Association of Alcohol Intake and Fracture Risk in Elderly Varied by Affected Bones: A Nationwide Longitudinal Study

Objective Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly subjects and further analyzed whether the association varied by fracture locations.Methods This is a nationwide population-based cohort study which included all people aged 66 (n=1,431,539) receiving the National Screening Program during 2009–2014. Time-to-event were defined as duration from study recruitment, the day they received health screening, to the occurrence of fracture.Results Total fracture was significantly lower in mild drinkers [adjusted hazard ratio (aHR)=0.952; 95% confidence interval (95% CI) =0.931–0.973] and higher in heavy drinkers (aHR=1.246; 95% CI=1.201–1.294) than non-drinkers. Risk pattern of alcohol consumption and fracture differed according to affected bones. Similar J-shaped trends were observed for vertebra fractures, but risk of limb fracture showed a linear relationship with alcohol intake. For hip fracture, risk decrement was more pronounced in mild and moderate drinkers, and significant increment was noted only in very severe drinkers [≥60 g/day; (aHR)=1.446; 1.162–1.801].Conclusion Light to moderate drinking generally lowered risk of fractures, but association between alcohol and fracture risk varied depending on the affected bone lesions.

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Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study

Public Health Nutrition ◽

10.1017/s136898000000029x ◽

2000 ◽

Vol 3 (3) ◽

pp. 253-261 ◽

Cited By ~ 30

Author(s):

Solveig A Hansen ◽

Aaron R Folsom ◽

Lawrence H Kushi ◽

Thomas A Sellers

Keyword(s):

Fracture Risk ◽

Alcohol Intake ◽

Proportional Hazards ◽

Positive Association ◽

Population Based ◽

Fracture Site ◽

Cox Proportional Hazards ◽

Health Study ◽

Caffeine Intake ◽

Upper Arm

AbstractObjectiveTo assess whether alcoholic and caffeinated beverages are associated with risk of fractures in women.SettingPopulation-based sample surveyed by post.SubjectsA total of 34703 postmenopausal Iowan women aged 55–69 years were surveyed.DesignA cohort of women reported alcoholic and caffeinated beverage intake and were followed for 6.5 years for fracture occurrence. Relative risks (RR) and 95% confidence intervals (CI) were computed using Cox proportional hazards regression. Covariates included age, tobacco use, physical activity, body mass index (BMI), waist to hip ratio (WHR), oestrogen use and calcium intake.ResultsAt least one fracture was reported by 4378 women (389 upper arm, 288 forearm, 1128 wrist, 275 hip, 416 vertebral and 2920 other fractures). The adjusted RR for highest versus lowest caffeine intake quintiles was 1.09 (95% CI 0.99–1.21) for combined fracture sites. Wrist fractures were associated positively (RR for extreme quintiles 1.37, 95% CI 1.11–1.69) and upper arm fractures were negatively associated (RR 0.67, 95% CI 0.48–0.94) with caffeine intake. The age-adjusted RR of total fractures for highest versus lowest frequency of beer usage was 1.55 (95% CI 1.25–1.92) and for liquor was 1.25 (95% CI 1.03–1.54). No other association was found between any specific fracture site and alcohol intake.ConclusionsWe found a modest increase in fracture risk associated with highest caffeine intake, varying by site. Alcohol intake was low, but it also showed a weak positive association with fracture risk.

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Determinants of Participation and Detection Rate of Upper Gastrointestinal Cancer from Population-Based Screening Program in China

SSRN Electronic Journal ◽

10.2139/ssrn.3381137 ◽

2019 ◽

Author(s):

Lanwei Guo ◽

Shaokai Zhang ◽

Shuzheng Liu ◽

Liyang Zheng ◽

Qiong Chen ◽

...

Keyword(s):

Gastrointestinal Cancer ◽

Detection Rate ◽

Screening Program ◽

Population Based ◽

Upper Gastrointestinal Cancer ◽

Upper Gastrointestinal

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Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity

Journal of Personalized Medicine ◽

10.3390/jpm11060497 ◽

2021 ◽

Vol 11 (6) ◽

pp. 497

Author(s):

Yoonsuk Jung ◽

Eui Im ◽

Jinhee Lee ◽

Hyeah Lee ◽

Changmo Moon

Keyword(s):

