The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

Abstract Background: Although it has already been reported that chronic liver disease (CLD) can induce sarcopenia, the impact of sarcopenia, especially on motor function, in older patients with CLD is still unclear. Therefore, we investigated the effects of liver fibrosis on motor function in these patients.Methods: In all, 117 older patients with CLD aged above 60 years (men, n=70; women, n=47) were included in this study. We examined the presence or absence of sarcopenia and checked motor functions such as muscle strength and walking speed. The results were compared between patients with FIB-4 index of >3.25, indicative of severe-degree liver fibrosis (SLF), and those with an index of <3.25, indicative of low-degree liver fibrosis (LLF). We also analyzed the factors related to the decrease in gait speed.Results: The decrease in gait speed (<1.0 m/s) was significantly higher (P = 0.027) and the knee extension force (KEF) was significantly lower (P = 0.010) in men with SLF than in those with LLF. In this study, liver fibrosis (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.56–0.90) and KEF (OR = 1.09, 95% CI = 1.02–1.16) were identified as factors associated with the decrease in gait speed.Conclusions: Older male patients with CLD have decreased motor function as the disease progresses. We found that the decrease in gait speed is related to liver fibrosis and KEF. It is necessary to focus on the motor function of older patients with CLD, especially the gait speed.

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The relationship between amino acid-nitrogen metabolism and plasma zinc in patients with chronic liver disease.

Kanzo ◽

10.2957/kanzo.42.120 ◽

2001 ◽

Vol 42 (3) ◽

pp. 120-125 ◽

Cited By ~ 2

Author(s):

Kazuhiro KATAYAMA ◽

Yuko OOKA ◽

Sumi KIKKAWA ◽

Akio UEMURA ◽

Shinichiro SHINZAKI ◽

...

Keyword(s):

Liver Disease ◽

Amino Acid ◽

Chronic Liver Disease ◽

Nitrogen Metabolism ◽

Chronic Liver ◽

Plasma Zinc ◽

Amino Acid Nitrogen ◽

The Relationship

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The relationship between cardiac and liver iron evaluated by MR imaging in haematological malignancies and chronic liver disease

Blood Cancer Journal ◽

10.1038/bcj.2011.48 ◽

2012 ◽

Vol 2 (1) ◽

pp. e49-e49 ◽

Cited By ~ 9

Author(s):

J M Virtanen ◽

K J Remes ◽

M A Itälä-Remes ◽

J P Saunavaara ◽

M E Komu ◽

...

Keyword(s):

Liver Disease ◽

Mr Imaging ◽

Chronic Liver Disease ◽

Chronic Liver ◽

Haematological Malignancies ◽

Liver Iron ◽

The Relationship

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The relationship between the intracellular redox status of immune cells and progression of hepatitis C virus related chronic liver disease

Japanese Journal of Clinical Immunology ◽

10.2177/jsci.27.315 ◽

2004 ◽

Vol 27 (5) ◽

pp. 315-321 ◽

Cited By ~ 1

Author(s):

Hiroshi ONODA ◽

Hiroki TAKAHASHI ◽

Masahisa OSADA ◽

Akira SAITO ◽

Mikio ZENIYA ◽

...

Keyword(s):

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Chronic Liver Disease ◽

Immune Cells ◽

Redox Status ◽

Chronic Liver ◽

The Relationship ◽

Intracellular Redox Status ◽

Intracellular Redox

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Correlation of Trace Elements in Patients of Chronic Liver Disease with Respect to Child- Turcotte- Pugh Scoring System

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2017/26519.10655 ◽

2017 ◽

Cited By ~ 2

Author(s):

Amit Agarwal

Keyword(s):

Trace Elements ◽

Liver Disease ◽

Chronic Liver Disease ◽

Scoring System ◽

Chronic Liver

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TRACE ELEMENTS IN PLASMA AND NUTRITIONAL ASSESSMENT IN PATIENTS WITH COMPENSATED CIRRHOSIS ON A LIVER TRANSPLANT LIST

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032016000200006 ◽

2016 ◽

Vol 53 (2) ◽

pp. 84-88 ◽

Cited By ~ 4

Author(s):

Thays Santana GUERRA ◽

Nelci Fenalt HOEHR ◽

Ilka de Fátima Santana Ferreira BOIN ◽

Raquel Silveira Bello STUCCHI

Keyword(s):

