scholarly journals Bone marrow involvement as a rare manifestation of relapsed choroidal melanoma

2020 ◽  
Vol 8 (8) ◽  
pp. 3110
Author(s):  
Nusrat Bashir ◽  
Farzana Manzoor ◽  
Bilal Musharaf ◽  
Ruby Reshi
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Choroidal Melanoma ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Metastasis ◽  
Common Site ◽  
Immune Histochemistry ◽  
Rare Manifestation ◽  
Disseminated Disease

Choroidal Melanoma is the most common primary intra-ocular malignancy. Incidence of primary choroidal melanoma is about 6 cases per 1 million population. It disseminates hematogenously. The most common site of metastasis is liver. Metastatic melanoma involving the bone marrow is rare, occurring in 5% of patients with disseminated disease. However, Choroid melanoma with bone marrow involvement is very rare. Only a few case reports are published in literature.  Authors present a case of bone marrow metastasis from choroid melanoma in 55 years old female who has been treated for primary choroidal melanoma by enucleation of left eye three years back. In the evaluation of symptomatic anemia, features suggestive of bone marrow infiltration by choroidal melanoma were observed on bone marrow aspiration and biopsy. The diagnosis was confirmed by positivity of immune-histochemistry markers HMB-45 and Melana.

Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis

2019 ◽  
Vol 105 (5) ◽  
pp. 388-393
Author(s):  
Di Wang ◽  
Yang Luo ◽  
Di Shen ◽  
Lin Yang ◽  
Hui-Ying Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lung Adenocarcinoma ◽  
Survival Time ◽  
Kinase Inhibitor ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Best Supportive Care ◽  
Bone Marrow Metastasis ◽  
Platinum Based Chemotherapy ◽  
Targeted Drug

Background: Bone marrow metastasis occurs in lung adenocarcinoma patients with a poor prognosis due to the late course and lack of definitive treatments, although reports on this are limited. This study analyzed the clinical manifestation, laboratory examination, treatment, and prognosis of patients with lung adenocarcinoma with bone marrow metastasis. Methods: All patients were confirmed to have bone marrow infiltration by bone marrow aspiration. The clinical data of 12 patients with lung adenocarcinoma with bone marrow metastasis were analyzed retrospectively. The prognostic factors were analyzed by Kaplan-Meier statistics. Results: The common biomarker abnormalities in 12 patients were elevated carcinoembryonic antigen in 12 cases (100%), elevated lactate dehydrogenase in 9 cases (75%), increased alkaline phosphatase and anemia in 8 cases each (66.7%), and thrombocytopenia in 4 cases (33.3%). After diagnosis of bone marrow metastasis, 5 patients were treated with platinum-based chemotherapy, 3 patients received chemotherapy and targeted drug tyrosine kinase inhibitor (TKI) therapy, 2 patients received simple TKI therapy, and 2 patients received only best supportive care (BSC) therapy. The median duration of survival after the diagnosis of bone marrow involvement was 422 days. The survival time of patients receiving TKI therapy after bone marrow metastasis was significantly better than that of patients receiving only BSC and chemotherapy (χ2=4.636, P=0.031). Conclusions: The survival period of patients with lung adenocarcinoma with bone marrow metastasis is short, and targeted drug TKI treatment can prolong the survival time for patients with EGFR mutation–carrying lung adenocarcinoma with bone marrow metastasis.

scholarly journals Simultaneous Occurrence of Ocular, Disseminated Mucocutaneous, and Multivisceral Involvement of Leishmaniasis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Cyriac Abby Philips ◽  
Chetan Ramesh Kalal ◽  
K. N. Chandan Kumar ◽  
Chhagan Bihari ◽  
Shiv Kumar Sarin
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
New World ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Immunocompetent Patient ◽  
Simultaneous Occurrence ◽  
Ocular Involvement ◽  
Disseminated Disease ◽  
Visceral Disease

Leishmaniasis is a tropical infection caused by the protozoan, belonging to the group ofLeishmaniawhich causes Old World and New World disease. These are typically divided into cutaneous, mucocutaneous, visceral, viscerotropic, and disseminated disease. Cutaneous leishmaniasis in the presence of visceral disease is a rarity. Isolated case reports have documented this occurrence, in the immunocompromised setting, and few otherwise. The concurrent presence of visceral leishmaniasis (bone marrow involvement) with solitary cutaneous and ocular disease and also solitary cutaneous and visceral disease (bone marrow involvement) has been reported before. Here, we present an immunocompetent patient who was diagnosed to have visceral leishmaniasis (liver and bone marrow involvement) along with simultaneous disseminated mucocutaneous and ocular involvement, a combination that has never been reported before.

scholarly journals Bone marrow trephine biopsy in Haematological diseases: a study of 53 cases

