Prostate cancer-associated thrombotic microangiopathy: A case report and review of the literature

Background: Thrombotic microangiopathy (TMA) is a rare and life-threatening complication of prostate carcinoma. Whether plasma exchange has a role in treatment remains a subject of debate. Here we present a case followed by a systematic review of the literature on this subject. Case report: We describe a 69-year old patient presenting with TMA, which was associated with an underlying metastatic prostate carcinoma. We conducted a search of similar cases in literature. Results: Our patient was treated and responded well on plasma exchange. Systematic review of the literature showed 17 additional cases of TMA associated with prostate carcinoma of which eleven were treated with plasma exchange with mostly good response. Conclusion: Based on current data we cannot exclude a potential role for plasma exchange in prostate cancer associated TMA.

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Fine needle aspiration of metastatic prostate carcinoma simulating a primary adrenal cortical neoplasm: A case report and review of the literature

Diagnostic Cytopathology ◽

10.1002/dc.21165 ◽

2009 ◽

pp. NA-NA

Author(s):

Andrea P. Subhawong ◽

Ty K. Subhawong ◽

Qing Kay Li

Keyword(s):

Case Report ◽

Prostate Carcinoma ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Review Of The Literature ◽

Fine Needle ◽

Metastatic Prostate Carcinoma

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Metastatic prostate carcinoma in head and neck surgery: A Case Report about Prostate Cancer Metastasis in the Thyroid Gland

10.1055/s-0040-1710988 ◽

2020 ◽

Author(s):

Anne-Kathrin Otremba ◽

P Dountsop Yonta ◽

S Kintsler ◽

M Westhofen

Keyword(s):

Prostate Cancer ◽

Case Report ◽

Thyroid Gland ◽

Head And Neck ◽

Prostate Carcinoma ◽

Cancer Metastasis ◽

Neck Surgery ◽

Head And Neck Surgery ◽

Prostate Cancer Metastasis ◽

Metastatic Prostate Carcinoma

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Bendamustine-induced immune hemolytic anemia: a case report and systematic review of the literature

Blood Advances ◽

10.1182/bloodadvances.2020001726 ◽

2020 ◽

Vol 4 (8) ◽

pp. 1756-1759

Author(s):

Maverick Chan ◽

William K. Silverstein ◽

Anna Nikonova ◽

Katerina Pavenski ◽

Lisa K. Hicks

Keyword(s):

Systematic Review ◽

Case Report ◽

Plasma Exchange ◽

Hemolytic Anemia ◽

Autoimmune Hemolytic Anemia ◽

Prior Exposure ◽

Review Of The Literature ◽

Key Points ◽

Immune Hemolytic Anemia

Key Points Bendamustine can cause severe autoimmune hemolytic anemia (AIHA), which may require plasma exchange and aggressive immunosuppression. Bendamustine-induced AIHA can be delayed, and many, but not all, cases report prior exposure to fludarabine.

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Plasma exchange for thrombotic microangiopathy secondary to dermatomyositis associated with acute kidney injury and complement activation: a case report with literature review

Renal Replacement Therapy ◽

10.1186/s41100-019-0244-5 ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Norifumi Hayashi ◽

Keiichirou Okada ◽

Yuko Tsuruyama ◽

Yu Kagaya ◽

Sho Kumano ◽

...

Keyword(s):

Acute Kidney Injury ◽

Intensive Care ◽

Case Report ◽

Plasma Exchange ◽

Complement Activation ◽

Thrombotic Microangiopathy ◽

Kidney Injury ◽

Ivig Therapy ◽

Case Presentation ◽

Life Threatening

Abstract Background Thrombotic microangiopathy (TMA) in patients with connective tissue disease is rare but life-threatening. In particular, the survival rate of patients with dermatomyositis (DM) that develop TMA is low. The effectiveness of plasma exchange (PEX) therapy is unclear for the treatment of TMA secondary to DM. Case presentation We describe a case of a 28-year-old woman who developed severe DM complicated by aspiration pneumonia from dysphagia and acute kidney injury. The patient was unresponsive to corticosteroids and intravenous immunoglobulin (IVIG) therapy and developed TMA. In this case, immunofluorescence of skin biopsy revealed that complement activation was involved in the pathogenesis of DM. After 6 PEX therapies, thrombocytopenia improved. She was successfully treated by intensive care and PEX therapy. Conclusions PEX therapy was effective to treat TMA secondary to DM associated with complement activation.

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Oncogenic Osteomalacia Associated with Metastatic Prostate Carcinoma: Case Report and Review of the Literature

Journal of the American Geriatrics Society ◽

10.1111/j.1532-5415.1993.tb06765.x ◽

1993 ◽

Vol 41 (9) ◽

pp. 983-985 ◽

Cited By ~ 18

Author(s):

Cynthia T. McMurtry ◽

Michael Godschalk ◽

Hartmut H. Malluche ◽

Zhaopo Geng ◽

Robert A. Adler

Keyword(s):

Case Report ◽

Prostate Carcinoma ◽

Review Of The Literature ◽

Oncogenic Osteomalacia ◽

Metastatic Prostate Carcinoma

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Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis – case report and systematic review of dabigatran use

VASA ◽

10.1024/0301-1526/a000876 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Marina Di Pilla ◽

Stefano Barco ◽

Clara Sacco ◽

Giovanni Barosi ◽

Corrado Lodigiani

Keyword(s):

Systematic Review ◽

Case Report ◽

Lower Limb ◽

Limb Ischemia ◽

Acute Limb Ischemia ◽

Review Of The Literature ◽

Heparin Induced Thrombocytopenia ◽

Lower Limb Ischemia ◽

Vein Thrombosis ◽

Left Lower Limb

Summary: A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT.

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