish the endogenous P4 from the exogenous supplementation. Group 4 (control) was randomized to a 6.500 IU hCG trigger and standard LPS. A total of eight blood samples were drawn during the early luteal phase. Main results and the role of chance A total of 94 patients completed the study: 21, 22, 25 and 26 patients in each group, respectively. Baseline characteristics were similar, except for the endogenous LH level and cycle lengths. There were no significant differences between groups regarding ovarian stimulation, number of oocytes and embryos. The median number of follicles ≥ 12mm on the day of trigger was 8.5, resulting in 6.6 oocytes being retrieved. Significant differences in P4 levels were seen at OPU+8 (p &lt; 0.001), OPU+10 (p &lt; 0.001) and OPU+14 (p &lt; 0.001), with positive correlations between P4 level and hCG dose. Groups compared individually showed significant difference in P4 between low and high trigger dose at OPU+4 group 1 and 3 (p = 0.037) and OPU+8 group 1 and 3 (p = 0.007) and between all the three groups around implantation at OPU+6 group 1 and 2 (p = 0.011), group 2 and 3 (p = 0.042) and group 1 and 3 (p &lt; 0.001). Higher P4 levels around implantation were related to follicle count and to pregnancy. After logistic regression analyses there were still significant individual differences between the groups. Limitations, reasons for caution Although patients were randomized and strict inclusion and exclusion criteria were used, the RCT was un-blinded, including a relatively small number of patients. Moreover, for dosing purposes urinary hCG as well as recombinant hCG was used and pharmacokinetics differ. Finally, the P4 level could be influenced by circadian fluctuations. Wider implications of the findings: This is the first study to explore dose-responses in circulating P4 after hCG trigger in IVF patients. Increasing the hCG trigger dose increased the endogenous P4 around peri-implantation. Personalizing the hCG trigger dose could be a key point to secure the most optimal P4 mid-luteal phase P4 level. Trial registration number Eudract 2013–003304–39

scholarly journals The Benign Renal Masses that Were Exposed after Nephron-Sparing Surgery

2021 ◽  
Vol 9 (1) ◽  
pp. 1-8
Author(s):  
Mehmet Balasar ◽  
Serkan Ozkent ◽  
Arif Aydın ◽  
Hakan Hakkı Taşkapu ◽  
Ahmet Atıcı ◽  
...  
Keyword(s):  
Primary Repair ◽  
Nephron Sparing Surgery ◽  
University Hospital ◽  
Tumor Diameter ◽  
Fatty Tissue ◽  
Renal Masses ◽  
Number Of Patients ◽  
Nephron Sparing ◽  
Group 2 ◽  
Group 1

After nephron-sparing surgery (NSS), postsurgical fatty tumor could be mistakenly reported as angiomyolipoma during radiologic imaging of some patients. In the present paper, we studied the postsurgical fatty tumor detected after NSS but not covered before in the literature. In addi-tion, we also evaluated whether the postsurgical fatty tumor was related to the surgical technique employed. Patients admitted to the urology department of our university hospital from 2014 to 2019 and operated with open NSS were evaluated retrospectively. We detected those 156 patients were operated with NSS. Nine patients with angiomyolipoma as primary pathology and four patients with surgical border positivity were excluded from the study. The patients were divided into two groups based on the repair of tumor extraction region. In Group 1, fatty tissue was used for repair, and Group 2 is the primary repair group. In all, 143 patients (Group 1 = 79, and Group 2 = 64) were included in the study. No demographic and radiologic differences, such as number of patients, age, gender, positioning of tumor, mass localization, tumor diameter, and RENAL nephrometry scoring system, were detected between the two groups. Postsurgical fatty tumors were detected in 28 patients in Group 1 and in two patients in Group 2 (P < 0.001). In patients with negative surgical margins after partial nephrectomy, lesions that were radiologically detected mimicking as angiomyolipoma were defined as “postsurgical fatty tumor.” This mass containing adipose tissue only nei-ther depicted vascularization and enhancement nor increase in size for at least 1 year. We assumed that these lesions must be followed as benign lesions not requiring additional treatment.

