scholarly journals Influence of non-thermal argon plasma needle on blood coagulation

2019 ◽  
Vol 14 (29) ◽  
pp. 101-106
Author(s):  
Kadhim A. Aadim
Keyword(s):  
Blood Coagulation ◽  
Power Supply ◽  
Atmospheric Pressure ◽  
Argon Plasma ◽  
Experimental Setup ◽  
Argon Gas ◽  
Ac Power ◽  
Plasma Needle ◽  
Electric Component ◽  
Non Thermal Plasma

Non-thermal argon plasma needle at atmospheric pressure wasconstructed. The experimental setup was based on a simple and lowcost electric component that generates a sufficiently high electricfield at the electrodes to ionize the argon gas which flow atatmospheric pressure. A high AC power supply was used with 1.1kV and 19.57 kHz. Non-thermal Argon plasma used on bloodsamples to show the ability of non-thermal plasma to promote bloodcoagulation. Three tests have been done to show the ability of plasmato coagulate both normal and anti-coagulant blood. Each bloodsample has been treated for varying time from 20sec. to 180sec. atdifferent distances. The results of the current study showed that thecold plasma produced from argon significantly increase the in vitrospeed of blood coagulation, the plasma increases activation andaggregation of platelets, causes proliferation of fibroblasts and fibrinproduction accelerates blood coagulation.

The Research of Atmospheric Pressure Cold Plasma Jet Generated by Auto-Excited-Pulsed DC Discharge

2014 ◽  
Vol 989-994 ◽  
pp. 1200-1203
Author(s):  
Ye Lin Hu ◽  
Qiu Wang ◽  
Zhao Quan Chen
Keyword(s):  
Power Supply ◽  
Discharge Current ◽  
Atmospheric Pressure ◽  
Cold Plasma ◽  
Argon Plasma ◽  
Plasma Jet ◽  
Pulse Frequency ◽  
Dc Discharge ◽  
Pulsed Dc ◽  
Piezoelectric Ceramic Transformer

In order to obtain stable cold plasma jet under atmospheric pressure condition, we designed a high-voltage DC power supply based on the principle of multilayer piezoelectric ceramic transformer (MPT). At the same time, we developed a cold plasma jet device that its shape is similar to the gun structure. The total weight of device, including the power supply and the generator, is less than 500 g. In the experiments of argon plasma under atmospheric pressure, current–voltage measurements show that the discharge actually appears periodically pulsed with a frequency of about 30 kHz. The discharge current has a pulse-width that is about 100 ns, while its peak value reaches about 32 mA. The maximum length of the plasma is about 3 cm. The further study showed that the discharge current pulse frequency is determined by the ion drift mechanism.

scholarly journals The influence of argon gas flow in the killing of staphylococcus epidermidis bacteria

2018 ◽  
Vol 16 (36) ◽  
pp. 134-139
Author(s):  
Ahmed Mahmoud Shihab
Keyword(s):  
Staphylococcus Epidermidis ◽  
Atmospheric Pressure ◽  
Gas Flow ◽  
Biotechnological Applications ◽  
Plasma System ◽  
Argon Gas ◽  
Killing Rate ◽  
Normal Atmospheric Pressure ◽  
Non Thermal Plasma

In this research, non-thermal plasma system of argon gas is designed to work at normal atmospheric pressure and suitable for work in medical and biotechnological applications. This technique is applied in the treatment of the Staphylococcus epidermidis bacteria and show the role of the flow rate of Argon gas on the killing rate of bacteria, and it obtained a 100 % killing rate during the time of 5 minutes at the flow Argon gas of 5 liters/ min.

scholarly journals Plasma Needles on the Teeth Structure and Compressibility

2016 ◽  
Vol 2 (4) ◽  
Author(s):  
Mohammed U. Hussein
Keyword(s):  
Atmospheric Pressure ◽  
Treatment Time ◽  
Mechanical Damage ◽  
Argon Plasma ◽  
Load Force ◽  
Plasma Exposure ◽  
Negative Results ◽  
Plasma Needle ◽  
Jet Plasma ◽  
Different Gases

