scholarly journals Rare case of Visceral form of Infectious Mononucleosis in Irkutsk Region

2019 ◽  
Vol 3 (6) ◽  
pp. 164-167
Author(s):  
N. K. Bobrova ◽  
E. Yu. Zorkaltseva
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Hypochromic Anemia ◽  
Symptomatic Treatment ◽  
Neural System ◽  
Unknown Etiology ◽  
Barr Virus ◽  
Leading Role ◽  
Epstein Barr

Infectious mononucleosis (MI) is caused by the Herpes viridae family of viruses. Currently, most researchers assign a leading role to the Epstein-Barr virus. In present time there are no unified clinical classification of infection mononucleosis, but many authors recognize the visceral form which involves cardiovascular system, adrenal glands, lungs, central neural system and others organs. The article describes a clinical case of MI in the 28-year-old patient. She applied for medical help with complaints of fever up to 39 °C, weakness in the legs and arms, weight loss and received symptomatic treatment on an outpatient department. After 2 months on the background of deterioration, she was hospitalized in an infectious diseases hospital with severe symptoms of intoxication, lymphoproliferative syndrome, myocarditis, pericarditis, hepatitis, polyneuropathy with quadriparesis, hypochromic anemia, thrombocytopenia. She was consulted by an oncologist and diagnosed with cervical cancer. Laboratory confirmation was obtained – Epstein-Barr virus was detected in the blood. Against the background of antiviral therapy, a regression of clinical symptoms was achieved in a week. The patient was transferred to a oncological hospital. It is recommended to examine patients with high fever of unknown etiology on myocardial infarction for the timely appointed etiotropic therapy.

scholarly journals ESTIMATION OF EFFICIENCY OF VARIOUS SCHEMES OF THERAPY OF PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN – BARR

2019 ◽  
pp. 41-45
Author(s):  
K. V. Yurko ◽  
V. M. Kozko ◽  
N. F. Merkulova ◽  
О. I. Моhylenets
Keyword(s):  
Blood Serum ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Positive Impact ◽  
Blood Analysis ◽  
Barr Virus ◽  
National Medical ◽  
Complex Therapy ◽  
Epstein Barr

Background: Actuality of study of infectious mononucleosis (ІМ) is conditioned by high infected of population by the Epstein – Barr virus (EBV), specific virus affinity to the immunocompetent cells, lifelong virus persistence in an organism and often latent process. Methods: Research on the work topic was conducted at the Department of Infectious Diseases of Kharkiv National Medical University. A total of 45 patients with IM (26 men and 19 women) who were hospitalized at the Regional Clinical Hospital in 2018–2019 years were surveyed. The vast majority of patients with IM were young people aged from 18 to 25, of whom 597 % were students. Results: The clinical picture of infectious mononucleosis caused by the Epstein–Barr virus, mainly characterized by manifestations of hepatomegaly, lymphadenopathy, intoxication syndrome and nasopharyngeal tonsillitis. The efficacy of combined use of Valacyclovir and Nuclex in complex therapy of patients with infectious mononucleosis caused by Epstein – Barr virus (EBV) was studied. The use of such therapy was found to promotes regression of clinical symptoms, contribute to normalization of indices of clinical blood tests and lead to a decrease of the number of EVB's DNA copies in the blood serum or complete elimination of virus. Conclusions: Thus, evaluation of the effectiveness of the use of valacyclovir and nuclex in the complex therapy of patients with infectious mononucleosis caused by Epstein–Barr virus, indicates a more significant regression of clinical symptoms, significantly more pronounced positive impact on the indicators of clinical blood analysis and the number of copies of EBV DNA in blood serum than in the comparison group. Obtained results allowed to substantiate the use of complex therapy of valacyclovir and nuclex in patients with IM caused by EBV.

Epstein-Barr virus reactivation induced myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis

2021 ◽  
Vol 14 (10) ◽  
pp. e245059
Author(s):  
Timothy Philip Noonan ◽  
Konstantin N Konstantinov ◽  
Leonor Echevarria
Keyword(s):  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Antiviral Treatment ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Reactive Lymphoid Hyperplasia ◽  
Virus Reactivation ◽  
Barr Virus ◽  
Facial Swelling ◽  
Epstein Barr

We present a patient with systemic symptoms including 4 months of dyspnoea worsened with exertion, fatigue, rhinorrhoea, intermittent facial swelling, generalised lymphadenopathy and weight loss. Laboratory studies demonstrated proteinuria and eosinophilia. His serology was consistent with Epstein-Barr Virus (EBV) reactivation. A lymph node biopsy was consistent with EBV-associated reactive lymphoid hyperplasia. He was told to continue symptomatic treatment for EBV infection. After several admissions, vasculitis workup and myeloperoxidase-antineutrophil cytoplasmic autoantibody (ANCA) studies were positive. Evolution of clinical symptoms, laboratory parameters and our literature review suggested the diagnosis of EBV-associated ANCA vasculitis. Steroids were started after the patient continued to deteriorate; the viral load started increasing, so we added valganciclovir with favourable clinical response and no relapse during the follow-up for 6 months. This suggests that with evidence of viraemia (primary or reactivation), antiviral treatment likely has clinical benefit while immunosuppression is being considered.

