Human nucleus accumbens facilitates memory formation in the hippocampus

2007 ◽  
pp. 227-228
2006 ◽  
Vol 32 (1) ◽  
pp. 93-97 ◽  
Author(s):  
L. Ramirez-Lugo ◽  
L. Nunez-Jaramillo ◽  
F. Bermudez-Rattoni

2015 ◽  
Vol 112 (36) ◽  
pp. 11383-11388 ◽  
Author(s):  
Takashi Yamaguchi ◽  
Akihiro Goto ◽  
Ichiro Nakahara ◽  
Satoshi Yawata ◽  
Takatoshi Hikida ◽  
...  

The nucleus accumbens (NAc) serves as a key neural substrate for aversive learning and consists of two distinct subpopulations of medium-sized spiny neurons (MSNs). The MSNs of the direct pathway (dMSNs) and the indirect pathway (iMSNs) predominantly express dopamine (DA) D1 and D2 receptors, respectively, and are positively and negatively modulated by DA transmitters via Gs- and Gi-coupled cAMP-dependent protein kinase A (PKA) signaling cascades, respectively. In this investigation, we addressed how intracellular PKA signaling is involved in aversive learning in a cell type-specific manner. When the transmission of either dMSNs or iMSNs was unilaterally blocked by pathway-specific expression of transmission-blocking tetanus toxin, infusion of PKA inhibitors into the intact side of the NAc core abolished passive avoidance learning toward an electric shock in the indirect pathway-blocked mice, but not in the direct pathway-blocked mice. We then examined temporal changes in PKA activity in dMSNs and iMSNs in behaving mice by monitoring Förster resonance energy transfer responses of the PKA biosensor with the aid of microendoscopy. PKA activity was increased in iMSNs and decreased in dMSNs in both aversive memory formation and retrieval. Importantly, the increased PKA activity in iMSNs disappeared when aversive memory was prevented by keeping mice in the conditioning apparatus. Furthermore, the increase in PKA activity in iMSNs by aversive stimuli reflected facilitation of aversive memory retention. These results indicate that PKA signaling in iMSNs plays a critical role in both aversive memory formation and retention.


Neuron ◽  
2010 ◽  
Vol 65 (4) ◽  
pp. 541-549 ◽  
Author(s):  
Nikolai Axmacher ◽  
Michael X. Cohen ◽  
Juergen Fell ◽  
Sven Haupt ◽  
Matthias Dümpelmann ◽  
...  

2020 ◽  
Vol 31 (2) ◽  
pp. 62-68
Author(s):  
Sara E. Holm ◽  
Alexander Schmidt ◽  
Christoph J. Ploner

Abstract. Some people, although they are perfectly healthy and happy, cannot enjoy music. These individuals have musical anhedonia, a condition which can be congenital or may occur after focal brain damage. To date, only a few cases of acquired musical anhedonia have been reported in the literature with lesions of the temporo-parietal cortex being particularly important. Even less literature exists on congenital musical anhedonia, in which impaired connectivity of temporal brain regions with the Nucleus accumbens is implicated. Nonetheless, there is no precise information on the prevalence, causes or exact localization of both congenital and acquired musical anhedonia. However, the frequent involvement of temporo-parietal brain regions in neurological disorders such as stroke suggest the possibility of a high prevalence of this disorder, which leads to a considerable reduction in the quality of life.


2020 ◽  
Vol 134 (4) ◽  
pp. 309-322 ◽  
Author(s):  
Tristan J. Hynes ◽  
Jacqueline-Marie M. Ferland ◽  
Tanya L. Feng ◽  
Wendy K. Adams ◽  
Mason M. Silveira ◽  
...  

Suchttherapie ◽  
2009 ◽  
Vol 10 (S 01) ◽  
Author(s):  
UJ Müller ◽  
J Voges ◽  
J Heinze ◽  
M Heldmann ◽  
I Galazky ◽  
...  
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