scholarly journals Veress needle versus direct trocar entry for laparoscopy: a retrospective study

2018 ◽  
Vol 8 (1) ◽  
pp. 127 ◽  
Author(s):  
Sushma Sinha ◽  
Surya Malik
Keyword(s):  
Retrospective Study ◽  
Veress Needle ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Surgical Interventions ◽  
Traditional Technique ◽  
Number Of Patients ◽  
Group 2 ◽  
Needle Entry ◽  
Group 1

Background: The aim of this paper is to compare the outcomes of veress needle entry versus direct trocar for laparoscopy in terms of the duration of the procedure, ease of performance and the complications encountered during each technique.Methods: The present study was conducted on a retrospective basis from April ‘2008 to September 2017, in the dept of Obstetrics and Gynecology, in a 100 bedded hospital, ABGH hospital. All the cases who underwent laparoscopic ligation procedure during this time were taken into account. From 2008 to 2012 traditional technique of veress needle entry was used for access(group -1) but it had been switched over to direct trocar since 2013(group -2) These two groups were compared in terms of the demographic profile, duration of procedure, previous h/o surgical interventions ,ease of performance and various complications encountered during the procedure.Results: The total number of patients who underwent ligation during this period were 1912, which were divided into two groups ,till 2012(veress needle entry group,group-1) 754 patients(39.44%),and after 2012 (direct trocar,group -2) 1158 patients(60.56%).Duration of procedure was 4.5±1.2 min in group 1 which was significantly higher than group 2,2.2±0.8 min(p-value <0.001).Amount of gas required was greater in group 1, 4.9±1.3 lts as compared to group 2,2.4±0.5lts.Conclusions: Direct trocar entry is a reliable alternative to traditional technique for pneumoperitoneum establishment and should be regarded as a part of the surgical armamentarium of a trained laparoscopic surgeon.

scholarly journals Modern approach to combination therapy in patients with pelvic inflammatory diseases

2021 ◽  
Vol 38 (2) ◽  
pp. 45-55
Author(s):  
V. V. Khasanova ◽  
I. I. Kukarskaya ◽  
T. P. Shevlyukova ◽  
E. Yu. Kukarskaya
Keyword(s):  
Inflammatory Diseases ◽  
Reproductive Age ◽  
Vaginal Smear ◽  
Modern Approach ◽  
Basic Therapy ◽  
Number Of Patients ◽  
Complex Therapy ◽  
Group 2 ◽  
Group 1

Objective. The aim of the study was to compare the efficiency of complex therapy of pelvic inflammatory diseases (PID) in patients using the drug Longidaza and the effectiveness of therapy without the use of this drug. Materials and methods. 150 patients of reproductive age with PID. All women underwent basic therapy. The complex treatment of group 1 included the additional drug Longidaza in vaginal suppositories 3000 IU with the general course of 20 injections once every three days. The patients were observed for 60 days. The effectiveness of therapy was determined by the dynamics of diagnostic criteria (clinical and laboratory). Results. During the follow-up period, among patients receiving complex therapy with Longidaza relief of pain syndrome in the lower abdomen was observed much faster, and only 14 (18,5 %) women of group 1 continued to fill it after 2 months of treatment, where as in group 2 60 (81,1 %) patients (p 0,001). Reduction of pain in palpation and cervical traction in patients of the main group was recorded in all (100 %) patients, while in the group of basic therapy this symptom continued to be observed in 23 % of women (p 0.001). The dynamics of decrease in the share of patients with increased uterine size in group 1 was 14.9 % and in group 2 only 8.4 % (p 0.001). In the experimental group, during the 2-month follow-up period, there was observed an increase in the number of patients with a normal number of leukocytes in the vaginal smear by 13 %, while in the second group this parameter increased by only 3 % to the initial value. Conclusions. The results of the research allow indicating the efficiency of treatment of PID when using the drug Longidaza.

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