Depression, Anxiety, Related Risk Factors and Cognitive Distortion in Korean Patients with Inflammatory Bowel Disease

Objective To evaluate the severity of depression, anxiety, associated risk factors, and cognitive distortion in Korean patients with ulcerative colitis (UC) and Crohn’s disease (CD).Methods This study included 369 patients with inflammatory bowel disease. The severity of depression and anxiety was examined using Patient Health Questionnaire-9 and Hospital Anxiety and Depression Scale. The Anxious Thoughts and Tendencies scale was used to measure catastrophizing tendency. Multivariate regression analyses were performed.Results The predictors of depression were marital status, anti-tumor necrosis factor-α (TNF-α) agent use, age, and body mass index in UC patients and marital status, disease activity, alcohol use, and employment status in CD patients. For anxiety, sex and marital status were the associated factors in UC patients, whereas steroid use was the only significant predictor in CD patients. Comparing the cognitive distortion level, there were no significant differences between UC and CD patients although there was an increasing tendency according to the severity of depression or anxiety.Conclusion If patients are accompanied by high levels of depression or anxiety and their associated risk factors including TNF-α agent or steroid use, it is recommended that not only symptoms are treated but also cognitive approach and evaluation be performed.

Download Full-text

P124. Systematic review of the impact of psychological morbidity and associated risk factors in young people with inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjw019.243 ◽

2016 ◽

Vol 10 (suppl 1) ◽

pp. S151.2-S151

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Inflammatory Bowel Disease ◽

Young People ◽

Bowel Disease ◽

Psychological Morbidity ◽

Inflammatory Bowel ◽

Associated Risk Factors ◽

The Impact

Download Full-text

Biologic-Induced Infections in Inflammatory Bowel Disease: The TNF-α Antagonists

Annals of Pharmacotherapy ◽

10.1177/1060028018754896 ◽

2018 ◽

Vol 52 (6) ◽

pp. 571-579 ◽

Cited By ~ 4

Author(s):

Sean M. McConachie ◽

Sheila M. Wilhelm ◽

Ashish Bhargava ◽

Pramodini B. Kale-Pradhan

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Opportunistic Infections ◽

Case Series ◽

Infectious Risk ◽

Increased Risk ◽

Tnf Α ◽

Inflammatory Bowel ◽

Meta Analyses

Objective: To review the mechanism and association of infectious risk among the tumor-necrosis factor α (TNF-α) antagonists used in inflammatory bowel disease. Data Sources: A PubMed literature search was performed using the following search terms: infliximab, adalimumab, certolizumab, golimumab, inflammatory bowel disease, crohn’s, ulcerative colitis, adverse effects, adverse events, safety, and infection. Study Selection and Data Extraction: Meta-analyses and cohort studies with outcomes pertaining to quantitative infectious risk were reviewed. Case reports and case series describing association between TNF-α inhibitors and infection were also reviewed. Data Synthesis: A total of 7 recent meta-analyses of randomized trials demonstrate inconclusive association of infection with TNF-α antagonists. Registry data suggest that medications carry an independent risk of opportunistic infections. Risk factors for infection include older age, malnutrition, diabetes, and possibly combination therapy. Reported infections vary widely but include intracellular and granulomatous bacteria, viruses, and fungi. Conclusion: TNF-α antagonists are associated with an increased risk of opportunistic infection, although this risk has not been demonstrated conclusively in randomized controlled trials. Knowledge of concomitant risk factors, mechanism of infectious risk, and available treatment options can improve patient care in the clinical setting.

Download Full-text