scholarly journals Socio-group Agents Promoting Vaccination against Covid-19: A Comparative Analysis of the Positions of Medical Workers and Blood Plasma Donors

Author(s):  
Oksana Nekhaienko ◽  
Dmytro Boyko ◽  
Tatyana Chumachenko
2019 ◽  
Vol 7 (4) ◽  
pp. 288-293
Author(s):  
Miroslav Vasilev ◽  
Galya Shivacheva

Phase space is an approach for analysis of nonlinear differential equations. The graphical solutions that are obtained are convenient for qualitative assessment of the behavior of systems and processes. A comparative analysis of the pharmacokinetics of the antibiotic enrofloxacin administered intravenously in dogs and cats has been performed in the present study. The mathematical models that represent the change in blood plasma concentration of the two groups of animals are described by second-order differential equations. For the graphical representation of phase trajectories using the fluoroquinolone, the Mathcad program tools are used. The properties of the peculiar points are determined based on the received images.


2017 ◽  
Vol 6_2017 ◽  
pp. 74-82
Author(s):  
Borisova A.V. Borisova ◽  
Chagovets V.V. Chagovets ◽  
Kozachenko A.V. Kozachenko ◽  
Starodubtseva N.L. Starodubtseva N ◽  
Kononikhin A.S. Kononikhin ◽  
...  

Author(s):  
Miroslav Vasilev ◽  
Galya Shivacheva

Phase space is an approach for analysis of nonlinear differential equations. The graphical solutions that are obtained are convenient for qualitative assessment of the behavior of systems and processes. A comparative analysis of the pharmacokinetics of the antibiotic enrofloxacin administered intravenously in dogs and cats has been performed in the present study. The mathematical models that represent the change in blood plasma concentration of the two groups of animals are described by second-order differential equations. For the graphical representation of phase trajectories using the fluoroquinolone, the Mathcad program tools are used. The properties of the peculiar points are determined based on the received images.


2019 ◽  
Vol 167 (1) ◽  
pp. 91-96 ◽  
Author(s):  
A. L. Kaysheva ◽  
A. T. Kopylov ◽  
N. E. Kushlinskii ◽  
E. S. Gershtein ◽  
A. A. Alferov ◽  
...  

1991 ◽  
Vol 65 (3) ◽  
pp. 445-455 ◽  
Author(s):  
N. M. Lowe ◽  
I. Bremner ◽  
M. J. Jackson

The amount of 65Zn in the plasma of rats after intravenous injection was found to decline following closely two-compartment kinetics over a period of 90 min. Comparative analysis of the amount of 65Zn present in the two kinetic pools at various time-intervals post-injection with the actual physiological location of the 65Zn, revealed that the initial pool (Qa) is primarily the blood plasma, while the second pool (Qb) is primarily within the liver. The plasma Zn concentration and Qa were both found to fall reproducibly during Zn depletion, whereas Qa and Qb increased following injection of Escherichia coli endotoxin in contrast to the decline in plasma Zn concentration. Further investigation of the nature of Qb indicates that it represents in part a metabolic pool within the liver which varies substantially in response to Zn status in a manner similar to metallothionein.


2017 ◽  
Vol 24 (7) ◽  
pp. S54-S55
Author(s):  
A. Borisova ◽  
L.V. Adamyan ◽  
A. Kozachenko ◽  
A. Stepanian ◽  
V. Chagovets ◽  
...  

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Svetlana N. Kondratenko ◽  
Irina V. Zolkina ◽  
Eugenia V. Shikh

AbstractObjectivesThe pharmacokinetics of moxifloxacin in plasma and saliva was investigated in this study.MethodsThe pharmacokinetics of two specialty drugs of moxifloxacin – reference (Ref) and test (Test) preparation – was studied in 18 healthy volunteers after a single oral dose of 400 mg.ResultsIt was found that the concentration of moxifloxacin in saliva 3–24 h after taking the drugs was statistically significantly higher than that in plasma. A high correlation was observed between the concentration of moxifloxacin in plasma and saliva of volunteers after taking of Ref and Test. Some pharmacokinetic parameters, calculated by the concentration of moxifloxacin in saliva and plasma, are statistically different. A technique is proposed for extrapolating the concentration of moxifloxacin in plasma according to its concentration in saliva using the established linear relationship between the moxifloxacin in plasma and saliva of volunteers in time interval of 3–24 h after taking Ref. Based on the obtained extrapolated concentration of moxifloxacin, the pharmacokinetic parameters were calculated for two studied drugs and did not statistically differ from the parameters calculated according to the data in plasma.ConclusionsThe developed method of concentration extrapolation allows the use of saliva for pharmacokinetic studies of the tablet preparations of moxifloxacin.


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