scholarly journals Evaluating the Effect of Supernatant Collected from the Culture of Bifidobacterium bifidum on the Increase of Angiogenesis in Acute Wound Healing

2021 ◽  
Vol 15 (5) ◽  
pp. 552-570
Author(s):  
Pegah Moussavi amin ◽  
Akram Sadat Tabatabaee Bafroee ◽  
Babak Khalili Hadad ◽  
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...  
2008 ◽  
Author(s):  
Elisabeth S. Papazoglou ◽  
Michael S. Weingarten ◽  
Leonid Zubkov ◽  
Michael Neidrauer ◽  
Linda Zhu ◽  
...  
Keyword(s):  

Author(s):  
Nazira Fatima ◽  
Muhammad Saleem

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.


2019 ◽  
Author(s):  
Lee D. Faucher ◽  
Angela L. Gibson

Acute wounds are the result of local trauma and may be associated with severe life-threatening injuries. All patients with acute wounds should be assessed for comorbidities such as malnutrition, diabetes, peripheral vascular disease, neuropathy, obesity, immune deficiency, autoimmune disorders, connective tissue diseases, coagulopathy, hepatic dysfunction, malignancy, smoking practices, medication use that could interfere with healing, and allergies. The authors address the key considerations in management of the acute wound, including anesthesia, location of wound repair (e.g. operating room or emergency department), hemostasis, irrigation, débridement, closure materials, timing and methods of closure, adjunctive treatment (e.g. tetanus and rabies prophylaxis, antibiotics, and nutritional supplementation), appropriate closure methods for specific wound types, dressings, postoperative wound care, and potential disturbances of wound healing.  This review contains 11 figures, 31 tables, and 92 references. Keywords: wound, wound infection, burns, suture, staple, wound closure, wound healing, dehiscence, skin grafting


2019 ◽  
Vol 571 ◽  
pp. 118707 ◽  
Author(s):  
Zhejie Chen ◽  
Yichen Hu ◽  
Jie Li ◽  
Chen Zhang ◽  
Fei Gao ◽  
...  

Author(s):  
Hilda Brigitta Sombolayuk ◽  
Khairuddin Djawad ◽  
Siswanto Wahab ◽  
Upik A. Miskad ◽  
Gemini Alam ◽  
...  

Wound healing is a complex physiological process consisting of four phases: coagulation, inflammation, proliferation and migration, and remodeling, each with distinct characteristics. Studies have suggested that mangosteen pericarp extract (MPE) may accelerate wound healing. However, the mechanism has not been fully understood. This study aims to evaluate the effect of MPE cream in various concentrations in acute wound healing of albino mice, both histologically and macroscopically. Thirty-two healthy female Swiss albino mice, aged 6-9 weeks, weight 20-30 g, were included in this study. The samples were randomly divided into eight groups each consisting of 4 mice. The first four groups were treated with MPE cream 5%, 10%, and 20%, and no medication (control group), respectively, and were sacrificed after three days. The other four groups received the same application and were sacrificed after 8 days. Wound bed diameter was measured and biopsy from the skin lesion was performed for histopathologic examination. Mann-Whitney test was used to analyze the diameter of the wound bed and histopathological findings of granulation tissue formation, reepithelialization, and inflammation, with P<0.05 considered as significant. MPE cream significantly improved wound healing by increasing granulation tissue formation, and reepithelialization. In addition, MPE cream application was also shown to decrease the number of inflammatory cells, particularly in 5% and 10% concentrations, both in the 3-day and 8-day groups. MPE cream application can accelerate wound healing and thus can be used in acute wound treatment.


2007 ◽  
Vol 25 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Jie Li ◽  
Juan Chen ◽  
Robert Kirsner
Keyword(s):  

2014 ◽  
Vol 133 (2) ◽  
pp. 208e-215e ◽  
Author(s):  
Phillip B. Dauwe ◽  
Benson J. Pulikkottil ◽  
Lawrence Lavery ◽  
James M. Stuzin ◽  
Rod J. Rohrich

2010 ◽  
Vol 18 (1) ◽  
pp. 105-113 ◽  
Author(s):  
Nathan B. Menke ◽  
John W. Cain ◽  
Angela Reynolds ◽  
David M. Chan ◽  
Rebecca A. Segal ◽  
...  
Keyword(s):  

2005 ◽  
Vol 114 (4) ◽  
pp. 296-303 ◽  
Author(s):  
Seth M. Cohen ◽  
C. Gaelyn Garrett ◽  
Shan Huang ◽  
Mark S. Courey

This study evaluates how extraesophageal reflux affects membranous vocal fold healing in a canine model. We created membranous vocal fold injuries in the animals and randomly assigned them to topical application of acid and pepsin at pH 2 or pH 6 or of normal saline solution every other day for 12 days. The experimental vocal folds were compared to uninjured, control vocal folds from animals painlessly sacrificed for other reasons. Hematoxylin and eosin, fibronectin, and procollagen I staining were performed for histologic analysis. The injured specimens had three times greater cellular infiltrate (p ≤ .001, analysis of variance) and twice as much fibronectin and procollagen I (p ≤ .001, analysis of variance) as did the specimens from the control animals. No significant differences or trends were identified for cellular infiltrate, fibronectin, or procollagen I within the injured groups (p > .05, Bonferroni t-test). Acute wound healing did not appear to be influenced by the presence of acid and pepsin at pH 2 or 6 as compared to saline solution.


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