scholarly journals A case of hepatocellular carcinoma with bone scintigraphy negative disseminated bone marrow metastasis diagnosed by bone marrow aspiration

Kanzo ◽  
2014 ◽  
Vol 55 (12) ◽  
pp. 740-748
Author(s):  
Kazuhiko Koike ◽  
Mariko Itsubo ◽  
Hisao Tajiri
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bone Marrow ◽  
Bone Scintigraphy ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Metastasis

Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis

2019 ◽  
Vol 105 (5) ◽  
pp. 388-393
Author(s):  
Di Wang ◽  
Yang Luo ◽  
Di Shen ◽  
Lin Yang ◽  
Hui-Ying Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lung Adenocarcinoma ◽  
Survival Time ◽  
Kinase Inhibitor ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Best Supportive Care ◽  
Bone Marrow Metastasis ◽  
Platinum Based Chemotherapy ◽  
Targeted Drug

Background: Bone marrow metastasis occurs in lung adenocarcinoma patients with a poor prognosis due to the late course and lack of definitive treatments, although reports on this are limited. This study analyzed the clinical manifestation, laboratory examination, treatment, and prognosis of patients with lung adenocarcinoma with bone marrow metastasis. Methods: All patients were confirmed to have bone marrow infiltration by bone marrow aspiration. The clinical data of 12 patients with lung adenocarcinoma with bone marrow metastasis were analyzed retrospectively. The prognostic factors were analyzed by Kaplan-Meier statistics. Results: The common biomarker abnormalities in 12 patients were elevated carcinoembryonic antigen in 12 cases (100%), elevated lactate dehydrogenase in 9 cases (75%), increased alkaline phosphatase and anemia in 8 cases each (66.7%), and thrombocytopenia in 4 cases (33.3%). After diagnosis of bone marrow metastasis, 5 patients were treated with platinum-based chemotherapy, 3 patients received chemotherapy and targeted drug tyrosine kinase inhibitor (TKI) therapy, 2 patients received simple TKI therapy, and 2 patients received only best supportive care (BSC) therapy. The median duration of survival after the diagnosis of bone marrow involvement was 422 days. The survival time of patients receiving TKI therapy after bone marrow metastasis was significantly better than that of patients receiving only BSC and chemotherapy (χ2=4.636, P=0.031). Conclusions: The survival period of patients with lung adenocarcinoma with bone marrow metastasis is short, and targeted drug TKI treatment can prolong the survival time for patients with EGFR mutation–carrying lung adenocarcinoma with bone marrow metastasis.

scholarly journals Bone marrow involvement as a rare manifestation of relapsed choroidal melanoma

2020 ◽  
Vol 8 (8) ◽  
pp. 3110
Author(s):  
Nusrat Bashir ◽  
Farzana Manzoor ◽  
Bilal Musharaf ◽  
Ruby Reshi
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Choroidal Melanoma ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Metastasis ◽  
Common Site ◽  
Immune Histochemistry ◽  
Rare Manifestation ◽  
Disseminated Disease

Choroidal Melanoma is the most common primary intra-ocular malignancy. Incidence of primary choroidal melanoma is about 6 cases per 1 million population. It disseminates hematogenously. The most common site of metastasis is liver. Metastatic melanoma involving the bone marrow is rare, occurring in 5% of patients with disseminated disease. However, Choroid melanoma with bone marrow involvement is very rare. Only a few case reports are published in literature.  Authors present a case of bone marrow metastasis from choroid melanoma in 55 years old female who has been treated for primary choroidal melanoma by enucleation of left eye three years back. In the evaluation of symptomatic anemia, features suggestive of bone marrow infiltration by choroidal melanoma were observed on bone marrow aspiration and biopsy. The diagnosis was confirmed by positivity of immune-histochemistry markers HMB-45 and Melana.

scholarly journals Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma

2016 ◽  
Vol 22 (2) ◽  
pp. 267-271 ◽  
Author(s):  
Young Mi Hong ◽  
Ki Tae Yoon ◽  
Mong Cho ◽  
Dae Hwan Kang ◽  
Hyung Wook Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bone Marrow ◽  
Bone Marrow Metastasis

scholarly journals Bone marrow metastasis of glioblastoma multiforme mimicking acute myeloid leukemia

2020 ◽  
Vol 2020 (6) ◽  
Author(s):  
Akihito Nagata ◽  
Yusuke Kanemasa ◽  
Miyu Kikuchi ◽  
Ryohei Otani ◽  
Ryoji Yamada ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Glioblastoma Multiforme ◽  
Myeloid Leukemia ◽  
Morphological Characteristics ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Metastasis ◽  
Severe Pancytopenia ◽  
Cluster Of Differentiation ◽  
Acute Myeloid

