scholarly journals 18F-FES and 18F-FDG PET for Differential Diagnosis and Quantitative Evaluation of Mesenchymal Uterine Tumors: Correlation with Immunohistochemical Analysis

2013 ◽  
Vol 54 (4) ◽  
pp. 499-506 ◽  
Author(s):  
Z. Zhao ◽  
Y. Yoshida ◽  
T. Kurokawa ◽  
Y. Kiyono ◽  
T. Mori ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Quantitative Evaluation ◽  
Fdg Pet ◽  
Immunohistochemical Analysis ◽  
Uterine Tumors ◽  
18F Fdg

scholarly journals Neoadjuvant Pazopanib Treatment in High-Risk Soft Tissue Sarcoma: A Quantitative Dynamic 18F-FDG PET/CT Study of the German Interdisciplinary Sarcoma Group

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 790 ◽  
Author(s):  
Christos Sachpekidis ◽  
Ioannis Karampinis ◽  
Jens Jakob ◽  
Bernd Kasper ◽  
Kai Nowak ◽  
...  
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Kinetic Analysis ◽  
Quantitative Evaluation ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Pet Ct ◽  
18F Fdg ◽  
Regression Grade

The outcome of high-risk soft tissue sarcoma (STS) is poor with radical surgery being the only potentially curative modality. Pazopanib is a multikinase inhibitor approved for the treatment of metastatic STS. Herein, in terms of the German Interdisciplinary Sarcoma Group (GISG-04/NOPASS) trial, we evaluate the potential role of kinetic analysis of fludeoxyglucose F-18 (18F-FDG) data derived from the application of dynamic positron emission tomography/computed tomography (PET/CT) in response assessment to pazopanib of STS patients scheduled for surgical resection. Sixteen STS patients treated with pazopanib as neoadjuvant therapy before surgery were enrolled in the analysis. All patients underwent dynamic PET/CT prior to and after pazopanib treatment. Data analysis consisted of visual (qualitative) analysis of the PET/CT scans, semi-quantitative evaluation based on standardized uptake value (SUV) calculations, and quantitative analysis of the dynamic 18F-FDG PET data, based on two-tissue compartment modeling. Resection specimens were histopathologically assessed and the percentage of regression grade was recorded in 14/16 patients. Time to tumor relapse/progression was also calculated. In the follow-up, 12/16 patients (75%) were alive without relapse, while four patients (25%) relapsed, among them one patient died. Median histopathological regression was 20% (mean 26%, range 5–70%). The studied population was dichotomized using a histopathological regression grade of 20% as cut-off. Based on this threshold, 10/14 patients (71%) showed partial remission (PR), while stable disease (SD) was seen in the rest 4 evaluable patients (29%). Semi-quantitative evaluation showed no statistically significant change in the widely used PET parameters, SUVaverage and SUVmax. On the other hand, 18F-FDG kinetic analysis revealed a significant decrease in the perfusion-related parameter K1, which reflects the carrier-mediated transport of 18F-FDG from plasma to tumor. This decrease can be considered as a marker in response to pazopanib in STS and could be due to the anti-angiogenic effect of the therapeutic agent.

Is 18F-FDG PET/CT capable of differential diagnosis from tuberculous pleurisy from malignant mesothelioma?

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Özlem Özmen ◽  
Ebru Tatci ◽  
Ş. Mustafa Demiröz ◽  
Zuhal Tazeler ◽  
Funda Demirağ
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Fdg Pet ◽  
Pet Ct ◽  
Tuberculous Pleurisy ◽  
18F Fdg ◽  
Fdg Pet Ct

The use of 18F-FDG PET ratios in the differential diagnosis of common malignant brain tumors

2015 ◽  
Vol 39 (6) ◽  
pp. 970-974 ◽  
Author(s):  
Kaan Meric ◽  
Ronan P. Killeen ◽  
Alain S. Abi-Ghanem ◽  
Fatima Soliman ◽  
Fuad Novruzov ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Brain Tumors ◽  
Fdg Pet ◽  
Malignant Brain Tumors ◽  
18F Fdg

scholarly journals Multiparameter Analysis Using 18F-FDG PET/CT in the Differential Diagnosis of Pancreatic Cystic Neoplasms

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Guanyun Wang ◽  
Haodan Dang ◽  
Peng Yu ◽  
Honghong Liu ◽  
Yue Wu ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fdg Pet ◽  
Diagnostic Value ◽  
Combined Model ◽  
Cystic Neoplasms ◽  
Diagnostic Efficacy ◽  
Multiple Parameters ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Purpose. To evaluate multiparametric analysis in differential diagnosis between pancreatic serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) as well as the differentiation of the benign and malignant MCNs with 18F-FDG (18-fluorodeoxyglucose) PET/CT (positron emission tomography). Methods. Forty patients with total of 41 lesions (SCNs: 27/41; MCNs: 14/41), who were preoperatively examined with 18F-FDG PET/CT, were retrospectively analyzed. Multiple quantitative parameters using conventional and texture features were included. The combined model was established with complementary PET/MR parameters. The differential diagnostic efficacy of each independent parameter and the combined model were evaluated with receiver operating characteristic (ROC) analysis. Integrated discriminatory improvement (IDI) and net reclassification improvement (NRI) were used to evaluate improvement of diagnostic efficacy by using combination of multiple parameters. Results. Among all independent parameters, the percentile 5th (0.88 ± 0.38 vs 0.47 ± 0.23, P < 0.001 ) showed the highest discriminative diagnostic value. The combination of multiple parameters can improve the differential diagnostic efficacy of SCNs and MCNs (sensitivity = 71.4%, specificity = 77.8%, and AUC = 0.788), and the addition of texture parameters to the conventional parameters allowed a significant reclassification with IDI = 0.236 (95% CI: 0.095–0.377) and categorical NRI = 0.434 (95% CI: 0.030–0.838). SURmax (tumor to normal pancreas ratio, T/P) and SURmax (tumor to aorta ratio, T/A) both showed the highest discriminative diagnostic value (sensitivity = 100.0%, specificity = 70.0%, AUC = 0.900, and Youden index = 0.700) in the differential diagnosis of benign and malignant MCNs, with the cutoff values of 0.84 and 0.90, respectively. Conclusion.Combination of multiple parameters using 18F-FDG PET/CT could further improve differentiation between pancreatic SCNs and MCNs. SURmax (T/P) and SURmax (T/A) could improve differential diagnosis of benign and malignant MCNs.

Brain 18F-FDG PET Imaging in the Differential Diagnosis of Parkinsonism

2014 ◽  
Vol 39 (3) ◽  
pp. e220-e226 ◽  
Author(s):  
Ümit Özgür Akdemir ◽  
Ayşe Bora Tokçaer ◽  
Asl Karakuş ◽  
Lütfiye Özlem Kapucu
Keyword(s):  
Differential Diagnosis ◽  
Pet Imaging ◽  
Fdg Pet ◽  
18F Fdg

Comparison of brain MRI and 18F-FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease

2007 ◽  
Vol 22 (16) ◽  
pp. 2352-2358 ◽  
Author(s):  
Kyum-Yil Kwon ◽  
Choong G. Choi ◽  
Jae S. Kim ◽  
Myoung C. Lee ◽  
Sun J. Chung
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Differential Diagnosis ◽  
Multiple System Atrophy ◽  
Fdg Pet ◽  
Brain Mri ◽  
18F Fdg
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