scholarly journals Riluzole and ranolazine application of prostate cancer: Cancer related testicular and liver tissue damage

2022 ◽  
Vol 5 (1) ◽  
pp. 10-22
Author(s):  
Pinar Koroglu Aydin ◽  
Ilknur Bugan
Keyword(s):  
Prostate Cancer ◽  
Tissue Damage ◽  
Liver Tissue

scholarly journals Pemulihan Kerusakan Jaringan Hati Mencit yang Diberi Ekstrak Butanol Buah Tua Mahkota Dewa

2018 ◽  
Vol 10 (1) ◽  
pp. 53
Author(s):  
Arif Soeksmanto
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Medicinal Plant ◽  
Traditional Medicine ◽  
Tissue Damage ◽  
Liver Tissue ◽  
Butanol Extract ◽  
Phaleria Macrocarpa ◽  
Almost All

Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.) is an Indonesians traditional medicinal plant used to treat various diseases, such as diabetes mellitus, hemorrhoid, impotency and cancer. Almost all parts of the plants canbe used as traditional medicine, but if directly consumed, it can cause swollen, sprue, numb at tongue, fever, even unconsciousness. This research was carried out to find out recovery of liver tissue damage of mice administered intraperitoneally with subchronic dosage of butanol extract 170 mg/kg body weight. Observation on first week showed that there is light degeneration (vacuolization) which is getting better on second week and apparentlynormal on forth week.

Liver tissue damage by ultrasound in combination with the photosensitizing drug, Photofrin II

1994 ◽  
Vol 78 (1-3) ◽  
pp. 177-181 ◽  
Author(s):  
Katsuro Tachibana ◽  
Kouichi Sugata ◽  
Jing Meng ◽  
Makoto Okumura ◽  
Shunro Tachibana
Keyword(s):  
Tissue Damage ◽  
Liver Tissue ◽  
Photofrin Ii

Metformin protects against diabetes–induced heart injury and dunning prostate cancer model

2020 ◽  
pp. 096032712094745
Author(s):  
BB Bayrak ◽  
P Koroglu ◽  
O Karabulut Bulan ◽  
R Yanardag
Keyword(s):  
Prostate Cancer ◽  
Tissue Damage ◽  
Total Antioxidant Status ◽  
Experimental Period ◽  
Heart Tissue ◽  
Diabetic Rats ◽  
Control Group ◽  
Cancer Group ◽  
Total Antioxidant

In this study, both diabetes and Dunning prostate cancer were induced for the first time in Copenhagen rats in vivo. Thus, the effects of metformin against heart tissue damage of these rats were investigated by biochemical methods. Dunning prostate cancer was induced in Copenhagen rats using high metastatic MAT-LyLu cells. The rats were divided as follows: Control group: only injected with 0.9% NaCl for 14 days; Diabetic group: only injected single dose of streptozotocin (STZ) (65 mg/kg); Cancer group: subcutaneously (s.c) inoculated with 2 x 104 MAT-LyLu cells only; Diabetic + cancer (DC) group: inoculated with 2 x 104 MAT-LyLu cells and STZ injection, Cancer + metformin (CM) group: injected with metformin for 14 days after Mat-LyLu cells application; Diabetic + cancer + metformin (DCM) group: metformin administered for 14 days together with STZ and Mat-LyLu cells. At the end of the experimental period, heart tissues were taken. Reduced glutathione and total antioxidant status levels in heart tissues were decreased, whereas lipid peroxidation, advanced oxidized protein products, nitric oxide, homocysteine, and reactive oxygen species levels, total oxidant status and catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and xanthine oxidase activities increased in the diabetic, cancer and DC groups. Treatment with metformin reversed these effects. In conclusion, the present study shows that metformin has a protective effect against heart tissue damage in STZ-induced diabetic rats with Dunning prostate cancer.

