Synthesis of fused dihydrobenzo [4,5]imidazo[1,2-a]pyrmido[5,4-e]pyrmidin-3(4H)-amine derivatives

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Hamid Mohammed ◽  
Fadhel R. Hafedh ◽  
Zainab N. Mageed
Keyword(s):  
Acetic Anhydride ◽  
Physical Properties ◽  
Aliphatic Amines ◽  
Methyl Amine ◽  
Ft Ir ◽  
Ethyl Amine ◽  
Reaction Compound

Abstract   Some of fused dihydrobenzo [4,5]imidazo [1,2-a] pyrmido [5,4-e] pyrmidin-3(4H)-amine  derivatives were synthesized,  theses derivatives derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4,5), which prepared by reaction 1H-benzimidazol-2-amine (1) and p-chlorobenzaldehyde or p-bromobenzaldehyde (2)  and malononitrile (3). These derivatives prepared by reaction compound (4,5) with with triethylorthoformate in presence acetic anhydride to give the products (6,7), then the products was reacted with aliphatic amines (hydrazine, methyl amine, ethyl amine, propyl amine and isobutyl amine) to give pyrmidin rings (8-17) respectively. All these derivatives characterization by FT-IR , HNMR spectra and physical properties.

scholarly journals Synthesis and Characterization of New heterocyclic Polyacrylamides from Derivatives 2-Aminobenzothiazole

2014 ◽  
Vol 11 (2) ◽  
pp. 407-418
Author(s):  
Baghdad Science Journal
Keyword(s):  
Physical Properties ◽  
1H Nmr ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Ft Ir ◽  
Ethyl Amine ◽  
Structure Confirmation

The present work involved preparation of new hetro cyclic polyacrylamides (1-9) using reaction of polyacryloyl chloride with 2-aminobenzothiazole which prepeard by thiocyanogen method in the presence of a suitable solvent and amount tri ethyl amine (Et3N) with heating. The structure confirmation of polymers were proved using FT-IR,1H-NMR,C13NMR and UV spectroscopy.Other physical properties including softening and melting points, and solubility of the polymers were also measured.

Chemical and Physical Properties of FSC Cigarette Papers and Physical Properties of the Cigarettes They Were Taken From: Results From a Small Product Survey of Cigarette Brand-Styles Sold in the USA

2018 ◽  
Author(s):  
John Lauterbach
Keyword(s):  
Physical Properties ◽  
Cigarette Brand ◽  
The Usa ◽  
Physical Tests ◽  
Ft Ir ◽  
Small Product

We undertook a small product survey in which we purchased a range of brand-styles at retail and sent them to commercial laboratories for dimensional and physical tests, including banded and nonbanded area porosities. Other analyses obtained used chemical, chromatographic, and spectrophotometric (FT-IR) techniques to identify main banding agents and additives used with them. One finding from this study was at least at the time the samples were collected, some companies used just one FSC paper for all products while others used multiple FSC papers.<br>

Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization

2019 ◽  
Vol 16 (6) ◽  
pp. 511-516
Author(s):  
Adnan Cetin
Keyword(s):  
13C Nmr ◽  
Cyclization Reaction ◽  
Electrophilic Cyclization ◽  
Pyrazole Derivatives ◽  
Spectral Analyses ◽  
Mass Spectral ◽  
Palladium Catalyzed ◽  
Ft Ir ◽  
Reaction Compound

Efficient steps towards the synthesis of novel (phenyl)(1&#039;-aryl-1,5,5&#039;-triphenyl[3,3&#039;-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of &#945;,&#946;-acetylenic hydrazones E-3a-e and copper(I) iodide. All synthesized compounds were characterized by FT-IR, 1H, 13C NMR and Mass spectral analyses.

scholarly journals Friedel-Crafts Acylation of Furan: Development of A Green Process Using Chromium-exchanged Dodecatungstophosphoric Acid: Effect of Support, Mechanism and Kinetic Modelling

2021 ◽  
Author(s):  
Deepak S. Desai ◽  
Ganapati D. Yadav
Keyword(s):  
Acetic Anhydride ◽  
Kinetic Modelling ◽  
Incipient Wetness Impregnation ◽  
Impregnation Method ◽  
Support Mechanism ◽  
Full Characterization ◽  
Prior Art ◽  
Acid Effect ◽  
Ft Ir ◽  
Effect Of Support

Abstract The Friedel-Crafts acylation of furan with acetic anhydride to produce 2-acyl furan is industrially important. With an aim of replacing the highly polluting process, it this study, supported but modified heteropoly acids were used. Metal exchanged dodecatungstophosphoric acid (DTP) was loaded on three different supports and its effect on acylation was evaluated. Thus, chromium exchanged DTP was supported on K-10, SiO2, and ZrO2 using the incipient wetness impregnation method. 20% w/w Cr0.66-DTP/K-10 having the best activity for the acylation of furan with acetic anhydride was chosen for full characterization and reaction kinetics. Under optimized condition, the catalyst to furan ratio was 9.6%, significantly less as per prior art, which gave 88% conversion with 100% selectivity. The prepared catalysts were characterized by sophisticated techniques, namely, XRD, FT-IR, SEM, NH3-TPD, TGA, and BET. The Eley-Rideal mechanism was found to fit the kinetic data. The activation energy was found to be 18.03 kcal/mol. The reaction is green and clean as no chlorinated chemicals, reagents, and catalysts were used.