2015 ◽  
Vol 22 (2) ◽  
pp. 207-210
Author(s):  
Hazera Khatun ◽  
Salma Afrose ◽  
Mohiuddin Ahmed Khan ◽  
Tasneem Ara ◽  
Mohammad Sirajul Islam ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Polycythaemia Vera ◽  
Safe Procedure ◽  
Trephine Biopsy ◽  
Lymphoid Aggregate ◽  
Medical College ◽  
Bone Marrow Trephine Biopsy ◽  
Adults And Children

Bone marrow aspiration (BMA) and biopsy (BMTB) are important investigations for diagnosis of haematolgical malignancies and non-malignant diseases both in adults and children. BMA and BMTB are complementary and if both are done a comprehensive analysis of bone marrow involvement is possible. 53 cases of BMTB were studied in order to underscore the indications and importance of BMTB. BMTB was done to determine cellularity in aplastic anaemia (AA) (33.96%, n=18) and in cases of failure of aspiration (32.08%, n=17). Failure of aspiration was attributable to bone marrow (BM) fibrosis (76%, n=13) due to acute leukaemia (35.30%, n=6) and myelofibrosis (43.17%, n=7). BMTB upstaged non Hodgkin’s lymphoma (NHL) from IIIB to IVB in 22.22% cases. 1 case of AA showed focal lymphoid aggregate which later evolved into acute lymphoblastic leukaemia (ALL). BMTB is a safe procedure and increased bleeding was noted only in a case of polycythaemia vera. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21544 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 207-210

Multiple Myeloma Associated GI Polyposis

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5009-5009
Author(s):  
Nassim Nabbout ◽  
Mohamad El Hawari ◽  
Thomas K. Schulz
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cells ◽  
Conflicts Of Interest ◽  
Case Reports ◽  
Bone Marrow Failure ◽  
Bone Lesions ◽  
Rare Manifestation ◽  
History Of ◽  
Central Ulceration

Abstract Abstract 5009 Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells that can result in osteolytic bone lesions, hypercalcemia, renal impairment, bone marrow failure, and the production of monoclonal gammopathy. The gastrointestinal tract is rarely involved in myeloma. GI polyposis is a rare manifestation of extra-medullary disease in multiple myeloma. Such cases usually present as gastrointestinal hemorrhage or intestinal obstruction. A 53-year-old African American male recently diagnosed with multiple myeloma presented with three-day history of rectal bleed and fatigue. EGD showed multiple raised, polypoid, rounded lesions with a superficial central ulceration in the stomach. Colonoscopy showed similar lesions in the ascending and transverse areas of the colon that ranged in size from 5 to 16 mm in diameter. Biopsies showed that these polyps were made of plasma cells. A bone marrow biopsy showed diffuse involvement (greater than 90%) of bone marrow with multiple myeloma with anaplastic features. The patient was started on bortezomib at diagnosis, however, he passed away a few weeks later. This type of metastatic disease has been described in isolated case reports in the literature, while solitary GI plasmacytoma has been reported more frequently. In rare cases, multiple myeloma can involve the GI tract which may lead to bleed or obstruction. This involvement is likely a marker of aggressivity. This example of extra-medullary disease in myeloma is an uncommon variant with features of poor prognosis and dedifferentiation. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities

2020 ◽  
Vol 222 (11) ◽  
pp. 1807-1815 ◽  
Author(s):  
Laura Falasca ◽  
Roberta Nardacci ◽  
Daniele Colombo ◽  
Eleonora Lalle ◽  
Antonino Di Caro ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Whole Body ◽  
Pathological Features ◽  
Autopsy Study ◽  
Multisystem Disease ◽  
Transmission Electron ◽  
Significant Pathology ◽  
Postmortem Studies

Abstract Background Descriptions of the pathological features of coronavirus disease-2019 (COVID-19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients have been sparse. Methods To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients with COVID-19 (18 with comorbidities and 4 without comorbidities) who died at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. Tissues from the lung, heart, liver, kidney, spleen, and bone marrow (but not the brain) were examined. Only lung tissues were subject to transmission electron microscopy. Results COVID-19 caused multisystem pathology. Pulmonary and cardiovascular involvement were dominant pathological features. Extrapulmonary manifestations included hepatic, kidney, splenic, and bone marrow involvement, and microvascular injury and thrombosis were also detected. These findings were similar in patients with or without preexisting medical comorbidities. Conclusions SARS-CoV-2 infection causes multisystem disease and significant pathology in most organs in patients with and without comorbidities.

scholarly journals Bone Marrow Burkitt Lymphoma in a Child

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Matija Knežić ◽  
Irena Seili Bekafigo ◽  
Jelena Roganović ◽  
Ita Hadžisejdić ◽  
Nives Jonjić
Keyword(s):  
Bone Marrow ◽  
Flow Cytometry ◽  
Burkitt Lymphoma ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Diagnostic Process ◽  
Extranodal Disease

Burkitt lymphoma (BL) is a highly aggressive but potentially curable disease as long as adequately treated within due time. BL may occur primarily and exclusively in the bone marrow as a form of peripheral and extranodal disease. BL cases with isolated bone marrow involvement are challenging in regard to a prompt diagnostic process. We report a case of a sporadic extranodal subtype of isolated bone marrow BL in an 11-year-old boy. Bone marrow aspiration and biopsy, flow cytometry, and immunohistochemistry along with cytogenetics are compulsory in order to achieve the adequate diagnosis.