Colorectal Cancer ◽

Large Scale ◽

Screening Program ◽

Antiplatelet Agents ◽

Population Based ◽

Small Sample ◽

Antithrombotic Agents ◽

Predictive Values ◽

Prescription Rates ◽

Small Sample Sizes

Previous studies have evaluated the effects of antithrombotic agents on the performance of fecal immunochemical tests (FITs) for the detection of colorectal cancer (CRC), but the results were inconsistent and based on small sample sizes. We studied this topic using a large-scale population-based database. Using the Korean National Cancer Screening Program Database, we compared the performance of FITs for CRC detection between users and non-users of antiplatelet agents and warfarin. Non-users were matched according to age and sex. Among 5,426,469 eligible participants, 768,733 used antiplatelet agents (mono/dual/triple therapy, n = 701,683/63,211/3839), and 19,569 used warfarin, while 4,638,167 were non-users. Among antiplatelet agents, aspirin, clopidogrel, and cilostazol ranked first, second, and third, respectively, in terms of prescription rates. Users of antiplatelet agents (3.62% vs. 4.45%; relative risk (RR): 0.83; 95% confidence interval (CI): 0.78–0.88), aspirin (3.66% vs. 4.13%; RR: 0.90; 95% CI: 0.83–0.97), and clopidogrel (3.48% vs. 4.88%; RR: 0.72; 95% CI: 0.61–0.86) had lower positive predictive values (PPVs) for CRC detection than non-users. However, there were no significant differences in PPV between cilostazol vs. non-users and warfarin users vs. non-users. For PPV, the RR (users vs. non-users) for antiplatelet monotherapy was 0.86, while the RRs for dual and triple antiplatelet therapies (excluding cilostazol) were 0.67 and 0.22, respectively. For all antithrombotic agents, the sensitivity for CRC detection was not different between users and non-users. Use of antiplatelet agents, except cilostazol, may increase the false positives without improving the sensitivity of FITs for CRC detection.

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A population-based investigation of the association between alcohol intake and serum total ghrelin concentrations among cigarette-smoking, non-alcohol-dependent male individuals

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2021.108835 ◽

2021 ◽

pp. 108835

Author(s):

Mehdi Farokhnia ◽

Gwen Murphy ◽

Stephanie J. Weinstein ◽

Navan N. Shah ◽

Dominick Parisi ◽

...

Keyword(s):

Cigarette Smoking ◽

Alcohol Intake ◽

Population Based ◽

Total Ghrelin ◽

Alcohol Dependent

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Frequency of the delta Phe508 mutation and correlation with XV.2c/KM-19 haplotypes in an American population of cystic fibrosis patients: results of a collaborative study

Clinical Chemistry ◽

10.1093/clinchem/36.10.1741 ◽

1990 ◽

Vol 36 (10) ◽

pp. 1741-1746 ◽

Cited By ~ 10

Author(s):

W E Highsmith ◽

G L Chong ◽

H T Orr ◽

T R Perry ◽

D Schald ◽

...

Keyword(s):

Cystic Fibrosis ◽

Haplotype Analysis ◽

Screening Program ◽

Collaborative Study ◽

Population Based ◽

Carrier Status ◽

Chain Reaction ◽

Polymerase Chain ◽

Phenylalanine Residue ◽

Test Result

Abstract The cystic fibrosis (CF) gene has been recently cloned, and a deletion of 3 basepairs (bp) of DNA was found on most of the CF chromosomes. This deletion leads to the synthesis of a protein that lacks a phenylalanine residue at position 508. Using two polymerase chain reaction protocols to study the frequency of this mutation in a series of 192 CF patients, we found the mutation on 72% of affected chromosomes. We then used this value to calculate the predictive value of a negative test result in a population-based screening program for CF carrier status. Haplotype analysis with the polymorphic markers XV.2c and KM-19 on 239 CF chromosomes revealed that 90.7% of CF chromosomes with the deletion had a single haplotype. This haplotype was also associated with 60.4% of CF chromosomes with unknown mutations. These values can be used to calculate the probability of whether an individual from the general population is a carrier of any CF mutation.

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Role of community pharmacies in a population-based colorectal cancer screening program

Preventive Medicine ◽

10.1016/j.ypmed.2021.106420 ◽

2021 ◽

pp. 106420

Author(s):

Nuria Vives ◽

Núria Milà ◽

Gemma Binefa ◽

Noemie Travier ◽

Albert Farre ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Screening ◽

Colorectal Cancer Screening ◽

Screening Program ◽

Population Based ◽

Community Pharmacies ◽

Cancer Screening Program

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In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age

Scientific Reports ◽

10.1038/s41598-020-80904-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jungsoo Chae ◽

Geum Joon Cho ◽

Min-Jeong Oh ◽

KeonVin Park ◽

Sung Won Han ◽

...