Brilliant blue G protects against brain and liver tissue damage during systemic endotoxemia in rats treated with lipopolysaccharide

2019 ◽  
Vol 28 (5) ◽  
pp. 1331-1344
Author(s):  
Omar M. E. Abdel-Salam ◽  
Amany A. Sleem ◽  
Nadia A. Mohammed ◽  
Eman R. Youness ◽  
Noha N. Yassen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Liver Tissue ◽  
Brilliant Blue ◽  
Brilliant Blue G ◽  
Systemic Endotoxemia

Histopathologic Study on Liver Tissue Damage after Injection of Various Contrast Materials into the Liver Parenchyma of Rat

1995 ◽  
Vol 32 (2) ◽  
pp. 291
Author(s):  
Sung Hoon Chung ◽  
Goo Lee ◽  
Sun Ae Chang ◽  
Joon Hee Joh ◽  
Hyeon Gon Lee ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Liver Tissue ◽  
Liver Parenchyma ◽  
Histopathologic Study ◽  
Contrast Materials

scholarly journals Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769594 ◽  
Author(s):  
Seung S Lee ◽  
Philip JR Roche ◽  
Paresa N Giannopoulos ◽  
Elliot J Mitmaker ◽  
Michael Tamilia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Tissue Damage ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Cell Ablation ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Specific Membrane

Almost all biological therapeutic interventions cannot overcome neoplastic heterogeneity. Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. Multi-walled carbon nanotubes offer a number of unique properties: chemical stability, photonic properties including efficient light absorption, thermal conductivity, and extensive surface area availability for covalent chemical ligation. When combined together with a targeting moiety such as an antibody or small molecule, one can deliver highly localized temperature increases and cause extensive cellular damage. We have functionalized multi-walled carbon nanotubes by conjugating an antibody against prostate-specific membrane antigen. In our in vitro studies using prostate-specific membrane antigen–positive LNCaP prostate cancer cells, we have effectively demonstrated cell ablation of >80% with a single 30-s exposure to a 2.7-W, 532-nm laser for the first time without bulk heating. We also confirmed the specificity and selectivity of prostate-specific membrane antigen targeting by assessing prostate-specific membrane antigen–null PC3 cell lines under the same conditions (<10% cell ablation). This suggests that we can achieve an extreme nearfield cell ablation effect, thus restricting potential tissue damage when transferred to in vivo clinical applications. Developing this new platform will introduce novel approaches toward current therapeutic modalities and will usher in a new age of effective cancer treatment squarely addressing tumoral heterogeneity.

scholarly journals GAMBARAN HISTOPATOLOGI HATI TIKUS WISTAR (Rattus norvegicus) PASCA PEMBERIAN MONOSODIUM GLUTAMAT

2019 ◽  
Vol 10 (01) ◽  
pp. 68-75
Author(s):  
Angga Baskara ◽  
I.N. Arsana ◽  
N.K.A. Juliasih
Keyword(s):  
Statistical Analysis ◽  
Liver Damage ◽  
Tissue Damage ◽  
Rattus Norvegicus ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Detrimental Effect ◽  
Monosodium Glutamate ◽  
Liver Histopathology ◽  
Paraffin Method

Monosodium glutamate (MSG) has been used very widely in the community as a food flavoring, and is thought to have a detrimental effect. This study aims to determine the effect of MSG on liver histopathology. 28 Wistar rats were used in this study. Rats were grouped into four groups: control (K), MSG-1 (MSG dose 1.5 mg / g bodyweight), MSG-2 (MSG dose 3.5 mg / g bw), and MSG-3 (MSG dose 4, 5 mg / g bw). MSG is given every day for 30 days. At the end of the treatment, the rat were euthanized and dissected for taking the liver. Histology preparation were made using the paraffin method and stained with Hematoxyclin Eosin (HE) staining. Kruskal Wallis and Mann Whitney test were used for statistical analysis. The results showed that the dose of MSG was 1.5; 3; and 4.5 mg / g bw causes liver damage with the same level of damage in the form of focused degeneration in one place. The higher the dose, the more degeneration of focused on one place which were found. Liver tissue damage scores in group K, MSG-1, MSG-2, and MSG-3 were 0; 0.4; 0.42857, and 0.45714. Conclusion, the administration of MGS has an effect on liver histopathology.

Molecular basis of protective effect by crocetin on survival and liver tissue damage following hemorrhagic shock

2005 ◽  
Vol 278 (1-2) ◽  
pp. 139-146 ◽  
Author(s):  
Animesh Dhar ◽  
George Cherian ◽  
Gopal Dhar ◽  
Gibanananda Ray ◽  
Ram Sharma ◽  
...  
Keyword(s):  
Protective Effect ◽  
Hemorrhagic Shock ◽  
Tissue Damage ◽  
Liver Tissue ◽  
Molecular Basis
Sign in / Sign up

Export Citation Format

Share Document