Unusual primary presentations of mantle cell lymphoma in the urinary tract and testes.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e18503-e18503
Author(s):  
Deniz Peker ◽  
Timothy Edward Kubal ◽  
Eduardo M. Sotomayor ◽  
Lubomir Sokol ◽  
Jennifer L. Cultrera ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Urinary Tract ◽  
Complete Remission ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Bone Marrow Involvement ◽  
Genitourinary Tract ◽  
Cancer Center ◽  
Mantle Cell ◽  
Disseminated Disease

e18503 Background: The initial clinical presentation of Mantle Cell Lymphoma is protean, ranging from single sites of indolent disease followed for years without therapy to aggressive disseminated disease that requires treatment within weeks of diagnosis. While many cases of Mantle Cell Lymphoma present with disseminated disease, other patients may present with symptoms related to a primary extranodal site of disease. The majority of these primary extranodal cases are diagnosed in the gastrointestinal tract, other cases have been noted in the skin, conjunctiva, testes and male genitourinary tract. Methods: Database review of 204 patients diagnosed with Mantle Cell Lymphoma at Moffitt Cancer Center between May 1992 and December 2010. Results: Three cases of Mantle Cell Lymphoma presented with symptoms related to primary extranodal sites in the urinary tract and male genital organs. Two cases of testicular involvement presented with gradual enlargement of the testes. In patient 1, the orchiectomy specimen harbored both seminoma and mantle cell lymphoma. Low level bone marrow involvement by mantle cell lymphoma was present and in the presence of indolent features he was treated for his primary seminoma and followed expectantly for mantle cell lymphoma. In patient 2, orchiectomy revealed a pleomorphic variant of mantle cell lymphoma with no other sites of disease on staging workup. He was treated with 6 cycles of R-CHOP and prophylactic IT methotrexate with a complete remission. A third patient presented with obstructive urinary symptoms and was found to have mantle cell lymphoma of the prostate. Additional staging revealed diffuse lymphadenopathy, colon and bone marrow involvement. A complete remission was obtained with 6 cycles of R-CHOP. None of these three patients was found to have evidence of CNS involvement at diagnosis or in followup with only the second patient receiving intrathecal prophylaxis. Conclusions: Mantle Cell Lymphoma may present with unusual extranodal involvement at diagnosis including sites and symptoms related to the genitourinary tract and testes. Diagnostic lumbar puncture and intrathecal prophylaxis should be considered in these patients.

scholarly journals LINC-34. OPTIC NERVE INFILTRATION: RARE MANIFESTATION OF CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN REMISSION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii385-iii385
Author(s):  
Ludi Dhyani Rahmartani
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Optic Nerve ◽  
B Cell ◽  
Large Scale ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Aspiration ◽  
Clinical Findings ◽  
Diagnostic Certainty ◽  
Rare Manifestation

Abstract BACKGROUND Optic nerve infiltration in acute lymphoblastic leukemia is a rare manifestation. This infiltration may appear months in advance as an isolated sign of extramedullary relapse and considered as one of the significant clinical findings of central nervous system leukemia. AIM: To describe a case of rapidly progressive optic nerve infiltration in a girl with ALL in remission. CASE: A 13-year-old girl in full remission following treatment for B-cell acute lymphoblastic leukemia presented with decreased vision and proptosis on the left eye. She completed the chemotherapy course two years before. On physical examination, we found the optic disc swelling in her left eyes. There were no signs of relapse from the hematological, cerebrospinal fluid analysis, and bone marrow aspiration. The orbital CT found a mass on the left retrobulbar (size 29x48x32 mm), suspected of optic nerve glioma. The mass has grown rapidly in a month, and she lost her left sight. The involved eye was exenterated (60x55x40 mm). The histopathology and immunohistochemistry showed the B-cell acute lymphoblastic lymphoma. Unfortunately, the patient could not come for further follow up due to the COVID-19 large-scale social distancing. Two months later, she came with pallor and pain in all of her body. The bone marrow aspiration showed leukemic relapse and she is undergoing chemotherapy. CONCLUSION Optic nerve infiltration by leukemia requires both diagnostic certainty and urgent management. A routine ophthalmic assessment is recommended in patients with a history of acute lymphoblastic leukemia to diagnose optic nerve involvement due to leukemic infiltration.

Sign in / Sign up

Export Citation Format

Share Document