Trace Elements ◽

Liver Disease ◽

Nutritional Status ◽

Liver Transplant ◽

Trace Element ◽

Chronic Liver Disease ◽

Disease Severity ◽

Nutritional Assessment ◽

Chronic Liver ◽

Low Levels

ABSTRACT Background - In chronic liver disease, trace element levels in plasma are usually low. However, the specific cause and functional implications of this abnormality are yet not well understood. These element levels may decrease as a result of abnormal liver function in patients with cirrhosis and/or malnutrition. Objective - To evaluate the nutritional status and the profile of trace elements in plasma of patients with cirrhosis on a liver transplant list and to correlate them with disease severity. Methods - This cross-sectional study evaluated 31 male patients diagnosed with compensated liver cirrhosis on a waiting list for liver transplant. Nutritional status was objectively evaluated through anthropometry using Mendenhall score and Blackburn classification, subjectively through the Detsky questionnaire and severity of the disease by MELD and CTP score. Trace elements (Zn, Se, Cu, Ca, Fe, Mg and Mn) in plasma were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Statistical analysis was performed using Mann-Whitney test. Results - According to the nutritional assessment 19 (61.3%) were malnourished and 12 (38.7%) were overweight. Regarding disease severity 12 (39%) were classified as Child A, 17 (55%), Child B and 2 (6%) Child C, with 46.9% of patients with MELD score >17. The trace element analysis indicated that 31 (100%) had Mn levels above the reference range, 23 (74.2%) low levels of Cu, 29 (93.5%) with deficiency of Se, and 31 (100%) low levels of Ca and Mg. Disease severity did not show statistical difference between the studied trace elements, in contrast to the nutritional status, in which the malnourished group showed higher levels of Mn (P=0.01) and Fe (P=0.01) and low levels of Zn (P=0.03) when compared to the overweight group. Conclusion - The results showed that the trace elements in plasma are altered in chronic liver disease; without significant correlation to disease severity, but correlated to nutritional status. Malnutrition is present in the patients studied, nonetheless a new scenario with an increase in the prevalence of overweight was verified regardless of the degree of hepatic decompensation.

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The Relationship between Hepatic Myeloid-Derived Suppressor Cells and Clinicopathological Parameters in Patients with Chronic Liver Disease

BioMed Research International ◽

10.1155/2021/6612477 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Zhijia Zhou ◽

Penghua Lai ◽

Shaoliang Zhang ◽

Yujie Wang ◽

Ning Qu ◽

...

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Clinical Characteristics ◽

Suppressor Cells ◽

Chronic Liver ◽

Clinicopathological Parameters ◽

Myeloid Derived Suppressor Cells ◽

Liver Inflammation ◽

The Difference ◽

The Relationship

Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy controls to investigate the expression of MDSCs, and the relationships between the expression of hepatic MDSCs and the clinical characteristics were analyzed. We found that the expression of CD11b+CD33+ MDSCs is closely related to chronic liver disease and positively correlated with clinical parameters such as ALT, AST, and globulin. Ultimately, the present study suggests that hepatic CD11b+CD33+ MDSCs are increased in HCC and AIH and positively correlate with the liver stages of hepatitis activity and liver fibrosis stage.

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Effects of a Preparation Containing a Standardized Ginseng Extract Combined with Trace Elements and Multivitamins against Hepatotoxin-induced Chronic Liver Disease in the Elderly

Journal of International Medical Research ◽

10.1177/030006058701500503 ◽

1987 ◽

Vol 15 (5) ◽

pp. 276-281 ◽

Cited By ~ 13

Author(s):

M. Zuin ◽

P. M. Battezzati ◽

M. Camisasca ◽

D. Riebenfeld ◽

M. Podda

Keyword(s):

Trace Elements ◽

Liver Disease ◽

Chronic Liver Disease ◽

The Elderly ◽

Chronic Liver ◽

Ginseng Extract ◽

Significant Difference ◽

Before And After ◽

Pre Treatment

A preparation containing a standardized ginseng extract which has been shown to exert anti-hepatotoxic activity in vitro, combined with trace elements and multi-vitamins was compared to placebo in 24 elderly out-patients with toxin-induced (alcohol and drugs) chronic liver disease in order to evaluate its effect on liver function. Each patient was blindly treated either with the preparation containing ginseng extract or placebo for 12 weeks. The preparation containing ginseng extract significantly modified bromsulphthalein retention and blood zinc levels when compared to pre-treatment levels and to placebo. Serum bile acids, and γ-glutamyl transpeptidase before and after a fatty meal were significantly reduced after treatment with the test preparation and not with placebo. When the two treatment groups were compared, however, no significant difference in these parameters was observed. These results suggest that treatment with the preparation containing ginseng extract could improve the detoxifying activity of the liver in elderly patients with toxin-induced chronic liver disease.

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Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease

Biomolecules ◽

10.3390/biom11121808 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1808

Author(s):

David Marti-Aguado ◽

Matías Fernández-Patón ◽

Clara Alfaro-Cervello ◽

Claudia Mestre-Alagarda ◽

Mónica Bauza ◽

...

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Digital Pathology ◽

Scoring Systems ◽

Chronic Liver ◽

Research Network ◽

Histological Evaluation ◽

Nonalcoholic Fatty Liver ◽

Metavir Score ◽

The Relationship

Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-score: proportionate area of staining intensities clusters) measurements were independently performed. Our data show that I-scores and C-scores increase with inflammation grades (p < 0.001). High correlation was seen for CH (ρ = 0.85–0.88), but only moderate for NAFLD (ρ = 0.5–0.53). I-score (p = 0.008) and C-score (p = 0.002) were higher for CH than NAFLD. Our MATLAB algorithm performed better than QuPath software for the diagnosis of low-moderate inflammation (p < 0.05). C-score AUC for classifying NASH was 0.75 (95%CI, 0.65–0.84) and for moderate/severe CH was 0.99 (95%CI, 0.97–1.00). Digital pathology measurements increased with fibrosis stages (p < 0.001). In conclusion, quantitative and morphometric metrics of inflammatory burden obtained by digital pathology correlate well with pathologists’ scores, showing a higher accuracy for the evaluation of CH than NAFLD.

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