scholarly journals Principles of the treatment of chronic Epstein–Barr virus infection and associated diseases

2019 ◽  
Vol 64 (2) ◽  
pp. 38-46
Author(s):  
S. A. Yakushyna ◽  
L. B. Kisteneva ◽  
S. G. Cheshyk
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Nucleoside Analogs ◽  
Chronic Fatigue ◽  
The Body ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Associated Diseases ◽  
Epstein Barr

Epstein – Barr virus, related to herpes viruses, causes infectious mononucleosis during the initial infection; after recovery, the virus persists in the body throughout lifetime. The presence of clinical symptoms and viral load in a patient in 6 months after the infectious mononucleosis disease indicates the formation of chronic active Epstein – Barr viral infection. Hemophagocytic lymphohistiocytosis, posttransplantation lymphoproliferative disease and chronic fatigue syndrome, which has a polyetiological nature, are also associated with the activation of the persistent Epstein – Barr virus. Most of these diseases develop in children due to their physiological immunodeficiency and are accompanied by high mortality – up to 50%. Immune mechanisms, in addition to the virus itself, play a leading role in the pathogenesis of the diseases. The article summarizes all existing approaches to the treatment of chronic Epstein – Barr virus-associated diseases. The authors have analyzed the effectiveness of these approaches on the basis of various published studies. These diseases are treated with etiotropic antiviral drugs – nucleoside analogs, nonspecific immunotherapy, targeted therapy with monoclonal antibody preparations, immune cellular CD8+ therapy. In case of ineffectiveness of these methods, the alternative bone marrow transplantation is used. The article highlightes promising areas for the development of new approaches to the treatment of Epstein – Barr virus-associated diseases.

scholarly journals Analysis of common causes of liver damage among children 12 years and younger in Weifang

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110066
Author(s):  
Qinghong Meng ◽  
Na Li ◽  
Lianmei Yuan ◽  
Xiaona Gao
Keyword(s):  
Liver Damage ◽  
Epstein Barr Virus ◽  
Metabolic Diseases ◽  
Unknown Etiology ◽  
Severe Liver ◽  
Drug Induced ◽  
Barr Virus ◽  
Common Causes ◽  
Severe Liver Damage ◽  
Epstein Barr

Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most common causes of infectious liver damage were viral infection (1515 cases), Mycoplasma pneumoniae infection (343 cases), and bacterial infection (197 cases). The most common causes of viral liver damage were Epstein–Barr virus, cytomegalovirus, and enterovirus. The most common causes of non-infectious liver damage were drug-induced liver damage, Kawasaki disease, and genetic metabolic diseases. There were 31 cases of severe liver damage. Conclusion There were many causes of liver damage among children in Weifang. Infections, and especially viral infections such as Epstein–Barr virus, were the most common causes of liver damage. Severe liver damage was primarily caused by drugs or poisons.

Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants

2010 ◽  
Vol 52 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Sumitaka Dohno ◽  
Akihiko Maeda ◽  
Yoshihito Ishiura ◽  
Tetsuya Sato ◽  
Mikiya Fujieda ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Acute Acalculous Cholecystitis Due to a Primary Epstein Barr Virus Infection in a Pediatric Patient

2021 ◽  
Vol 13 (1) ◽  
pp. 86-90
Author(s):  
Carlos Leganés Villanueva ◽  
Ilaria Goruppi ◽  
Nuria Brun Lozano ◽  
Federica Bianchi ◽  
María Quinteiro González ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Acute Complications ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Human Viruses

Epstein–Barr virus (EBV) is estimated to infect more than 98% of adults worldwide and is one of the most common human viruses. Acute acalculous cholecystitis (AAC) of the gallbladder is an atypical complication of infectious mononucleosis caused by EBV. Conservative management has been described in the context of AAC caused by EBV. A surgical approach must be considered in the case of acute complications such as perforation or gallbladder gangrene. We present the case of a 10-year-old female patient with AAC due to infectious mononucleosis syndrome caused by primary EBV infection.

Epstein-Barr Virus Is Not Synonymous With Infectious Mononucleosis

PEDIATRICS ◽  
1978 ◽  
Vol 61 (3) ◽  
pp. 506-506
Author(s):  
Alex J. Steigman
Keyword(s):  
Infectious Mononucleosis ◽  
Primary Infection ◽  
Epstein Barr Virus ◽  
Clinical Syndrome ◽  
Barr Virus ◽  
Clinical Responses ◽  
Epstein Barr ◽  
Uncertain Etiology

Infectious mononucleosis (IM) is a defined clinical syndrome, until recently regarded as of uncertain etiology affecting only a limited number of persons. The etiology of IM can now be ascribed correctly to primary infection with Epstein-Barr virus (EBV), a member of the herpesvirus family. It is increasingly evident that primary infection with EBV may also induce a range of clinical responses from no detectable illness1 to a variety of disorders without the clinical or hematologic hallmarks of the IM syndrome.

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