Effect of methanol extract of Moringa oleifera Lam (Moringaceceae) Young Pods on some Serum biochemical parameters in wistar rats

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Biochemical Parameters ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Methanol Extract ◽  
Serum Biochemical Parameters ◽  
Serum Biochemical ◽  
Moringa Oleifera Lam

Long-term cyclosporine treatment: Evaluation of serum biochemical parameters and histopathological alterations in Wistar rats

2011 ◽  
Vol 63 (1-2) ◽  
pp. 119-123 ◽  
Author(s):  
Ana Elisa Böhmer ◽  
André Mendes Ribeiro Corrêa ◽  
Débora Guerini de Souza ◽  
Luisa Knorr ◽  
Gisele Hansel ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Wistar Rats ◽  
Treatment Evaluation ◽  
Serum Biochemical Parameters ◽  
Histopathological Alterations ◽  
Serum Biochemical

Effect of the methanol extract of the red cultivar Allium cepa L. on the serum biochemistry and electrolytes of rats following sub-chronic oral administration

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Adeoye Joshua Oyewusi ◽  
Olayinka A. Oridupa ◽  
Adebowale B. Saba ◽  
Ibironke K. Oyewusi ◽  
Musa F. Mshelbwala
Keyword(s):  
Allium Cepa ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Serum Biochemistry ◽  
Allium Cepa L ◽  
Similar Information ◽  
Group A ◽  
Serum Biochemical ◽  
Group B

AbstractBackgroundIn traditional medicine, Allium cepa Linnaeus is used for the treatment of several disease conditions. Whilst reports abound on the effects of several cultivars of A. cepa L on biochemical parameters, similar information on the red cultivar is scarce. This study examines the effects of the methanol extract of the red cultivar A. cepa L on some serum biochemical parameters in experimental Wistar rats.Materials and methodsFifty-five Wistar rats were divided into three groups (A, B and C), which include 25, 25 and 5 rats, respectively. The rats in Groups A and B were sub-divided into 5 groups of 5 rats. Each rat was administered a certain dose of methanol extract of the red cultivar A. cepa L for 14 days (Group A) or 28 days (Group B). Group C rats served as the control and were administered with distilled water (10 mL/kg).ResultsA. cepa L administration resulted in dyslipidaemia, hyponatremia, hypokalaemia and hyperchloraemia; a significant (p < 0.05) decrease in hepatic enzymes and a significant (p < 0.05) increase in serum bicarbonate, bilirubin and its fractions.ConclusionsThese biochemical results indicate that the excessive and prolonged medicinal consumption of A. cepa L products beyond 7 days may induce moderate hepatic injury and mild renal dysfunction and may complicate disease conditions, such as hypertension and diabetes. Thus, in order to minimize its toxic effects, it is recommended that A. cepa L products should not be used for more than seven consecutive days or beyond a dosage of 90 mg/kg.

scholarly journals Haematology and Serum Biochemical Indices of Lambs Supplemented with Moringa oleifera, Jatropha curcas and Aloe vera Leaf Extract as Anti-Methanogenic Additives

Antibiotics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 601
Author(s):  
Abiodun Mayowa Akanmu ◽  
Abubeker Hassen ◽  
Festus Adeyemi Adejoro
Keyword(s):  
Alkaline Phosphatase ◽  
Plant Extracts ◽  
Biochemical Parameters ◽  
Dry Matter ◽  
Moringa Oleifera ◽  
Aloe Vera ◽  
Control Treatment ◽  
Serum Biochemical Parameters ◽  
Enteric Methane ◽  
Serum Biochemical

Medicinal plants have been found to be effective in a wide range of applications in ruminant animals. However, some plant extracts may be toxic to animals, depending on their seconday metabolite composition and dose, and therefore, animal trials are needed to validate their safety when used as anti-methanogenic additives. This study investigated the effect of three plant extracts used as anti-methanogenic dietary additives, on the haematology and serum biochemical parameters in sheep. Methanolic extracts of Moringa oleifera (MO), Jatropha curcas (JC) and Aloe vera (AV) were orally dosed as experimental treatments for 75 days to sheep, and their effect on the haematology and serum biochemical parameters of SA Mutton Merino (SAMM) lambs were compared with sheep on a control treatment without any additive treatment. Extracts of MO, JC and AV were extracted in 100% methanol, freeze-dried, and reconstituted in distilled water. A total of 40 lambs were ranked according to their body weight into a group of four and one sheep at a time was randomly allocated into four dietary treatments which include a control treatment, and treatment with either MO, JC or AV extract. Lambs were drenched twice daily with doses equivalent to 50 mg/kg dry matter intake (DMI) based on previous week feed consumption. Blood samples were collected via jugular vein puncture and analysed for haematology and serum biochemistry parameters, using standard procedures. The results of the haematological analysis showed that most haematological parameters were not affected by plant extract used as anti-methanogenic additives (p > 0.05), except for higher white blood cell (WBC) and lymphocytes counts recorded in control lambs and lambs in the AV treatment. All serum biochemical properties (except alkaline phosphatase) were not different (p > 0.05) between the control and lambs treated with plant extracts. Alkaline phosphatase was influenced by the plant extract (p < 0.05), with lambs receiving MO, JC and AV having lower alkaline phosphatase concentrations compared to lambs on the control diet without any additive. The result of the study showed that extracts of MO, JC and AV were not toxic to sheep when used as antimethanogenic additives at the recommended dose of 50 mg/kg dry matter feed which had proved previously to be effective in reducing enteric methane emission. Therefore, these plant extracts could be used safely as alternative dietary additives to reduce enteric methane emission and boost the productivity of SA Mutton Merino sheep.

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