Abstract A 46-year-old female patient with glioblastoma multiforme (GBM), IDH wild type developed severe pancytopenia 5 months after postoperative chemoradiotherapy. Bone marrow aspirate showed normocellular marrow with 70.0% abnormal cells, which suggested the possibility of acute myeloid leukemia. Immunophenotypic analysis did not show any hematological lineage markers, except for cluster of differentiation 56. The results of immunohistochemical staining of glial fibrillary acidic protein and oligodendrocyte transcription Factor 2 were positive. Based on these findings, the patient was diagnosed with bone marrow metastasis from GBM. Bone marrow metastasis from GBM is rare and little is known about the morphological characteristics of bone marrow aspiration smear findings. We experienced a rare case with marrow metastasis from GBM mimicking acute myeloid leukemia.

Vitamin B12 Deficiency an Unusual Cause of Fever: A Case Report

2019 ◽  
Vol 4 (02) ◽  
Author(s):  
Shyama . ◽  
P. Kumar ◽  
Surabhi .
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Unusual Case ◽  
Vitamin B12 Deficiency ◽  
Bone Marrow Aspiration ◽  
Microcytic Anemia ◽  
Peripheral Smear ◽  
Erythroid Hyperplasia ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Introduction: An unusual case of a 19 year old female, presenting with fever, pallor and hepatosplenomegaly for one month. She had microcytic anemia on peripheral smear examination but her bone marrow aspiration & biopsy revealed a hypercelluar marrow with megaloblastic erythroid hyperplasia. Resolution of fever within 48 hours of Vitamin B12 supplementation, initiated in view of the megaloblastic bone marrow picture & low serumVitamin B12 level, suggests a causal association. Conclusion: Vitamin B12 deficiency seems to be an unusual cause of PUO (Pyrexia of unkown origin) which should be ruled out in every case of PUO.

Understanding bone safety zones during bone marrow aspiration from the iliac crest: the sector rule

2014 ◽  
Vol 38 (11) ◽  
pp. 2377-2384 ◽  
Author(s):  
Jacques Hernigou ◽  
Laure Picard ◽  
Alexandra Alves ◽  
Jonathan Silvera ◽  
Yasuhiro Homma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Iliac Crest ◽  
Bone Marrow Aspiration

scholarly journals Evaluation of qPCR on blood and skin microbiopsies, peripheral blood buffy coat smear, and urine antigen ELISA for diagnosis and test of cure for visceral leishmaniasis in HIV-coinfected patients in India: a prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042519
Author(s):  
Sophie I Owen ◽  
Sakib Burza ◽  
Shiril Kumar ◽  
Neena Verma ◽  
Raman Mahajan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Peripheral Blood ◽  
Medical Science ◽  
Bone Marrow Aspiration ◽  
Buffy Coat ◽  
Tropical Medicine ◽  
Urine Antigen ◽  
Antigen Elisa

IntroductionHIV coinfection presents a challenge for diagnosis of visceral leishmaniasis (VL). Invasive splenic or bone marrow aspiration with microscopic visualisation of Leishmania parasites remains the gold standard for diagnosis of VL in HIV-coinfected patients. Furthermore, a test of cure by splenic or bone marrow aspiration is required as patients with VL-HIV infection are at a high risk of treatment failure. However, there remain financial, implementation and safety costs to these invasive techniques which severely limit their use under field conditions.Methods and analysisWe aim to evaluate blood and skin qPCR, peripheral blood buffy coat smear microscopy and urine antigen ELISA as non-invasive or minimally invasive alternatives for diagnosis and post-treatment test of cure for VL in HIV-coinfected patients in India, using a sample of 91 patients with parasitologically confirmed symptomatic VL-HIV infection.Ethics and disseminationEthical approval for this study has been granted by The Liverpool School of Tropical Medicine, The Institute of Tropical Medicine in Antwerp, the University of Antwerp and the Rajendra Memorial Research Institute of Medical Science in Patna. Any future publications will be published in open access journals.Trial registration numberCTRI/2019/03/017908.

scholarly journals A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

2016 ◽  
Vol 6 ◽  
pp. 45-46
Author(s):  
Jeffrey J. Tosoian ◽  
Diane K. Reyes ◽  
Michael A. Gorin ◽  
Steven Hortopan ◽  
Alan W. Partin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Radical Prostatectomy ◽  
Bone Marrow Aspiration ◽  
Novel Approach
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