scholarly journals Preparation and Identification of Novel 1, 3-Oxazepine Derivatives by Cycloaddition Reactions [2+5] of Selected Carboxylic Acid Anhydrides with Imines Derived from 4-methyl aniline

2018 ◽  
Vol 29 (2) ◽  
pp. 93 ◽  
Author(s):  
Obaid H. Abid ◽  
Ahmed Khames Ramadan
Keyword(s):  
Carboxylic Acid ◽  
Physical Properties ◽  
Spectral Data ◽  
1H Nmr ◽  
Cycloaddition Reaction ◽  
Absolute Ethanol ◽  
Cycloaddition Reactions ◽  
Thermal Condensation ◽  
Ft Ir ◽  
Acid Anhydrides

Novel 1,3-oxazepine derivatives have been synthesis via (2+5) cycloaddition reaction of imines and selected cyclic carboxylic acid anhydrides by refluxing in dry benzene. Imines have been prepared by thermal condensation of 4-methyl aniline and para substituted benzaldehyde in absolute ethanol under reflux conditions. The structure of the target compounds were Identified by some physical properties and spectral data of FT-IR and 1H-NMR.

The Effect of Solvent Polarity on Phase Transformation of Citrogypsum via Hydrothermal Process

2019 ◽  
Vol 803 ◽  
pp. 351-355 ◽  
Author(s):  
Thanakit Sirimahasal ◽  
Yutthana Kalhong ◽  
Lida Simasatitkul ◽  
Siriporn Pranee ◽  
Samitthichai Seeyangnok
Keyword(s):  
Physical Properties ◽  
Calcium Sulfate ◽  
Hydrothermal Process ◽  
Solvent Polarity ◽  
Sem Images ◽  
Crystal Water ◽  
Calcium Sulfate Dihydrate ◽  
Hexagonal Shape ◽  
Ft Ir ◽  
Hexane Solution

Calcium sulfate dihydrate (CaSO4•2H2O, CSD), gypsum is a by-product in the production of citric acid (citryogypsum). This by-product could neither be exploited nor distributed as a reactant because of its physical properties including those that are not equivalent to natural gypsum. Moreover, the mentioned citrogypsum has been continually increasing environmental problems. Therefore, this research aims at how to recycle gypsum that is synthesized by hydrothermal method at 95oC for 7 hrs under the atmospheric pressure via different solutions (MeOH, EtOH, PrOH, BuOH and Hexane). In order to produce alpha-calcium sulfate hemihydrate (α-CaSO4•0.5H2O, α-CSH) with improved physical properties that will be used for different industries. FT-IR reveals the chemical composition of crystal and the adsorption of methyl group on the surface. Besides, TGA thermogram shows the theoretical crystal water content of CSD and α-CSH 20.9 wt% and 6.2 wt% respectively. The DSC thermogram, shows that endothermic peaks at 151.2 oC and 168.5 oC. There were two steps of loss at 1.5 and 0.5 water molecule respectively. With SEM images of crystal shows the plate-like shape of citrogypsum, while α-CSH shows the hexagonal shape excluding hexane solution. Of all the results, the polarity of solution has an impact on the transition of CSD to α-CSH under this condition.

Effect of Heat-Treatment Temperature on the Osteoconductivity of the Apatite Derived from Bovine Bone

2006 ◽  
Vol 309-311 ◽  
pp. 41-44 ◽  
Author(s):  
Sang Hoon Rhee ◽  
Ho Nam Park ◽  
Yang Jo Seol ◽  
Chong Pyong Chung ◽  
Sang Hyuk Han
Keyword(s):  
Heat Treatment ◽  
Physical Properties ◽  
Heat Treatment Temperature ◽  
Zealand White Rabbit ◽  
Treatment Temperature ◽  
Bovine Bone ◽  
Carbonate Ions ◽  
Heat Treated ◽  
Ft Ir ◽  
Field Emission Electron Microscopy

Effect of heat-treatment temperature on the osteoconductivity of the apatite derived from bovine trabecular bone was investigated. Three different heat-treatment temperatures (600, 800 and 1000 oC) were adopted in the experiment and their effects on the physical properties of apatite granules, which could affect on the osteoconductivity, were evaluated. The content of carbonate ions in the apatite structure was assessed by FT-IR and its crystallinity was evaluated by X-ray diffractometry. The microstructure was assessed by field emission electron microscopy. Apatite granules heat-treated at 600 oC and 1000 oC were implanted into the calvaria of New Zealand White rabbit for 4 weeks, respectively, and the undecalcified ground histologic specimens stained with multiple staining method was observed. As increasing the heat-treatment temperature, the crystal size and crystallinity of the apatite increased while the content of carbonate ions decreased. The apatite granules heat-treated at 600 oC showed much better osteoconductivity comparing to that heat-treated at 1000 oC. The results were explained in terms of the physical properties of apatite which could affect to the osteoconductivity.

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