2020 ◽  
Author(s):  
Sofia Alexandra Milheiro ◽  
Joana Gonçalves ◽  
Ricardo Lopes ◽  
Margarida Madureira ◽  
Lis Lobo ◽  
...  

<p><a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds of general formula [(</a>η<sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Ru(PPh<sub>3</sub>)(N-N)][PF<sub>6</sub>], a scaffold hitherto unfeatured in the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 <i>Plasmodium falciparum</i> strains, and the liver stage of <i>P. berghei</i>. The best performing compounds displayed dual-stage activity, with single-digit nM IC<sub>50</sub> values against blood stage malaria parasites, nM activity against liver stage parasites, and residual cytotoxicity against mammalian cells (HepG2, Huh7). Parasitic absorption/distribution of 7-nitrobenzoxadiazole-appended fluorescent compounds <b>Ru4</b> and <b>Ru5</b> was investigated by confocal fluorescence microscopy, revealing parasite-selective absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound <b>Ru2</b> impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized <i>P. falciparum</i> 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage antiplasmodials.</p>


Author(s):  
Ning-Ning Cheng ◽  
Zi-Liang Li ◽  
Hong-Chao Lan ◽  
Wen-Long Xu ◽  
Wen-Jing Jiang ◽  
...  

Author(s):  
Patricia Luis ◽  
Inmaculada Ortiz ◽  
Rubén Aldaco ◽  
Aurora Garea ◽  
Ángel Irabien

Removal of SO2 from gas emissions by selective absorption into a liquid is a common method to reduce air pollution and environmental risks. The absorption efficiency is determined by the interaction between the gases and the liquid. A great number of gas desulphurization methods have been developed where aqueous or organic solvents are used as sorbents.N,N-dimethylaniline (DMA) is an organic solvent used in the industry because its affinity with SO2. This absorption is neither too strong nor too weak, thus absorption and desorption can occur leading to a regenerative process where SO2 can be recovered. However, a direct contact between SO2 and DMA leads to several environmental problems caused by solvent evaporation and drops dragging into the gas stream.In order to increase the process efficiency and reduce environmental risks, a non-dispersive absorption process using hollow fibre membrane modules is developed in this work for a solvent zero emission process. The mass transfer into a fibre may be described by three main assumptions: gas-phase laminar flow, gas-phase plug-flow and gas-phase mixing. A numerical calculation was carried out to establish the performance of a hollow fibre membrane contactor for the removal of SO2 when water and N,N-dimethylaniline are used as sorbents in order to compare both, wetted and non-wetted operating modes.


2006 ◽  
Vol 3 (4) ◽  
pp. 1201-1204
Author(s):  
M. Szot ◽  
K. Karpierz ◽  
D. K. Maude ◽  
M. L. Sadowski ◽  
J. Kossut ◽  
...  

2013 ◽  
Vol 70 (3) ◽  
pp. 743-766 ◽  
Author(s):  
Akira Yamazaki ◽  
Hisanori Itoh

Abstract The selective absorption mechanism (SAM), newly proposed in Part I of this study on the maintenance mechanism of blocking, is verified through numerical experiments. The experiments were based on the nonlinear equivalent-barotropic potential vorticity equation, with varying conditions with respect to the shape and amplitude of blocking, and characteristics of storm tracks (displacement and strength) and background zonal flow. The experiments indicate that the SAM effectively maintains blocking, irrespective of the above conditions. At first, by applying a channel model on a β plane, numerical experiments were conducted using a uniform background westerly with and without a jet. The results show that the presence of a jet promotes the effectiveness of the SAM. Then, two types of spherical model experiments were also performed. In idealized experiments, the SAM was as effective as the β-plane model in explaining the maintenance of blocking. Moreover, experiments performed under realistic meteorological conditions showed that the SAM maintained a real block, demonstrating that the SAM is effective. These results, and the case study in Part I, verify that the SAM is the effective general maintenance mechanism for blocking.


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