Keyword(s):

National Health ◽

Screening Program ◽

Hazard Analysis ◽

Population Based ◽

In Utero ◽

National Database ◽

Rank Test ◽

In Utero Exposure ◽

Exposure Group ◽

Increased Risk

AbstractBeta-2 adrenergic receptor (B2AR) agonists, used as asthma treatments and tocolytics during pregnancy, have recently been reported to be associated with autism in their offspring. However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolytics, has never been substantiated with any nationwide database. Thus, we aimed to examine the association between in utero exposure of ritodrine and the risk of autism in their offspring using a national database. This population-based cohort study was conducted by merging the Korea National Health Insurance claims database and National Health Screening Program for Infants and Children database. These databases included all women who had delivered singleton between January 2007 and December 2008 in Korea. Out of the total 770,016 mothers, 30,959 (4.02%) were exposed to ritodrine during pregnancy, and 5583 (0.73%) of their children were identified as having autism, defined until 8 years of age. According to our analysis, the overall cumulative incidence of autism up to 8 years was 1.37% in ritodrine exposure group and 0.70% in ritodrine non-exposure group (p < 0.05, log-rank test). By Cox proportional hazard analysis, use of ritodrine in preterm birth was associated with significantly higher hazard of autism [adjusted hazard ratio: 1.23, 95% CI 1.04–1.47], after adjusting for confounding variables including maternal age, parity, cesarean section, preterm labor, steroid use, birth weight, gender, and preeclampsia. Thus, in utero exposure to ritodrine was associated with an increased risk of autism in their offspring.

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Using hemoccult sensa in a population-based colorectal cancer screening program in Israel

European Journal of Cancer ◽

10.1016/0959-8049(93)91129-9 ◽

1993 ◽

Vol 29 ◽

pp. S95

Author(s):

G. Rennert

Keyword(s):

Colorectal Cancer ◽

Cancer Screening ◽

Colorectal Cancer Screening ◽

Screening Program ◽

Population Based ◽

Cancer Screening Program

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Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2015-0068 ◽

2016 ◽

Vol 54 (1) ◽

Cited By ~ 9

Author(s):

Raimund Pechlaner ◽

Stefan Kiechl ◽

Manuel Mayr ◽

Peter Santer ◽

Siegfried Weger ◽

...

Keyword(s):

Cardiovascular Disease ◽

Alcohol Intake ◽

Carotid Atherosclerosis ◽

Blood Parameters ◽

Population Based ◽

Dietary Intakes ◽

Iron Stores ◽

Serum Hepcidin ◽

General Community ◽

Incident Cardiovascular Disease

AbstractThe expression of the key iron regulatory hormone hepcidin is regulated by iron availability, inflammation, hormones, hypoxia, and anaemia. Increased serum concentrations of hepcidin have recently been linked to atherosclerosis. We studied demographic, haematologic, biochemical, and dietary correlates of serum hepcidin levels and its associations with incident cardiovascular disease and with carotid atherosclerosis.Serum hepcidin concentrations were measured by tandem mass spectrometry in samples taken in 2000 from 675 infection-free participants of the prospective population-based Bruneck study (age, mean±standard deviation, 66.0±10.2; 48.1% male). Blood parameters were measured by standard methods. Dietary intakes of iron and alcohol were surveyed with a food frequency questionnaire. Carotid atherosclerosis (365 cases) was assessed by ultrasound and subjects were observed for incident stroke, myocardial infarction, or sudden cardiac death (91 events) until 2010.Median (interquartile range) hepcidin levels were 2.27 nM (0.86, 4.15). Most hepcidin correlates were in line with hepcidin as an indicator of iron stores. Independently of ferritin, hepcidin was related directly to physical activity (p=0.024) and fibrinogen (p<0.0001), and inversely to alcohol intake (p=0.006), haemoglobin (p=0.027), and γ-glutamyltransferase (p<0.0001). Hepcidin and hepcidin-to-ferritin ratio were not associated with prevalent carotid atherosclerosis (p=0.43 and p=0.79) or with incident cardiovascular disease (p=0.62 and p=0.33).In this random sample of the general community, fibrinogen and γ-glutamyltransferase were the most significant hepcidin correlates independent of iron stores, and hepcidin was related to neither atherosclerosis nor cardiovascular disease.

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