The aim from this research  is  to prove not affected the teeth of both damage macroscopic and  the internal structure of teeth (compressibility). The teeth were collected from (Al karama dental specialized) in Baghdad, directly after uprooted from the patient's mouth. It was in table by the material (normal saline, sodium chloride, 0.9%), according to instructions of dental disease specialist. It was regarded as a natural model replica. It has been conducted two tests on some samples: studying the macroscopic damage for teeth and studying the influence compressibility for teeth. The design of generation argon plasma needle   system, this system works on production Non- thermal plasma at atmospheric pressure, where used simples electronics constructions and cost low, it has power   to generate high electric field on electrodes enough to ionize different gases and flow in atmospheric pressure. The device jet plasma needle used  surely from  no events any  macroscopic or mechanical damage in build inside teeth (compressibility) ,where it applied  on some teeth sample at time double treatment time ,then teeth check  consequently  favorableness result ,where load  force of tooth without  plasma exposure  was 1.74kN while load  force of tooth with   plasma exposure  was 1.824kN.Studying the macroscopic damage for teeth, the mentioned area were not affected with damage or change colors, therefore in effecting the teeth with any negative results during plasma needle process.

Development of an atmospheric pressure non-thermal plasma needle for melanoma cell research

2009 ◽  
Author(s):  
Jennifer L. Zirnheld ◽  
Thomas M. DiSanto ◽  
Kevin M. Burke ◽  
Shoshanna N. Zucker ◽  
Kasra Etemadi
Keyword(s):  
Melanoma Cell ◽  
Thermal Plasma ◽  
Atmospheric Pressure ◽  
Plasma Needle ◽  
Non Thermal Plasma

scholarly journals Electrical, thermal and optical characteristics of plasma torch

2019 ◽  
Vol 13 (27) ◽  
pp. 151-156
Author(s):  
Ali A-K. Hussain
Keyword(s):  
Atmospheric Pressure ◽  
Gas Flow ◽  
Low Cost ◽  
Argon Plasma ◽  
Maximum Value ◽  
Gas Plasma ◽  
Ac Power ◽  
Set Up ◽  
Ar Gas ◽  
Plasma Electrode

Non thermal argon plasma needle at atmospheric pressure was constructed. The experimental set up was based on simple and low cost electric components that generate electrical field sufficiently high at the electrodes to ionize various gases which flow at atmospheric pressure. A high AC power supply was used with 9.6kV peak to peak and 33kHz frequency. The plasma was generated using two electrodes. The voltage and current discharge waveform were measured. The temperature of Ar gas plasma jet at different gas flow rate and distances from the plasma electrode was also recorded. It was found that the temperature increased with increasing frequency to reach the maximum value at 15 kHz, and that the current leading the voltage, which demonstrates the capacitive character of the discharge. The electron temperature was measured at about 0.61 eV, and we calculated the electron number density to be 4.38×1015 cm-3.

scholarly journals The study of thermal description for non-thermal plasma needle system

2018 ◽  
Vol 16 (36) ◽  
pp. 66-72
Author(s):  
Ahmed Mahmoud Shihab
Keyword(s):  
Low Temperature ◽  
Thermal Plasma ◽  
Applied Voltage ◽  
Atmospheric Pressure ◽  
Cold Plasma ◽  
Plasma Temperature ◽  
Temperature Decrease ◽  
Plasma System ◽  
Plasma Needle ◽  
Non Thermal Plasma

Cold plasma is a relatively low temperature gas, so this feature enables us to use cold plasma to treat thermally sensitive materials including polymers and biologic tissues. In this research, the non-thermal plasma system is designed with diameter (3 mm, 10 mm) Argon at atmospheric pressure as well as to be suitable for use in medical and biotechnological applications.The thermal description of this system was studied and we observed the effect of the diameter of the plasma needle on the plasma, when the plasma needle slot is increased the plasma temperature decrease, as well as the effect of the voltages applied to the temperature of the plasma, where the temperature increasing with increasing the applied voltage . Results showed that the plasma temperature would be low, which enables the use of this system in many medical aspects.

Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3162-3162 ◽  
Author(s):  
Gayathri Nagaraj ◽  
Manjula Balasubramanian ◽  
Sameer Kalghatgi ◽  
Andrew S. Wu ◽  
Ari D. Brooks ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Platelet Activation ◽  
Thermal Plasma ◽  
Atmospheric Pressure ◽  
Discharge Plasma ◽  
Barrier Discharge ◽  
Dielectric Barrier Discharge Plasma ◽  
Dielectric Barrier ◽  
Barrier Discharge Plasma ◽  
Non Thermal Plasma

Abstract Introduction: Non-thermal atmospheric pressure dielectric barrier discharge plasma (cold plasma due to its non-thermal nature) has emerged as a promising new tool in medicine due to its ability to coagulate blood rapidly, sterilize tissue without thermal damage and induce apoptosis in malignant tissue. The potential clinical applicability of non-thermal plasma lies in its use in controlling intra-operative microvascular bleeding in organs and in endoscopy. Non-thermal plasma can also be used to treat superficial wounds in trauma through hemostasis while simultaneously inducing surface sterilization. We have previously demonstrated that non-thermal plasma hastens blood coagulation on cut tissue surfaces and accelerates clot formation in whole blood five times faster than natural coagulation. A series of experiments were undertaken to investigate the mechanism of coagulation by non-thermal plasma. Methods/Results: We initially postulated that changes in pH and/or extracellular Ca2+ as a possible mechanism for non-thermal plasma mediated coagulation. Our studies however showed no significant changes in pH or Ca2+ in treated blood. Thermal energy triggered coagulation as seen in conventional electrocautery as well as electric field effects were eliminated as other possible mechanisms. The role of reactive oxygen species (ROS) in coagulation was studied, as non-thermal plasma is known to produce ROS in water. ROS production in blood was blocked with sodium pyruvate, an ROS scavenger, and the results showed no effect on non-thermal plasma induced coagulation. Specific effects of non-thermal plasma on citrated blood samples revealed extremely rapid coagulation with surface gel formation, while clotting studies (PT, aPTT) performed on the plasma beneath the gel revealed consumption of coagulation factors. Examination of the clot formed by non-thermal plasma using Scanning Electron Microscopy (SEM) showed platelet activation with pseudopodia formation, aggregation, and fibrin formation. The effects of non-thermal plasma on fibrinogen solution treated at physiologic pH showed a change in opacity suggesting clot formation. Dynamic Light Scattering (DLS) was used to measure particle size distributions of treated and untreated fibrinogen solutions. Treated fibrinogen exhibited a multi-modal distribution of sizes with the largest size corresponding to the size of fibrin-like structures. This suggests that non-thermal plasma may coagulate blood by the conversion of fibrinogen to fibrin. Evaluation of albumin, our control protein given its non-involvement in coagulation, showed no changes upon exposure to non-thermal plasma. Conclusion: Non-thermal plasma likely promotes coagulation by enhancing the physiologic coagulation process through direct activation of fibrinogen as well as platelet activation and aggregation. Future research will further evaluate the mechanisms of non-thermal plasma induced platelet activation and effects on other proteins in the coagulation cascade. This will lead to newer insights into the physiological aspects of coagulation and clinical utility of non-thermal plasma in medicine.

scholarly journals Effect of an Argon Plasma Produced At The Atmospheric Pressure On Blood Coagulation And Wounds Healing

2017 ◽  
Vol 12 (03) ◽  
pp. 27-34
Author(s):  
Hamid H. Murbat ◽  
Feza Shalal ◽  
Neda Neda ◽  
Neean F. Mageed ◽  
Raghda H. Hassan ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Atmospheric Pressure ◽  
Argon Plasma
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