The authors studied the efficiency of the Neuromidin in complex treatment of the patients with primary open-angle glaucoma. 65 patients (130 eyes), of which 44 advanced stage, 76 - with severe and 10 eyes with a terminal stage of primary open-angle glaucoma (POAG) were examined. These patients received the Neuromidin in the dose of 1 ml (15 mg) intramuscularly, №10, with complete therapy (the Emoxipin in/m, the Piracetam in/in, the medication parabulbarno). Then, the patients received 1 tablet 2 times daily (20 mg) within 25 days as the monotherapy with local hypotensive drops (timolol, azopt, azarga, fotil, cosopt, alphagan P). Intraocular pressure compensation was achieved by timolol 0,5% dropping (45 eyes), azopt dropping (28 eyes), alphagan P dropping (6 eyes) and by means of combination drugs: azarga (32 eyes), cosopt (15 eyes) and fotil (4 eyes). Of them, in 52 eyes surgical treatment was made. The control group consisted of 30 patients (60 eyes), who received the treatment without the Neuromidin. In work the authors used the standard methods of ophthalmic research. The increase of visual acuity and expansion of field of view in both groups was revealed, but in the patients treated by means of the Neuromidin
the visual acuity increased in advanced 0.13, in patients with severe degree of disease – in 0.12, in the control group – in 0.06 and 0,05, respectively . Field of view has expanded in an advanced stage of 55 degrees, and in severe – 35 degrees higher than in the control group. The Neuromidin effect on the state of the outflow of aqueous humor was revealed. This effect can be explained by the fact that the drug stimulates the impulse conduction in nerve fibers and synapses, blocks of cholinesterase, stimulates the ciliary muscle and activation of the outflow watery
moisture. The achieved effect gradually decreases to the initial indicators within 6 months in 2/3 patients.