Background:
Recently, there has been a lot of scientific interest in exploring the syntheses of
oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition,
benzisoxazoles play a very important role in organic synthesis as key intermediates.
Objective:
In this paper, we focused on developing a novel synthetic route for biologically active
arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their
anti-inflammatory activities.
Method:
An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles
from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in
MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis.
Result:
We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls,
using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this
reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero
cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2-
acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The
compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the
albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard
drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity.
Conclusion:
A simple, one-pot and convenient method has been explored for the synthesis of novel 3-
methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h
exhibited 51-64% anti-inflammatory activities.
ASYMMETRIC REDUCTION OF PROCHIRAL KETONES WITH A CHIRAL REDUCING AGENT PREPARED FROM STANNOUS CHLORIDE, CHIRAL DIAMINE AS A LIGAND, AND DIISOBUTYLALUMINUM HYDRIDE
